RIF1 and DEFB1

Number of citations of the paper that reports this interaction (PMID 15383276)
99

Data Source:
HPRD (two hybrid)

		RIF1	DEFB1
Gene Name		replication timing regulatory factor 1	defensin, beta 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Chromosome, Telomeric Region Female Pronucleus Male Pronucleus Nucleus Cytoplasm Spindle Plasma Membrane	Extracellular Region Extracellular Space Golgi Lumen Extracellular Vesicular Exosome
	Molecular Function
	Biological Process	Cellular Response To DNA Damage Stimulus Cell Cycle Stem Cell Maintenance	Innate Immune Response In Mucosa Acute Inflammatory Response Chemotaxis Immune Response G-protein Coupled Receptor Signaling Pathway Response To Bacterium Antibacterial Humoral Response Response To Testosterone Innate Immune Response Defense Response To Gram-positive Bacterium
Pathways			Beta defensins Defensins Innate Immune System
Drugs
Diseases
GWAS		Lung cancer ( 23143601)
Protein-Protein Interactions		18 interactors: BRD7 CHD3 DEFB1 FEZ1 GIT1 GNE GRB2 HAP1 HMP19 KIAA1377 PABPC4 PIAS4 POT1 PPP1CA PPP1CC SETDB1 SMARCD1 TERF2IP	5 interactors: CCR6 HAP1 MAP4K2 RIF1 VIM
Entrez ID		55183	1672
HPRD ID		10603	03634
Ensembl ID		ENSG00000080345	ENSG00000164825
Uniprot IDs		Q5UIP0	P60022
PDB IDs			1E4S 1IJU 1IJV 1KJ5 2NLB 2NLC 2NLD 2NLE 2NLF 2NLG 2NLH 2NLP 2NLQ 2NLS 2PLZ
Enriched GO Terms of Interacting Partners?		Telomere Maintenance Via Telomere Lengthening Telomere Capping Telomere Maintenance Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Cell Cycle Cellular Response To Growth Factor Stimulus Response To Growth Factor Chromosome Organization Cellular Macromolecule Biosynthetic Process Regulation Of Telomere Maintenance Macromolecule Biosynthetic Process Triglyceride Catabolic Process Regulation Of Response To DNA Damage Stimulus RNA-dependent DNA Replication Entrainment Of Circadian Clock By Photoperiod Cell Surface Receptor Signaling Pathway Photoperiodism Entrainment Of Circadian Clock Acylglycerol Catabolic Process Positive Regulation Of Organelle Organization Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Metabolic Process Regulation Of Organelle Organization Regulation Of Chromosome Organization Negative Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Carbohydrate Metabolic Process Positive Regulation Of Neurotrophin Production Positive Regulation Of Nonmotile Primary Cilium Assembly Positive Regulation Of DNA Strand Elongation Negative Regulation Of DNA Recombination At Telomere Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Transcription, DNA-templated Chemotaxis Biosynthetic Process Glycogen Metabolic Process Regulation Of Gene Expression Regulation Of DNA Repair Organelle Organization DNA Replication RNA Biosynthetic Process Positive Regulation Of Response To DNA Damage Stimulus RNA Metabolic Process Cell Projection Organization Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Response To External Stimulus	Movement Of Cell Or Subcellular Component Positive Regulation Of Neurotrophin Production Positive Regulation Of Nonmotile Primary Cilium Assembly Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Cilium Assembly Establishment Of Vesicle Localization Vesicle Localization Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Bergmann Glial Cell Differentiation Cellular Response To Stimulus Establishment Of Organelle Localization Hypothalamus Cell Differentiation Response To Stress Negative Regulation Of Beta-amyloid Formation Retrograde Axon Cargo Transport Cellular Response To Stress Regulation Of Cell Differentiation Dendritic Cell Chemotaxis Negative Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Microtubule-based Movement Organelle Localization Positive Regulation Of Synaptic Transmission, GABAergic Nucleotide-excision Repair, DNA Gap Filling Negative Regulation Of Smooth Muscle Cell Migration DNA Demethylation Intermediate Filament Organization Regulation Of Cell Projection Organization Lens Fiber Cell Development Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Telomere Maintenance Via Semi-conservative Replication Regulation Of Beta-amyloid Formation Astrocyte Development Regulation Of Cilium Assembly Nuclear DNA Replication Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Amyloid Precursor Protein Catabolic Process Telomere Maintenance Via Recombination Response To Stimulus Positive Regulation Of ERBB Signaling Pathway Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Dendritic Cell Migration Hypothalamus Development Positive Regulation Of Organelle Assembly Positive Regulation Of Cell Cycle G1/S Phase Transition Anterograde Axon Cargo Transport Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening
Tagcloud ?		53bp1 artemis brca1 collectively competes decided deficient doubly downstream effector effectors enzymatic homolog homologous interacting joining nonhomologous nuclease parp parpi parpis prevents ptip rap1 recombination repair resection restores uncovered	20g 44c 52g 5g 87a analysed antimicrobial brazilian constitutively corrections defence defensin gcaaa genital haplotype hbd hpv innate member microorganisms mucosa namely nucleotide papillomavirus polymorphisms snp snps utr viruses
Tagcloud (Difference) ?		53bp1 artemis brca1 collectively competes decided deficient doubly downstream effector effectors enzymatic homolog homologous interacting joining nonhomologous nuclease parp parpi parpis prevents ptip rap1 recombination repair resection restores uncovered	20g 44c 52g 5g 87a analysed antimicrobial brazilian constitutively corrections defence defensin gcaaa genital haplotype hbd hpv innate member microorganisms mucosa namely nucleotide papillomavirus polymorphisms snp snps utr viruses
Tagcloud (Intersection) ?