RIF1 and SETDB1

Number of citations of the paper that reports this interaction (PubMedID 15383276)
0

Data Source:
HPRD (two hybrid)

		RIF1	SETDB1
Description		replication timing regulatory factor 1	SET domain bifurcated histone lysine methyltransferase 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Condensed Chromosome Female Pronucleus Male Pronucleus Nucleus Nucleoplasm Chromosome Cytoplasm Spindle Cytoskeleton Plasma Membrane Nuclear Membrane Site Of Double-strand Break Spindle Midzone Chromosome, Telomeric Repeat Region	Nucleus Nucleoplasm Chromosome Cytoplasm
	Molecular Function	Protein Binding	DNA Binding Chromatin Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Histone Methyltransferase Activity Metal Ion Binding Histone H3K9 Methyltransferase Activity Histone H3 Methyltransferase Activity Histone H3K9me2 Methyltransferase Activity Histone H3K9 Monomethyltransferase Activity Histone H3K9 Trimethyltransferase Activity Promoter-specific Chromatin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Telomere Maintenance DNA Repair DNA Damage Response Subtelomeric Heterochromatin Formation Somatic Stem Cell Population Maintenance Telomere Maintenance In Response To DNA Damage Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Isotype Switching Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Chromatin Organization DNA Methylation-dependent Constitutive Heterochromatin Formation Negative Regulation Of Gene Expression Methylation Heterochromatin Organization Transposable Element Silencing By Heterochromatin Formation
Pathways		Nonhomologous End-Joining (NHEJ)	PKMTs methylate histone lysines Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Drugs
Diseases
GWAS		Lung cancer ( 23143601) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483)	Body mass index ( 26426971) Caffeine consumption from coffee or tea ( 33287642) Caffeine consumption from tea ( 33287642) Chronic kidney disease ( 20383146) Coffee consumption ( 31046077) Cutaneous squamous cell carcinoma ( 32041948) Hip circumference adjusted for BMI ( 34021172) Melanoma ( 21983785) Neurological blood protein biomarker levels ( 31320639) Nevus count or cutaneous melanoma ( 30429480)
Interacting Genes		20 interacting genes: BRD7 CEP126 CHD3 DEFB1 FEZ1 GIT1 GNE GRB2 HAP1 LINC00839 NSG2 PABPC4 PIAS4 POT1 PPP1CC SETDB1 SMARCD1 SUMO2 TERF2IP UBC	110 interacting genes: AIFM1 AKT1 ANXA7 APC APLP1 ASAH1 ATF7IP ATF7IP2 BAG6 BARD1 BHLHE40 BID BRIX1 BTBD2 BTG3 CBX8 CCDC106 CDK4 CDKN1A CFAP68 CLSTN1 CREBBP CRELD1 DAP DLEU1 DNMT3A ECSIT ERG ERH FAM118B FLYWCH1 GIPC2 GPS2 GRB7 GSTO1 H3-4 H3C1 H3C15 H4C16 HDAC1 HDAC2 HMOX2 HSPB3 JARID2 KDM1A LRIF1 LUC7L2 MAD2L1BP MAP4K5 MBD1 MDM2 MOB4 MRPL44 MZT2B NIPSNAP3A OLFML3 ORAI2 PABPC4 PAFAH1B3 PCDHA4 PCYT2 PGAM5 PHF10 PIAS4 PLEKHA4 POLA2 PPA1 PPP1R8 PRKRA PSMD11 PSME1 PTPRS QTRT1 RIF1 RNF10 S100A10 SAT1 SERPINB9 SIN3A SIN3B SKIL SLC38A3 SMN1 SNIP1 SUFU SULT1E1 SUMO2 TARDBP TCERG1 THAP8 TK1 TOB1 TOLLIP TPI1 TRBV2 TRDMT1 TRIB3 TRIM16 TRIM28 TRIP6 TSC22D1 TTR TXNDC9 UBE2I ULK2 USP11 VHL VIM ZFP64 ZNF24
Entrez ID		55183	9869
HPRD ID		10603	06828
Ensembl ID		ENSG00000080345	ENSG00000143379
Uniprot IDs		Q5UIP0	A0A8I5KT93 Q15047 X6R732
PDB IDs			3DLM 4X3S 5KCH 5KCO 5KE2 5KE3 5KH6 5QT1 5QT2 6AU2 6AU3 6BHD 6BHE 6BHG 6BHH 6BHI 6BPI 7C9N 7CAJ 7CD9 7CJT 8G5E 8IYA 8UWP 9CUW 9CUX
Enriched GO Terms of Interacting Partners?		Regulation Of Double-strand Break Repair Regulation Of DNA Repair Positive Regulation Of DNA Metabolic Process Shelterin Complex Regulation Of Microtubule-based Movement Regulation Of Organelle Organization Regulation Of Organelle Transport Along Microtubule Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding Centrosome Telomere Capping Presynapse RSC-type Complex Protein Tag Activity Protein Phosphatase Binding Regulation Of Chromosome Organization Regulation Of Microtubule-based Process Positive Regulation Of Double-strand Break Repair Regulation Of DNA Metabolic Process Positive Regulation Of Organelle Organization SUMO Transferase Activity PML Body Regulation Of Cellular Response To Stress Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Regulation Of Nucleotide-excision Repair Positive Regulation Of DNA Repair Nuclear Matrix Growth Cone Negative Regulation Of DNA Metabolic Process Telomere Maintenance Via Telomere Lengthening Telomeric DNA Binding Gamma-tubulin Binding Guanyl-nucleotide Exchange Factor Adaptor Activity Chromosome Chromosome, Telomeric Region Kinetochore Regulation Of G0 To G1 Transition Positive Regulation Of Neurotrophin Production Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion N-acetylglucosamine Biosynthetic Process UDP-N-acetylglucosamine 2-epimerase Activity Negative Regulation Of Telomere Maintenance Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Negative Regulation Of ARF Protein Signal Transduction Positive Regulation Of Myoblast Differentiation Regulation Of Metabolic Process Positive Regulation Of Cellular Component Organization	Transcription Corepressor Activity Nucleus Nucleoplasm Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Heterochromatin Formation Negative Regulation Of Gene Expression, Epigenetic SUMO Transferase Activity Regulation Of RNA Metabolic Process Chromatin Remodeling Epigenetic Regulation Of Gene Expression Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Cellular Response To Stress Chromatin Organization Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Transcription Coregulator Activity Constitutive Heterochromatin Formation Cytoplasm MRF Binding Chromatin Binding Transcription Regulator Complex DNA Methylation-dependent Constitutive Heterochromatin Formation Ubiquitin Protein Ligase Binding Sin3-type Complex Regulation Of Mitotic Cell Cycle Phase Transition Heterochromatin Protein Sumoylation Nuclear Matrix Nuclear Body RNA Binding Regulation Of Intrinsic Apoptotic Signaling Pathway RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Proteolysis Krueppel-associated Box Domain Binding Enzyme Binding
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