RIF1 and SETDB1

Number of citations of the paper that reports this interaction (PMID 15383276)
99

Data Source:
HPRD (two hybrid)

		RIF1	SETDB1
Gene Name		replication timing regulatory factor 1	SET domain, bifurcated 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Chromosome, Telomeric Region Female Pronucleus Male Pronucleus Nucleus Cytoplasm Spindle Plasma Membrane	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Plasma Membrane Intracellular Membrane-bounded Organelle
	Molecular Function		DNA Binding Protein Binding Zinc Ion Binding Histone-lysine N-methyltransferase Activity
	Biological Process	Cellular Response To DNA Damage Stimulus Cell Cycle Stem Cell Maintenance	Negative Regulation Of Transcription From RNA Polymerase II Promoter Inner Cell Mass Cell Proliferation Chromatin Organization Transcription, DNA-templated Histone H3-K9 Trimethylation Bone Development
Pathways			Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines
Drugs
Diseases
GWAS		Lung cancer ( 23143601)	Chronic kidney disease ( 20383146) Melanoma ( 21983785)
Protein-Protein Interactions		18 interactors: BRD7 CHD3 DEFB1 FEZ1 GIT1 GNE GRB2 HAP1 HMP19 KIAA1377 PABPC4 PIAS4 POT1 PPP1CA PPP1CC SETDB1 SMARCD1 TERF2IP	107 interactors: AIFM1 AKT1 ANXA7 APC APLP1 ASAH1 ATF7IP ATF7IP2 BAG6 BARD1 BHLHE40 BID BRIX1 BTBD2 C11orf1 CBX8 CCDC106 CDK4 CDKN1A CLSTN1 CRELD1 DAP DLEU1 DNMT3A ECSIT ERG ERH FAM118B FLYWCH1 GIPC2 GPS2 GRB7 GSTO1 HDAC1 HDAC2 HIST1H3A HIST2H3A HIST3H3 HIST4H4 HMOX2 HSPB3 JARID2 KDM1A LRIF1 LUC7L2 MAD2L1BP MAP4K5 MBD1 MDM2 MOB4 MRPL44 MZT2B NIPSNAP3A OLFML3 ORAI2 PABPC4 PAFAH1B3 PCDHA4 PCYT2 PGAM5 PHF10 PIAS4 PLEKHA4 POLA2 PPA1 PPARG PPP1R8 PRKRA PSMD11 PSME1 PTPRS QTRT1 RIF1 RNF10 S100A10 SAT1 SERPINB9 SIN3A SIN3B SKIL SLC38A3 SMN1 SNIP1 SUFU SULT1E1 SUMO2 TARDBP TCERG1 THAP8 TK1 TOB1 TOLLIP TPI1 TRBV2 TRDMT1 TRIB3 TRIM16 TRIM28 TSC22D1 TTR TXNDC9 UBE2I ULK2 USP11 VIM ZFP64 ZNF24
Entrez ID		55183	9869
HPRD ID		10603	06828
Ensembl ID		ENSG00000080345	ENSG00000143379
Uniprot IDs		Q5UIP0	Q15047
PDB IDs			3DLM
Enriched GO Terms of Interacting Partners?		Telomere Maintenance Via Telomere Lengthening Telomere Capping Telomere Maintenance Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Cell Cycle Cellular Response To Growth Factor Stimulus Response To Growth Factor Chromosome Organization Cellular Macromolecule Biosynthetic Process Regulation Of Telomere Maintenance Macromolecule Biosynthetic Process Triglyceride Catabolic Process Regulation Of Response To DNA Damage Stimulus RNA-dependent DNA Replication Entrainment Of Circadian Clock By Photoperiod Cell Surface Receptor Signaling Pathway Photoperiodism Entrainment Of Circadian Clock Acylglycerol Catabolic Process Positive Regulation Of Organelle Organization Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Metabolic Process Regulation Of Organelle Organization Regulation Of Chromosome Organization Negative Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Carbohydrate Metabolic Process Positive Regulation Of Neurotrophin Production Positive Regulation Of Nonmotile Primary Cilium Assembly Positive Regulation Of DNA Strand Elongation Negative Regulation Of DNA Recombination At Telomere Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Transcription, DNA-templated Chemotaxis Biosynthetic Process Glycogen Metabolic Process Regulation Of Gene Expression Regulation Of DNA Repair Organelle Organization DNA Replication RNA Biosynthetic Process Positive Regulation Of Response To DNA Damage Stimulus RNA Metabolic Process Cell Projection Organization Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Response To External Stimulus	Negative Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Cellular Metabolic Process Regulation Of Gene Expression, Epigenetic Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Negative Regulation Of Gene Expression, Epigenetic DNA Methylation On Cytosine Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process DNA Methylation Regulation Of Apoptotic Process Regulation Of RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Chromosome Organization Regulation Of RNA Biosynthetic Process Regulation Of Cell Death Regulation Of Transcription, DNA-templated Regulation Of Proteolysis DNA Modification Cellular Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Protein Metabolic Process Chromatin Organization Positive Regulation Of Metabolic Process Response To Stress Transcription, DNA-templated Gene Silencing Positive Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis Chromatin Silencing Metabolic Process RNA Biosynthetic Process Negative Regulation Of Protein Metabolic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Negative Regulation Of Cell Cycle
Tagcloud ?		53bp1 artemis brca1 collectively competes decided deficient doubly downstream effector effectors enzymatic homolog homologous interacting joining nonhomologous nuclease parp parpi parpis prevents ptip rap1 recombination repair resection restores uncovered	adversely astrocytic astroglial chaetocin clarified clinicopathological clonogenic correlating deregulation emerges glioblastomas gliomagenesis grades h1x h3k9 h3k9me3 h4k20me3 immunoblotting implicates inversely linker methyltransferases migratory pathobiology prognosticator reportedly suv39h1 t98g verified
Tagcloud (Difference) ?		53bp1 artemis brca1 collectively competes decided deficient doubly downstream effector effectors enzymatic homolog homologous interacting joining nonhomologous nuclease parp parpi parpis prevents ptip rap1 recombination repair resection restores uncovered	adversely astrocytic astroglial chaetocin clarified clinicopathological clonogenic correlating deregulation emerges glioblastomas gliomagenesis grades h1x h3k9 h3k9me3 h4k20me3 immunoblotting implicates inversely linker methyltransferases migratory pathobiology prognosticator reportedly suv39h1 t98g verified
Tagcloud (Intersection) ?