RIF1 and PPP1CC

Number of citations of the paper that reports this interaction (PMID 21382349)
13

Data Source:
BioGRID (two hybrid, two hybrid)

		RIF1	PPP1CC
Gene Name		replication timing regulatory factor 1	protein phosphatase 1, catalytic subunit, gamma isozyme
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Chromosome, Telomeric Region Female Pronucleus Male Pronucleus Nucleus Cytoplasm Spindle Plasma Membrane	Condensed Chromosome Kinetochore Nucleus Nucleolus Cytoplasm Mitochondrion Cytosol Focal Adhesion Nuclear Speck Midbody Cleavage Furrow Protein Complex MLL5-L Complex PTW/PP1 Phosphatase Complex
	Molecular Function		Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Phosphatase Activity Protein Kinase Binding Poly(A) RNA Binding Metal Ion Binding
	Biological Process	Cellular Response To DNA Damage Stimulus Cell Cycle Stem Cell Maintenance	Mitotic Cell Cycle Glycogen Metabolic Process Protein Dephosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Triglyceride Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Small Molecule Metabolic Process Cell Division
Pathways			Loss of Function of TGFBR2 in Cancer Mitotic Prometaphase Metabolism of lipids and lipoproteins Separation of Sister Chromatids Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer TGF-beta receptor signaling activates SMADs Mitotic Anaphase TGFBR1 LBD Mutants in Cancer M Phase Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Lipid digestion, mobilization, and transport Cell Cycle, Mitotic Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex Resolution of Sister Chromatid Cohesion Mitotic Metaphase and Anaphase SMAD4 MH2 Domain Mutants in Cancer
Drugs			9,10-Deepithio-9,10-Didehydroacanthifolicin Calyculin A (2S,5R,8S,11R,12S,15S,18S,19S,E)-8-ISOBUTYL-18-((5S,6S)-6-METHOXY-3,5-DIMETHYL-7-PHENYLHEPTYL)-1,2,5,12,15,19-HEXAMETHYL-3,6,9,13,16,20,25-HEPTAOXO-1,4,7,10,14,17,21-HEPTAAZACYCLOPENTACOS-21-ENE-11,22-DICARBOXYLIC ACID Motuporin
Diseases
GWAS		Lung cancer ( 23143601)	Heart rate ( 23583979)
Protein-Protein Interactions		18 interactors: BRD7 CHD3 DEFB1 FEZ1 GIT1 GNE GRB2 HAP1 HMP19 KIAA1377 PABPC4 PIAS4 POT1 PPP1CA PPP1CC SETDB1 SMARCD1 TERF2IP	114 interactors: AATK ABT1 ACAD8 AKAP11 ANKRD42 APIP APP ASH2L AURKA B4GAT1 BMPR2 BTBD10 C11orf74 C15orf59 C1QA C9orf50 CD2BP2 CLMN CLTC CNST COPS5 CSNK1A1 CSRNP1 CSRNP2 CTSL CYFIP1 DACT1 DEAF1 DYRK4 EIF2AK2 ELP4 ENKD1 FTL FXYD6 GLB1L GOLGA7 GSTZ1 HCFC1 HDAC6 HMGN1 IL3RA JAK2 KCTD20 KDM4D KIAA1377 KRCC1 LMTK2 MAP4K4 MYO16 NAPEPLD NEK2 NMT2 NONO NRBP1 NUAK1 PHACTR4 PHC1 PIAS1 PPP1R13B PPP1R15B PPP1R16A PPP1R18 PPP1R2 PPP1R32 PPP1R35 PPP1R3C PPP1R3D PPP1R8 PPP1R9B PRR16 RAF1 RB1 RIF1 RNF19B RPL7 RPRD2 RRM1 RRP1B SDR39U1 SGCE SH3RF2 SHANK3 SMARCB1 SMG6 SPATC1L SPOCD1 STAM STARD9 STAU1 TACC2 TBC1D19 TCTEX1D4 TEFM TEX36 TLX1 TLX3 TMEM120A TNS1 TOPBP1 TOR1AIP1 TP53 TP53BP2 TPRN TRA2A TWISTNB VSTM4 WBP11 YLPM1 YWHAZ ZDBF2 ZFYVE9 ZNF24 ZNF318 ZNF667
Entrez ID		55183	5501
HPRD ID		10603	08911
Ensembl ID		ENSG00000080345	ENSG00000186298
Uniprot IDs		Q5UIP0	P36873
PDB IDs			1IT6 1JK7 1U32 2BCD 2BDX
Enriched GO Terms of Interacting Partners?		Telomere Maintenance Via Telomere Lengthening Telomere Capping Telomere Maintenance Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Cell Cycle Cellular Response To Growth Factor Stimulus Response To Growth Factor Chromosome Organization Cellular Macromolecule Biosynthetic Process Regulation Of Telomere Maintenance Macromolecule Biosynthetic Process Triglyceride Catabolic Process Regulation Of Response To DNA Damage Stimulus RNA-dependent DNA Replication Entrainment Of Circadian Clock By Photoperiod Cell Surface Receptor Signaling Pathway Photoperiodism Entrainment Of Circadian Clock Acylglycerol Catabolic Process Positive Regulation Of Organelle Organization Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Metabolic Process Regulation Of Organelle Organization Regulation Of Chromosome Organization Negative Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Carbohydrate Metabolic Process Positive Regulation Of Neurotrophin Production Positive Regulation Of Nonmotile Primary Cilium Assembly Positive Regulation Of DNA Strand Elongation Negative Regulation Of DNA Recombination At Telomere Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Transcription, DNA-templated Chemotaxis Biosynthetic Process Glycogen Metabolic Process Regulation Of Gene Expression Regulation Of DNA Repair Organelle Organization DNA Replication RNA Biosynthetic Process Positive Regulation Of Response To DNA Damage Stimulus RNA Metabolic Process Cell Projection Organization Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Response To External Stimulus	Regulation Of Dephosphorylation Regulation Of Phosphatase Activity Regulation Of Phosphorus Metabolic Process Gene Expression Negative Regulation Of Phosphatase Activity RNA Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Dephosphorylation RNA Biosynthetic Process Transcription, DNA-templated Negative Regulation Of Catalytic Activity Cellular Macromolecule Biosynthetic Process Cellular Metabolic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Process Cellular Aromatic Compound Metabolic Process Nervous System Development Regulation Of Catalytic Activity Heterocycle Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Hydrolase Activity Nitrogen Compound Metabolic Process Peptidyl-amino Acid Modification Chromatin Organization Neurogenesis Regulation Of Signal Transduction Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Generation Of Neurons Chromosome Organization Regulation Of Gene Expression Neuron Apoptotic Process Cellular Localization Response To Radiation Regulation Of Signaling Regulation Of Cell Cycle Regulation Of Cellular Component Organization Negative Regulation Of Cellular Metabolic Process Cell Cycle Neuron Death Apoptotic Process Chromatin Modification Spindle Organization Cellular Protein Modification Process Histone Modification Neuron Differentiation Cellular Component Assembly Programmed Cell Death Transcription From RNA Polymerase II Promoter
Tagcloud ?		53bp1 artemis brca1 collectively competes decided deficient doubly downstream effector effectors enzymatic homolog homologous interacting joining nonhomologous nuclease parp parpi parpis prevents ptip rap1 recombination repair resection restores uncovered	3xflag atp5c1 compatible created creating ddost deleted dissociated envelope immunolocalization knock mammals persists phosphatases reciprocal sbp sedimentation spermatogenesis spermatogenic splice tagged tandem testis ubiquitously
Tagcloud (Difference) ?		53bp1 artemis brca1 collectively competes decided deficient doubly downstream effector effectors enzymatic homolog homologous interacting joining nonhomologous nuclease parp parpi parpis prevents ptip rap1 recombination repair resection restores uncovered	3xflag atp5c1 compatible created creating ddost deleted dissociated envelope immunolocalization knock mammals persists phosphatases reciprocal sbp sedimentation spermatogenesis spermatogenic splice tagged tandem testis ubiquitously
Tagcloud (Intersection) ?