RIF1 and BRD7

Number of citations of the paper that reports this interaction (PMID 15383276)
99

Data Source:
HPRD (two hybrid)

		RIF1	BRD7
Gene Name		replication timing regulatory factor 1	bromodomain containing 7
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Chromosome, Telomeric Region Female Pronucleus Male Pronucleus Nucleus Cytoplasm Spindle Plasma Membrane	Nucleus Cytoplasm
	Molecular Function		P53 Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Histone Binding Transcription Regulatory Region DNA Binding Lysine-acetylated Histone Binding
	Biological Process	Cellular Response To DNA Damage Stimulus Cell Cycle Stem Cell Maintenance	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Cell Cycle Negative Regulation Of Cell Proliferation Wnt Signaling Pathway Positive Regulation Of Histone Acetylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
Drugs
Diseases
GWAS		Lung cancer ( 23143601)
Protein-Protein Interactions		18 interactors: BRD7 CHD3 DEFB1 FEZ1 GIT1 GNE GRB2 HAP1 HMP19 KIAA1377 PABPC4 PIAS4 POT1 PPP1CA PPP1CC SETDB1 SMARCD1 TERF2IP	27 interactors: AGR2 BARD1 BHLHE40 BRD3 BTBD2 DVL1 FTH1 HAP1 HIST1H2AL HIST2H2BE HIST2H3C HIST3H3 HIST4H4 HNRNPUL1 IRF2 LAMA4 LRIF1 NEFL PAFAH1B3 PCBD1 PSMD11 PTPN13 RBFOX2 RIF1 RPLP1 SERPINB9 TRIM24
Entrez ID		55183	29117
HPRD ID		10603	12531
Ensembl ID		ENSG00000080345	ENSG00000166164
Uniprot IDs		Q5UIP0	Q9NPI1
PDB IDs			2I7K
Enriched GO Terms of Interacting Partners?		Telomere Maintenance Via Telomere Lengthening Telomere Capping Telomere Maintenance Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Cell Cycle Cellular Response To Growth Factor Stimulus Response To Growth Factor Chromosome Organization Cellular Macromolecule Biosynthetic Process Regulation Of Telomere Maintenance Macromolecule Biosynthetic Process Triglyceride Catabolic Process Regulation Of Response To DNA Damage Stimulus RNA-dependent DNA Replication Entrainment Of Circadian Clock By Photoperiod Cell Surface Receptor Signaling Pathway Photoperiodism Entrainment Of Circadian Clock Acylglycerol Catabolic Process Positive Regulation Of Organelle Organization Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Metabolic Process Regulation Of Organelle Organization Regulation Of Chromosome Organization Negative Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Carbohydrate Metabolic Process Positive Regulation Of Neurotrophin Production Positive Regulation Of Nonmotile Primary Cilium Assembly Positive Regulation Of DNA Strand Elongation Negative Regulation Of DNA Recombination At Telomere Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Transcription, DNA-templated Chemotaxis Biosynthetic Process Glycogen Metabolic Process Regulation Of Gene Expression Regulation Of DNA Repair Organelle Organization DNA Replication RNA Biosynthetic Process Positive Regulation Of Response To DNA Damage Stimulus RNA Metabolic Process Cell Projection Organization Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Response To External Stimulus	Gene Expression Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Regulation Of RNA Metabolic Process Retrograde Axon Cargo Transport Transcription, DNA-templated Telomere Maintenance DNA Methylation On Cytosine DNA Modification Chromatin Silencing At RDNA Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Neuromuscular Process Negative Regulation Of Biosynthetic Process Anterograde Axon Cargo Transport Cellular Response To Estrogen Stimulus Chromatin Silencing Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Neurotrophin Production Positive Regulation Of Nonmotile Primary Cilium Assembly Regulation Of Metabolic Process Axon Cargo Transport Regulation Of Gene Expression, Epigenetic Positive Regulation Of Protein Catabolic Process DNA Methylation Demethylation Mucus Secretion Intracellular Sequestering Of Iron Ion Negative Regulation Of MRNA 3'-end Processing Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Homeostatic Process Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Cell Projection Organization Neuromuscular Process Controlling Balance Convergent Extension Involved In Neural Plate Elongation
Tagcloud ?		53bp1 artemis brca1 collectively competes decided deficient doubly downstream effector effectors enzymatic homolog homologous interacting joining nonhomologous nuclease parp parpi parpis prevents ptip rap1 recombination repair resection restores uncovered	aza clinically cofactor dc demethylating disturbing ectopic endogenous finding glioma gliomas hypermethylation implicated inactivated inactivation intracranial lrrc4 magnetic microrna mir negatively pathological researches resonance restoration silencing transcriptional transplanted verified
Tagcloud (Difference) ?		53bp1 artemis brca1 collectively competes decided deficient doubly downstream effector effectors enzymatic homolog homologous interacting joining nonhomologous nuclease parp parpi parpis prevents ptip rap1 recombination repair resection restores uncovered	aza clinically cofactor dc demethylating disturbing ectopic endogenous finding glioma gliomas hypermethylation implicated inactivated inactivation intracranial lrrc4 magnetic microrna mir negatively pathological researches resonance restoration silencing transcriptional transplanted verified
Tagcloud (Intersection) ?