DNALI1 and GJB5

		DNALI1	GJB5
Description		dynein axonemal light intermediate chain 1	gap junction protein beta 5
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cilium Axoneme Microtubule Cytoskeleton Filopodium Dynein Complex Motile Cilium Sperm Flagellum Cell Projection Intercellular Bridge Mitotic Spindle Ciliary Base 9+2 Motile Cilium Dynein Axonemal Particle	Plasma Membrane Gap Junction Connexin Complex Membrane Anchoring Junction
	Molecular Function	Protein Binding Dynein Heavy Chain Binding	Gap Junction Channel Activity Protein Binding
	Biological Process	Sperm Flagellum Assembly	Cell Communication Cell-cell Signaling Epidermis Development Transmembrane Transport Trophoblast Giant Cell Differentiation Labyrinthine Layer Morphogenesis
Pathways			Gap junction assembly
Drugs
Diseases
GWAS		Axial length ( 24144296) Eyebrow thickness ( 26926045) Intraocular pressure ( 29617998)	BMI x environmental factors (excluding physical activity) interaction ( 33654129) BMI x environmental factors (including physical activity) interaction ( 33654129) Narcolepsy ( 23459209) Sleep duration (short sleep) ( 30846698) Triglyceride levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Visceral adipose tissue adjusted for BMI ( 22589738)
Interacting Genes		7 interacting genes: ABCF3 APP EPS8 HTT MSGN1 PRMT6 SIAH1	44 interacting genes: APOL2 APOL3 AQP1 ARLN C1GALT1 COMT CTXN3 CYB5B ERG28 FAM3C GSK3B IGFBP5 JAGN1 LMNA LPAR3 LRP10 MED1 MIP MS4A13 MYL2 NAPB PCGF2 PGAP2 PLPP4 PLPP6 PNLIPRP1 RPRM RTP2 SEC22A SEC22B SERP1 SLC30A2 SLC38A7 SLC41A1 SLC41A2 SMIM1 TM4SF4 TMEM128 TMEM60 TMEM86A TMEM97 TRIM2 TSPO2 VSTM1
Entrez ID		7802	2709
HPRD ID		03681	06840
Ensembl ID		ENSG00000163879	ENSG00000189280
Uniprot IDs		A0A499FIY3 O14645	A0A654IE64 O95377
PDB IDs		8J07
Enriched GO Terms of Interacting Partners?		Gap Junction Channel Activity Connexin Complex Amyloid Fibril Formation Gap Junction Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Positive Regulation Of Calcium-mediated Signaling Amylin Binding Positive Regulation Of Toll Signaling Pathway Protein Destabilization Histone H2AR3 Methyltransferase Activity Acetylcholine Receptor Activator Activity PTB Domain Binding Adult Locomotory Behavior Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Early Endosome Growth Cone Filopodium Regulation Of Calcium-mediated Signaling Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Labyrinthine Layer Morphogenesis Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of CAMKK-AMPK Signaling Cascade Histone H3R2 Methyltransferase Activity Histone Arginine N-methyltransferase Activity Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Cone Growth Factor Receptor Binding Main Axon Chromatin Binding Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Supramolecular Fiber Organization Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Regulation Of CAMKK-AMPK Signaling Cascade Positive Regulation Of Aggrephagy	Membrane Monoatomic Cation Transmembrane Transporter Activity Endoplasmic Reticulum Membrane Protein Binding Neutrophil Differentiation Inorganic Cation Transmembrane Transporter Activity
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