DNALI1 and GJA4

		DNALI1	GJA4
Description		dynein axonemal light intermediate chain 1	gap junction protein alpha 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cilium Axoneme Microtubule Cytoskeleton Filopodium Dynein Complex Motile Cilium Sperm Flagellum Cell Projection Intercellular Bridge Mitotic Spindle Ciliary Base 9+2 Motile Cilium Dynein Axonemal Particle	Plasma Membrane Gap Junction Connexin Complex Membrane Anchoring Junction
	Molecular Function	Protein Binding Dynein Heavy Chain Binding	Gap Junction Channel Activity Protein Binding
	Biological Process	Sperm Flagellum Assembly	Blood Vessel Development Cell-cell Junction Assembly Cell Communication Cell-cell Signaling Transmembrane Transport
Pathways			Gap junction assembly
Drugs
Diseases
GWAS		Axial length ( 24144296) Eyebrow thickness ( 26926045) Intraocular pressure ( 29617998)	Formal thought disorder in schizophrenia ( 22648509) Triglyceride levels x thiazide or thiazide-like diuretics use interaction ( 31806883)
Interacting Genes		7 interacting genes: ABCF3 APP EPS8 HTT MSGN1 PRMT6 SIAH1	5 interacting genes: CD81 MS4A13 OPRM1 SLC29A2 TMEM86B
Entrez ID		7802	2701
HPRD ID		03681	08509
Ensembl ID		ENSG00000163879	ENSG00000187513
Uniprot IDs		A0A499FIY3 O14645	P35212
PDB IDs		8J07
Enriched GO Terms of Interacting Partners?		Gap Junction Channel Activity Connexin Complex Amyloid Fibril Formation Gap Junction Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Positive Regulation Of Calcium-mediated Signaling Amylin Binding Positive Regulation Of Toll Signaling Pathway Protein Destabilization Histone H2AR3 Methyltransferase Activity Acetylcholine Receptor Activator Activity PTB Domain Binding Adult Locomotory Behavior Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Early Endosome Growth Cone Filopodium Regulation Of Calcium-mediated Signaling Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Labyrinthine Layer Morphogenesis Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of CAMKK-AMPK Signaling Cascade Histone H3R2 Methyltransferase Activity Histone Arginine N-methyltransferase Activity Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Cone Growth Factor Receptor Binding Main Axon Chromatin Binding Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Supramolecular Fiber Organization Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Regulation Of CAMKK-AMPK Signaling Cascade Positive Regulation Of Aggrephagy	Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Macrophage Fusion Positive Regulation Of Adaptive Immune Memory Response CD4-positive, Alpha-beta T Cell Costimulation Myoblast Fusion Involved In Skeletal Muscle Regeneration Cytidine Transmembrane Transporter Activity Uracil Transmembrane Transport Thymine Transport Inosine Transport Pyrimidine Nucleobase Transmembrane Transport Nucleobase Transmembrane Transporter Activity Cytidine Transport Uracil Transmembrane Transporter Activity Purine Nucleoside Transmembrane Transport Guanine Transmembrane Transporter Activity Guanine Transport Guanine Transmembrane Transport Adenosine Transport Hypoxanthine Transport Purine Nucleoside Transmembrane Transporter Activity Regulation Of NMDA Receptor Activity Cellular Response To Morphine Morphine Receptor Activity Negative Regulation Of Wnt Protein Secretion Beta-endorphin Receptor Activity D-lysine 5,6-aminomutase Activity Ether Hydrolase Activity Alkenylglycerophosphocholine Hydrolase Activity Humoral Immune Response Mediated By Circulating Immunoglobulin Uridine Transmembrane Transport Adenine Transmembrane Transporter Activity Pyrimidine Nucleoside Transport Nucleoside Transmembrane Transporter Activity Uridine Transmembrane Transporter Activity MHC Class II Protein Binding Osteoclast Fusion Nucleoside Transmembrane Transport Adenine Transport Nucleoside Transport Pyrimidine Nucleobase Transport Positive Regulation Of Protein Catabolic Process In The Vacuole Purine Nucleobase Transmembrane Transport G Protein-coupled Opioid Receptor Activity Positive Regulation Of B Cell Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Basolateral Plasma Membrane Positive Regulation Of T-helper 2 Cell Cytokine Production Tetraspanin-enriched Microdomain G Protein-coupled Opioid Receptor Signaling Pathway Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation
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