CHTF8 and WBP4

Number of citations of the paper that reports this interaction (PubMedID 16055720)
76

Data Source:
BioGRID (pull down)

		CHTF8	WBP4
Description		chromosome transmission fidelity factor 8	WW domain binding protein 4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Ctf18 RFC-like Complex	Nucleus Nucleoplasm Spliceosomal Complex Nuclear Speck U2-type Precatalytic Spliceosome Precatalytic Spliceosome
	Molecular Function	DNA Binding DNA Clamp Loader Activity Protein Binding Single-stranded DNA Helicase Activity	Nucleic Acid Binding RNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Proline-rich Region Binding
	Biological Process	DNA Replication Mitotic Sister Chromatid Cohesion Positive Regulation Of DNA-directed DNA Polymerase Activity	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing MRNA Cis Splicing, Via Spliceosome
Pathways		Polymerase switching on the C-strand of the telomere	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545)	Crohn's disease ( 23266558) CSF tryptophan concentration in tuberculous meningitis ( 29395996) Intraocular pressure ( 29617998) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269)
Interacting Genes		6 interacting genes: AP4M1 DSCC1 EIF4EBP1 PCNA RFC3 WBP4	66 interacting genes: ARGLU1 BUB3 CAPRIN1 CHERP CHTF8 CPSF6 CPSF7 CSDE1 DDX23 DDX3X DHX15 DHX38 DIAPH1 DMRTB1 DNM2 EFTUD2 EIF4ENIF1 EIF5B EWSR1 FAM50B FUS HLTF HNRNPK HNRNPU HTATSF1 ISY1 KHDRBS1 LARP4 NONO OGT PABPC1 PPIA PRPF3 PRPF4 PRPF40A PSPC1 RARS1 RBM22 RBM42 RBPMS SART1 SCAF4 SF1 SF3A1 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SNRNP27 SNRNP70 SNRPA SNRPB SNW1 SQSTM1 TCERG1 TFIP11 TIA1 WAS WBP11 WDR83 WIPF1 XRCC6 ZC2HC1A ZNF207
Entrez ID		54921	11193
HPRD ID		16797	16086
Ensembl ID		ENSG00000168802	ENSG00000120688
Uniprot IDs		P0CG13	O75554
PDB IDs			2DK1 2JXW 5O9Z 6AHD 7OS1 8H6K 8H6L 8Q7N 8QO9 8QPE 8QZS
Enriched GO Terms of Interacting Partners?		Positive Regulation Of DNA-directed DNA Polymerase Activity Positive Regulation Of DNA Biosynthetic Process Regulation Of DNA Biosynthetic Process Ctf18 RFC-like Complex DNA Clamp Loader Activity DNA Strand Elongation Involved In DNA Replication DNA Replication DNA Strand Elongation Single-stranded DNA Helicase Activity DNA Synthesis Involved In DNA Repair Positive Regulation Of DNA Metabolic Process Positive Regulation Of Catalytic Activity PCNA Complex Replisome DNA Biosynthetic Process Regulation Of DNA Metabolic Process PCNA-p21 Complex DNA Polymerase Processivity Factor Activity Regulation Of Catalytic Activity Regulation Of DNA Replication Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Mitotic Telomere Maintenance Via Semi-conservative Replication Dinucleotide Insertion Or Deletion Binding Protein Localization To Basolateral Plasma Membrane Post-translational Protein Acetylation Positive Regulation Of Deoxyribonuclease Activity DNA Metabolic Process Leading Strand Elongation AP-4 Adaptor Complex Maintenance Of Mitotic Sister Chromatid Cohesion DNA Replication Factor C Complex MutLalpha Complex Binding Telomere Maintenance Via Semi-conservative Replication Nucleic Acid Metabolic Process Eukaryotic Initiation Factor 4E Binding Estrous Cycle Golgi To Lysosome Transport Clathrin Adaptor Complex Nuclear Lamina Base-excision Repair, Gap-filling Golgi To Endosome Transport Translation Repressor Activity Nucleobase-containing Compound Metabolic Process Chromosome Organization MRNA Cis Splicing, Via Spliceosome Nuclear Replication Fork Response To L-glutamate Ovulation Cycle Golgi To Vacuole Transport Precatalytic Spliceosome	MRNA Processing MRNA Metabolic Process RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Binding Spliceosomal Complex RNA Processing RNA Metabolic Process Nucleic Acid Binding Catalytic Step 2 Spliceosome Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Nucleoplasm Nucleus Nuclear Speck U2-type Precatalytic Spliceosome Macromolecule Metabolic Process U4/U6 X U5 Tri-snRNP Complex MRNA Binding U2-type Prespliceosome Assembly U2 SnRNP U2-type Spliceosomal Complex Spliceosomal Complex Assembly Protein-RNA Complex Assembly Regulation Of RNA Splicing Regulation Of MRNA Metabolic Process Poly(A) Binding Protein-containing Complex Assembly Cellular Component Assembly Protein-containing Complex Organization Regulation Of MRNA Splicing, Via Spliceosome U12-type Spliceosomal Complex Regulation Of MRNA Processing Cytoplasmic Stress Granule MRNA 3'-splice Site Recognition MRNA Cis Splicing, Via Spliceosome U2-type Prespliceosome Membraneless Organelle Assembly Paraspeckles Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of MRNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Translation Pre-mRNA Binding Nuclear Matrix U1 SnRNP U1 SnRNP Binding Positive Regulation Of Translation Protein Binding
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