CHTF8 and EIF4EBP1

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CHTF8	EIF4EBP1
Gene Name		CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae)	eukaryotic translation initiation factor 4E binding protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Extracellular Vesicular Exosome	Nucleoplasm Cytoplasm Cytosol Protein Complex
	Molecular Function	DNA Binding	Protein Binding Eukaryotic Initiation Factor 4E Binding Translation Repressor Activity
	Biological Process	DNA Replication Cell Cycle	G1/S Transition Of Mitotic Cell Cycle IRES-dependent Translational Initiation Response To Ischemia Translation Translational Initiation Insulin Receptor Signaling Pathway Gene Expression Lung Development Negative Regulation Of Protein Complex Assembly TOR Signaling Cellular Protein Metabolic Process Response To Ethanol Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Translational Initiation
Pathways			IRS-mediated signalling mTOR signalling mTOR signalling mTORC1-mediated signalling IGF1R signaling cascade IRS-related events triggered by IGF1R Release of eIF4E Eukaryotic Translation Initiation PKB-mediated events Cap-dependent Translation Initiation PI3K Cascade Signaling by Insulin receptor Insulin receptor signalling cascade Translation IRS-related events Release of eIF4E mTORC1-mediated signalling IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S PKB-mediated events PI3K Cascade
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: AP4M1 DSCC1 EIF4EBP1 PCNA RFC3 WBP4	32 interactors: AKT1 ATM BUB1 CHTF8 CSNK2A1 CSNK2A2 EIF4E EIF4E2 GSK3B IRAK4 LATS1 LRRK2 MAPK1 MAPK14 MAPKAP1 MAPKAPK5 MLST8 MTOR MVD PPP2CA PPP2R4 PRKCA PRKDC REL RHEBL1 RICTOR RORC RPS6KA5 RPS6KB1 RPTOR STK3 TCF4
Entrez ID		54921	1978
HPRD ID		16797	03746
Ensembl ID		ENSG00000168802	ENSG00000187840
Uniprot IDs		P0CG13	Q13541
PDB IDs			1WKW 2JGB 2JGC 2V8W 2V8X 2V8Y 3HXG 3HXI 3M93 3M94 3U7X
Enriched GO Terms of Interacting Partners?		Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication Nuclear DNA Replication Telomere Maintenance Via Recombination Mitotic Cell Cycle Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening DNA Replication Transcription-coupled Nucleotide-excision Repair Cell Cycle Process Cell Cycle Telomere Maintenance Nucleotide-excision Repair Positive Regulation Of Deoxyribonuclease Activity DNA-dependent DNA Replication DNA Biosynthetic Process Regulation Of DNA Replication Mitotic Cell Cycle Process Leading Strand Elongation G1/S Transition Of Mitotic Cell Cycle Post-translational Protein Acetylation Maintenance Of Mitotic Sister Chromatid Cohesion IRES-dependent Translational Initiation Cap-independent Translational Initiation DNA Recombination Chromosome Organization DNA Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cytoplasmic Translational Initiation Translesion Synthesis Mitotic Sister Chromatid Cohesion Cytoplasmic Translation DNA Synthesis Involved In DNA Repair MRNA Cis Splicing, Via Spliceosome Golgi To Endosome Transport Negative Regulation Of Translational Initiation Postreplication Repair TOR Signaling Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Sister Chromatid Cohesion Response To Ischemia DNA Repair Cellular Homeostasis Positive Regulation Of Nuclease Activity Nucleobase-containing Compound Metabolic Process	Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Peptidyl-serine Phosphorylation Protein Phosphorylation Intracellular Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Protein Phosphorylation Phosphorylation Positive Regulation Of Protein Modification Process Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Cell Cycle Cellular Response To Organic Substance Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Signaling Cell Cycle Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Phosphorylation Cellular Protein Modification Process Regulation Of Protein Phosphorylation Cell Communication Phosphate-containing Compound Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Neurotrophin Signaling Pathway Cellular Protein Metabolic Process Regulation Of Signaling Regulation Of Phosphorus Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation Response To Heat Regulation Of Cellular Response To Heat Cellular Response To Fibroblast Growth Factor Stimulus Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Stimulus Response To Fibroblast Growth Factor Positive Regulation Of Metabolic Process Cellular Response To Growth Factor Stimulus Protein Metabolic Process Response To Growth Factor Negative Regulation Of Cellular Protein Metabolic Process Innate Immune Response Cell Death
Tagcloud ?			autophagy bcl2 birc5 buffer constituents damaged dataset degrades deregulation distant ero1l fos gapdh gse21653 gse3494 gse7390 inc itpr1 lived organelles periodicals prognostic proportional shortened signature starvation subgroups vegfa wiley
Tagcloud (Difference) ?			autophagy bcl2 birc5 buffer constituents damaged dataset degrades deregulation distant ero1l fos gapdh gse21653 gse3494 gse7390 inc itpr1 lived organelles periodicals prognostic proportional shortened signature starvation subgroups vegfa wiley
Tagcloud (Intersection) ?