CHTF8 and DSCC1

Number of citations: 97 (PubMedID 33961781)
Data Source: BioGRID (affinity chromatography technology), HPRD (in vivo, in vitro)

		CHTF8	DSCC1
Name		chromosome transmission fidelity factor 8	DNA replication and sister chromatid cohesion 1
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Ctf18 RFC-like Complex	Chromosome, Centromeric Region Chromatin Nucleus Nucleoplasm Ctf18 RFC-like Complex
	Molecular Function	DNA Binding DNA Clamp Loader Activity Protein Binding Single-stranded DNA Helicase Activity	DNA Binding DNA Clamp Loader Activity Protein Binding Single-stranded DNA Helicase Activity
	Biological Process	DNA Replication Mitotic Sister Chromatid Cohesion Positive Regulation Of DNA-directed DNA Polymerase Activity	DNA Replication Regulation Of DNA Replication Mitotic Sister Chromatid Cohesion Maintenance Of Mitotic Sister Chromatid Cohesion Post-translational Protein Acetylation Positive Regulation Of DNA-directed DNA Polymerase Activity
Pathways		Polymerase switching on the C-strand of the telomere	Polymerase switching on the C-strand of the telomere
GWAS		Body mass index ( 26426971 ) Brain morphology (MOSTest) ( 32665545 )	Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683 )
Interacting Genes		6 interacting genes: AP4M1 DSCC1 EIF4EBP1 PCNA RFC3 WBP4	2 interacting genes: CHTF8 PCNA
Entrez ID		54921	79075
HPRD ID		16797	13123
Ensembl ID		ENSG00000168802	ENSG00000136982
Uniprot IDs		P0CG13	Q9BVC3
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Positive Regulation Of DNA-directed DNA Polymerase Activity Positive Regulation Of DNA Biosynthetic Process Regulation Of DNA Biosynthetic Process Ctf18 RFC-like Complex DNA Clamp Loader Activity DNA Strand Elongation Involved In DNA Replication DNA Replication DNA Strand Elongation Single-stranded DNA Helicase Activity DNA Synthesis Involved In DNA Repair Positive Regulation Of DNA Metabolic Process Positive Regulation Of Catalytic Activity PCNA Complex Replisome DNA Biosynthetic Process Regulation Of DNA Metabolic Process PCNA-p21 Complex DNA Polymerase Processivity Factor Activity Regulation Of Catalytic Activity Regulation Of DNA Replication Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Mitotic Telomere Maintenance Via Semi-conservative Replication Dinucleotide Insertion Or Deletion Binding Protein Localization To Basolateral Plasma Membrane Post-translational Protein Acetylation Positive Regulation Of Deoxyribonuclease Activity DNA Metabolic Process Leading Strand Elongation AP-4 Adaptor Complex Maintenance Of Mitotic Sister Chromatid Cohesion DNA Replication Factor C Complex MutLalpha Complex Binding Telomere Maintenance Via Semi-conservative Replication Nucleic Acid Metabolic Process Eukaryotic Initiation Factor 4E Binding Estrous Cycle Golgi To Lysosome Transport Clathrin Adaptor Complex Nuclear Lamina Base-excision Repair, Gap-filling Golgi To Endosome Transport Translation Repressor Activity Nucleobase-containing Compound Metabolic Process Chromosome Organization MRNA Cis Splicing, Via Spliceosome Nuclear Replication Fork Response To L-glutamate Ovulation Cycle Golgi To Vacuole Transport Precatalytic Spliceosome	Positive Regulation Of DNA-directed DNA Polymerase Activity Positive Regulation Of DNA Biosynthetic Process Regulation Of DNA Biosynthetic Process PCNA Complex Replisome DNA Replication PCNA-p21 Complex DNA Polymerase Processivity Factor Activity Positive Regulation Of Catalytic Activity Positive Regulation Of DNA Metabolic Process Mitotic Telomere Maintenance Via Semi-conservative Replication Dinucleotide Insertion Or Deletion Binding Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Positive Regulation Of Deoxyribonuclease Activity Chromosome Organization Leading Strand Elongation Regulation Of DNA Metabolic Process MutLalpha Complex Binding Telomere Maintenance Via Semi-conservative Replication Ctf18 RFC-like Complex Regulation Of Catalytic Activity DNA Clamp Loader Activity Estrous Cycle Nuclear Lamina DNA Strand Elongation Involved In DNA Replication Base-excision Repair, Gap-filling DNA Metabolic Process DNA Strand Elongation Nuclear Replication Fork Response To L-glutamate Ovulation Cycle Mitotic Sister Chromatid Cohesion Single-stranded DNA Helicase Activity DNA Polymerase Binding Translesion Synthesis Histone Acetyltransferase Binding Replication Fork Liver Regeneration Mismatch Repair Postreplication Repair Replication Fork Processing Nuclear Estrogen Receptor Binding DNA Synthesis Involved In DNA Repair Positive Regulation Of DNA Replication Response To Cadmium Ion Sister Chromatid Cohesion Response To Dexamethasone Cyclin-dependent Protein Kinase Holoenzyme Complex Male Germ Cell Nucleus Animal Organ Regeneration