DUS2 and SMN1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		DUS2	SMN1
Description		dihydrouridine synthase 2	survival of motor neuron 1, telomeric
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol Cajal Body Nuclear Body Z Disc Axon SMN Complex SMN-Sm Protein Complex Cytoplasmic Ribonucleoprotein Granule Cell Projection Neuron Projection Perikaryon Gemini Of Cajal Bodies
	Molecular Function	TRNA Binding RNA Binding Double-stranded RNA Binding Protein Kinase Inhibitor Activity Protein Binding FMN Binding Oxidoreductase Activity TRNA Dihydrouridine Synthase Activity Flavin Adenine Dinucleotide Binding NADPH Binding TRNA-dihydrouridine20 Synthase Activity	RNA Binding Protein Binding Identical Protein Binding
	Biological Process	TRNA Dihydrouridine Synthesis TRNA Processing Antiviral Innate Immune Response	Spliceosomal Complex Assembly RNA Splicing, Via Transesterification Reactions Spliceosomal SnRNP Assembly DNA-templated Transcription Termination MRNA Processing Nervous System Development RNA Splicing
Pathways		tRNA modification in the nucleus and cytosol PKR-mediated signaling	snRNP Assembly SARS-CoV-2 modulates host translation machinery
Drugs			Nusinersen
Diseases			Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)
GWAS		Eosinophil count ( 32888494) Hemoglobin levels ( 32327693) Schizophrenia ( 29483656)
Interacting Genes		4 interacting genes: EPRS1 NECTIN2 SMN1 TK1	166 interacting genes: A1BG A2M ACTB ACTL6B ADAMTS10 AGAP1 ANXA2 APLP1 ARFGAP1 ATP5F1B ATP6V1A BAG6 BCL2 BLOC1S6 BYSL CARHSP1 CCDC90B CENPB CHTOP COIL COL4A2 COL4A5 COPS6 CPNE6 CRIP2 CSAD DDAH2 DDX20 DHX9 DMPK DOCK7 DUS2 DYNC1I1 EEF1A1 EEF1A2 EHHADH EIF3G EXT2 EZH2 FAM20C FAM9B FBL FGB FLAD1 FNDC11 FUBP1 FXR1 GAPDH GAR1 GDF9 GEMIN2 GEMIN5 GEMIN7 H3-4 HADHB HMGXB3 HNRNPR HNRNPU HNRNPUL1 IGHM ILF3 IMMT INPP5K IQUB ITCH JADE1 KDM1A KIF5A KLHL5 KMT2B KPNB1 KRTAP19-6 KRTAP19-7 KRTAP21-2 KRTAP6-1 KRTAP6-2 LENG8 LRIF1 LSM1 LSM10 LSM11 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 MAGED1 MAST2 MED31 MKI67 MPP1 MRPL37 MSH2 NEURL2 NGFR NKIRAS2 NMT2 NRN1 NTAQ1 OSTF1 PDE4DIP PKM PLXNA3 POLR1C POLR2A POP7 PPIG PSME1 QARS1 RBBP4 RBBP6 RBFOX2 RBM48 REX1BD RN7SL1 RNU1-1 RNU11 RNU2-1 RNU4-1 RPL13 RPS2 RXRA SCARNA1 SDF4 SELENOW SEMA5B SETDB1 SMC5 SMN2 SNORA81 SNRPB SNRPD1 SNRPD2 SNRPD3 SNRPE SNU13 SNUPN SP110 SPANXN2 STRAP STXBP2 STXBP3 SULT1A3 SUMO3 SYNCRIP TAF1C TERC TIAL1 TLE1 TMSB4X TP53 TRMT2A TUBA1A TUBB3 UCHL1 UNC119 USP4 VPS28 WDR18 WDR73 WIZ ZBTB16 ZNF431 ZRANB2 ZXDC
Entrez ID		54920	6606
HPRD ID		08624	02646
Ensembl ID		ENSG00000167264	ENSG00000172062
Uniprot IDs		B4DKP8 E7EUN9 Q9NX74	B4DP61 E7EQZ4 Q16637
PDB IDs		4WFS 4WFT 4XP7 5OC4 5OC5 5OC6 6EI8 6EZA 6EZB 6EZC 6F00	1G5V 1MHN 2LEH 4A4E 4A4G 4GLI 4QQ6 5XJL 5XJQ 5XJR 5XJS 5XJT 5XJU 7W2P 7W30
Enriched GO Terms of Interacting Partners?		Proline-tRNA Ligase Activity Glutamyl-tRNA Aminoacylation Prolyl-tRNA Aminoacylation Glutamate-tRNA Ligase Activity Identical Protein Binding Fusion Of Virus Membrane With Host Plasma Membrane Coreceptor-mediated Virion Attachment To Host Cell Cellular Anatomical Entity Morphogenesis Susceptibility To T Cell Mediated Cytotoxicity Susceptibility To Natural Killer Cell Mediated Cytotoxicity Sperm Mitochondrion Organization DNA Synthesis Involved In Mitotic DNA Replication Thymidine Kinase Activity GAIT Complex Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Thymidine Biosynthetic Process Positive Regulation Of Natural Killer Cell Mediated Immune Response To Tumor Cell Positive Regulation Of Mast Cell Activation Thymidine Metabolic Process Regulation Of Long-chain Fatty Acid Import Into Cell Zonula Adherens Deoxyribonucleoside Monophosphate Biosynthetic Process Macromolecule Biosynthetic Process Spermatid Nucleus Differentiation Aminoacyl-tRNA Synthetase Multienzyme Complex Virion Attachment To Host Cell SMN Complex Adhesion Of Symbiont To Host Cell Gemini Of Cajal Bodies Pyrimidine Nucleoside Metabolic Process Adhesion Of Symbiont To Host RNA Stem-loop Binding Positive Regulation Of Immune Response To Tumor Cell Regulation Of Mast Cell Activation Positive Regulation Of T Cell Receptor Signaling Pathway SMN-Sm Protein Complex DNA-templated Transcription Termination Regulation Of Viral Entry Into Host Cell Nucleic Acid Metabolic Process Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Cell-cell Contact Zone Regulation Of Fatty Acid Transport Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Apical Junction Complex Regulation Of Response To Tumor Cell Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Acrosome Assembly Establishment Of Mitochondrion Localization GTPase Binding TRNA Aminoacylation For Protein Translation	Spliceosomal SnRNP Assembly RNA Binding MRNA Metabolic Process RNA Splicing MRNA Processing RNA Splicing, Via Transesterification Reactions SMN-Sm Protein Complex RNA Processing Ribonucleoprotein Complex U4/U6 X U5 Tri-snRNP Complex Protein-RNA Complex Assembly MRNA Splicing, Via Spliceosome RNA Metabolic Process U2-type Precatalytic Spliceosome Spliceosomal Complex Lsm2-8 Complex Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process U6 SnRNP Lsm1-7-Pat1 Complex Nucleoplasm Precatalytic Spliceosome SMN Complex U4 SnRNP Catalytic Step 2 Spliceosome Telomerase Holoenzyme Complex U7 SnRNP Macromolecule Metabolic Process 7-methylguanosine Cap Hypermethylation Small Nuclear Ribonucleoprotein Complex Nucleus Gemini Of Cajal Bodies Methylosome U12-type Spliceosomal Complex PICln-Sm Protein Complex Spliceosomal Tri-snRNP Complex Cytosol U2 SnRNP Spliceosomal Complex Assembly Protein-containing Complex Assembly U1 SnRNP U7 SnRNA Binding U5 SnRNP Cytoplasm Cajal Body Histone Pre-mRNA DCP Binding U2-type Prespliceosome Assembly Protein-containing Complex Organization U6 SnRNA Binding Promoter-specific Chromatin Binding
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