DUS2 and NECTIN2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		DUS2	NECTIN2
Description		dihydrouridine synthase 2	nectin cell adhesion molecule 2
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol	Plasma Membrane Cell-cell Junction Zonula Adherens Focal Adhesion Cell Surface Membrane Apical Junction Complex Cell-cell Contact Zone Extracellular Exosome
	Molecular Function	TRNA Binding RNA Binding Double-stranded RNA Binding Protein Kinase Inhibitor Activity Protein Binding FMN Binding Oxidoreductase Activity TRNA Dihydrouridine Synthase Activity Flavin Adenine Dinucleotide Binding NADPH Binding TRNA-dihydrouridine20 Synthase Activity	Virus Receptor Activity Protein Binding Coreceptor Activity Identical Protein Binding Protein Homodimerization Activity Receptor Ligand Activity Cell Adhesion Molecule Binding
	Biological Process	TRNA Dihydrouridine Synthesis TRNA Processing Antiviral Innate Immune Response	Acrosome Assembly Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Immunoglobulin Mediated Immune Response Cytoskeleton Organization Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Signal Transduction Spermatid Development Spermatid Nucleus Differentiation Fertilization Fusion Of Virus Membrane With Host Plasma Membrane Sperm Mitochondrion Organization Cellular Anatomical Entity Morphogenesis Positive Regulation Of Mast Cell Activation Natural Killer Cell Mediated Cytotoxicity Susceptibility To Natural Killer Cell Mediated Cytotoxicity Adhesion Of Symbiont To Host Cilium Organization Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Viral Entry Into Host Cell Symbiont Entry Into Host Cell Coreceptor-mediated Virion Attachment To Host Cell Positive Regulation Of T Cell Receptor Signaling Pathway Establishment Of Localization In Cell Establishment Of Mitochondrion Localization Susceptibility To T Cell Mediated Cytotoxicity
Pathways		tRNA modification in the nucleus and cytosol PKR-mediated signaling	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adherens junctions interactions Nectin/Necl trans heterodimerization
Drugs
Diseases
GWAS		Eosinophil count ( 32888494) Hemoglobin levels ( 32327693) Schizophrenia ( 29483656)	Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 30498476) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Urate levels ( 31578528)
Interacting Genes		4 interacting genes: EPRS1 NECTIN2 SMN1 TK1	38 interacting genes: AFDN ATP5MF CD226 CYSRT1 DUS2 HOXA1 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP12-2 KRTAP5-9 LCE1C LCE1E LCE1F LCE2B LCE2C LCE5A LYRM4 MAPK6 MDFI MEOX2 NBPF19 NECTIN3 NECTIN4 NOTCH2NLA NR4A3 P4HB PICK1 RGS20 SIAH1 TCF4 TGM1 TIGIT USP53
Entrez ID		54920	5819
HPRD ID		08624	02879
Ensembl ID		ENSG00000167264	ENSG00000130202
Uniprot IDs		B4DKP8 E7EUN9 Q9NX74	Q92692
PDB IDs		4WFS 4WFT 4XP7 5OC4 5OC5 5OC6 6EI8 6EZA 6EZB 6EZC 6F00	3R0N 4DFH 4DFI 4HZA 5V52 8X6B
Enriched GO Terms of Interacting Partners?		Proline-tRNA Ligase Activity Glutamyl-tRNA Aminoacylation Prolyl-tRNA Aminoacylation Glutamate-tRNA Ligase Activity Identical Protein Binding Fusion Of Virus Membrane With Host Plasma Membrane Coreceptor-mediated Virion Attachment To Host Cell Cellular Anatomical Entity Morphogenesis Susceptibility To T Cell Mediated Cytotoxicity Susceptibility To Natural Killer Cell Mediated Cytotoxicity Sperm Mitochondrion Organization DNA Synthesis Involved In Mitotic DNA Replication Thymidine Kinase Activity GAIT Complex Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Thymidine Biosynthetic Process Positive Regulation Of Natural Killer Cell Mediated Immune Response To Tumor Cell Positive Regulation Of Mast Cell Activation Thymidine Metabolic Process Regulation Of Long-chain Fatty Acid Import Into Cell Zonula Adherens Deoxyribonucleoside Monophosphate Biosynthetic Process Macromolecule Biosynthetic Process Spermatid Nucleus Differentiation Aminoacyl-tRNA Synthetase Multienzyme Complex Virion Attachment To Host Cell SMN Complex Adhesion Of Symbiont To Host Cell Gemini Of Cajal Bodies Pyrimidine Nucleoside Metabolic Process Adhesion Of Symbiont To Host RNA Stem-loop Binding Positive Regulation Of Immune Response To Tumor Cell Regulation Of Mast Cell Activation Positive Regulation Of T Cell Receptor Signaling Pathway SMN-Sm Protein Complex DNA-templated Transcription Termination Regulation Of Viral Entry Into Host Cell Nucleic Acid Metabolic Process Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Cell-cell Contact Zone Regulation Of Fatty Acid Transport Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Apical Junction Complex Regulation Of Response To Tumor Cell Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Acrosome Assembly Establishment Of Mitochondrion Localization GTPase Binding TRNA Aminoacylation For Protein Translation	Identical Protein Binding Intermediate Filament Keratinization Epidermis Development Keratin Filament Cell Adhesion Mediator Activity Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Tissue Development Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Cell Adhesion Molecule Binding Positive Regulation Of Natural Killer Cell Mediated Immune Response To Tumor Cell Regulation Of Leukocyte Mediated Cytotoxicity Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Mast Cell Activation Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Natural Killer Cell Mediated Immunity Leukocyte Mediated Cytotoxicity Positive Regulation Of Immune Response To Tumor Cell Regulation Of Mast Cell Activation Adherens Junction Regulation Of Lymphocyte Mediated Immunity Negative Regulation Of Innate Immune Response Cell-cell Contact Zone Cochlea Morphogenesis Semicircular Canal Formation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Response To Tumor Cell Neuron Apoptotic Process Positive Regulation Of Mast Cell Activation By Fc-epsilon Receptor Signaling Pathway TRNA-dihydrouridine20 Synthase Activity L-cysteine Desulfurase Complex Symbiont Entry Into Host Cell Lymphocyte Mediated Immunity Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
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