DUS2

Description		dihydrouridine synthase 2
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol
	Molecular Function	TRNA Binding RNA Binding Double-stranded RNA Binding Protein Kinase Inhibitor Activity Protein Binding FMN Binding Oxidoreductase Activity TRNA Dihydrouridine Synthase Activity Flavin Adenine Dinucleotide Binding NADPH Binding TRNA-dihydrouridine20 Synthase Activity
	Biological Process	TRNA Dihydrouridine Synthesis TRNA Processing Antiviral Innate Immune Response
Pathways		tRNA modification in the nucleus and cytosol PKR-mediated signaling
Drugs
Diseases
GWAS		Eosinophil count ( 32888494) Hemoglobin levels ( 32327693) Schizophrenia ( 29483656)
Interacting Genes		4 interacting genes: EPRS1 NECTIN2 SMN1 TK1
Entrez ID		54920
HPRD ID		08624
Ensembl ID		ENSG00000167264
Uniprot IDs		B4DKP8 E7EUN9 Q9NX74
PDB IDs		4WFS 4WFT 4XP7 5OC4 5OC5 5OC6 6EI8 6EZA 6EZB 6EZC 6F00
Enriched GO Terms of Interacting Partners?		Proline-tRNA Ligase Activity Glutamyl-tRNA Aminoacylation Prolyl-tRNA Aminoacylation Glutamate-tRNA Ligase Activity Identical Protein Binding Fusion Of Virus Membrane With Host Plasma Membrane Coreceptor-mediated Virion Attachment To Host Cell Cellular Anatomical Entity Morphogenesis Susceptibility To T Cell Mediated Cytotoxicity Susceptibility To Natural Killer Cell Mediated Cytotoxicity Sperm Mitochondrion Organization DNA Synthesis Involved In Mitotic DNA Replication Thymidine Kinase Activity GAIT Complex Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Thymidine Biosynthetic Process Positive Regulation Of Natural Killer Cell Mediated Immune Response To Tumor Cell Positive Regulation Of Mast Cell Activation Thymidine Metabolic Process Regulation Of Long-chain Fatty Acid Import Into Cell Zonula Adherens Deoxyribonucleoside Monophosphate Biosynthetic Process Macromolecule Biosynthetic Process Spermatid Nucleus Differentiation Aminoacyl-tRNA Synthetase Multienzyme Complex Virion Attachment To Host Cell SMN Complex Adhesion Of Symbiont To Host Cell Gemini Of Cajal Bodies Pyrimidine Nucleoside Metabolic Process Adhesion Of Symbiont To Host RNA Stem-loop Binding Positive Regulation Of Immune Response To Tumor Cell Regulation Of Mast Cell Activation Positive Regulation Of T Cell Receptor Signaling Pathway SMN-Sm Protein Complex DNA-templated Transcription Termination Regulation Of Viral Entry Into Host Cell Nucleic Acid Metabolic Process Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Cell-cell Contact Zone Regulation Of Fatty Acid Transport Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Apical Junction Complex Regulation Of Response To Tumor Cell Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Acrosome Assembly Establishment Of Mitochondrion Localization GTPase Binding TRNA Aminoacylation For Protein Translation
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