DUS2 and EPRS1

Number of citations of the paper that reports this interaction (PubMedID 15994936)
0

Data Source:
HPRD (in vivo)

		DUS2	EPRS1
Description		dihydrouridine synthase 2	glutamyl-prolyl-tRNA synthetase 1
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol	Cytoplasm Cytosol Plasma Membrane Membrane Aminoacyl-tRNA Synthetase Multienzyme Complex GAIT Complex Ribonucleoprotein Complex
	Molecular Function	TRNA Binding RNA Binding Double-stranded RNA Binding Protein Kinase Inhibitor Activity Protein Binding FMN Binding Oxidoreductase Activity TRNA Dihydrouridine Synthase Activity Flavin Adenine Dinucleotide Binding NADPH Binding TRNA-dihydrouridine20 Synthase Activity	Nucleotide Binding RNA Binding Catalytic Activity Aminoacyl-tRNA Ligase Activity Glutamate-tRNA Ligase Activity Proline-tRNA Ligase Activity Protein Binding ATP Binding Zinc Ion Binding Ligase Activity RNA Stem-loop Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding GTPase Binding
	Biological Process	TRNA Dihydrouridine Synthesis TRNA Processing Antiviral Innate Immune Response	Translation Regulation Of Translation TRNA Aminoacylation For Protein Translation Glutamyl-tRNA Aminoacylation Prolyl-tRNA Aminoacylation Negative Regulation Of Translation Cellular Response To Insulin Stimulus TRNA Aminoacylation Cellular Response To Type II Interferon Regulation Of Long-chain Fatty Acid Import Into Cell
Pathways		tRNA modification in the nucleus and cytosol PKR-mediated signaling	Selenoamino acid metabolism Cytosolic tRNA aminoacylation tRNA modification in the nucleus and cytosol Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs			Glutamic acid Proline 5'-O-(L-Prolylsulfamoyl)adenosine 5'-O-(L-Cysteinylsulfamoyl)adenosine 5'-O-(N-(Alanyl)sulfamoyl)adenosine
Diseases
GWAS		Eosinophil count ( 32888494) Hemoglobin levels ( 32327693) Schizophrenia ( 29483656)
Interacting Genes		4 interacting genes: EPRS1 NECTIN2 SMN1 TK1	93 interacting genes: AIMP2 ARL4D BTG3 CDC42 CEBPA DUS2 DUX4 EEF1D HSP90AA1 HUNK IARS1 LINC01016 LINC01554 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NEDD4 NELFCD PTEN RARS1 RNF10 SUMO2 SYNCRIP TAB1
Entrez ID		54920	2058
HPRD ID		08624	00703
Ensembl ID		ENSG00000167264	ENSG00000136628
Uniprot IDs		B4DKP8 E7EUN9 Q9NX74	P07814
PDB IDs		4WFS 4WFT 4XP7 5OC4 5OC5 5OC6 6EI8 6EZA 6EZB 6EZC 6F00	1FYJ 4HVC 4K86 4K87 4K88 5A1N 5A34 5A5H 5BMU 5V58 5VAD 5Y6L 6IY6 7BBU 7F98 7F99 7F9A 7F9B 7F9C 7F9D 7OSY 7OSZ 7OT0 7OT1 7OT2 7OT3 7X09 7X1O 7Y1H 7Y1W 7Y28 7Y3S
Enriched GO Terms of Interacting Partners?		Proline-tRNA Ligase Activity Glutamyl-tRNA Aminoacylation Prolyl-tRNA Aminoacylation Glutamate-tRNA Ligase Activity Identical Protein Binding Fusion Of Virus Membrane With Host Plasma Membrane Coreceptor-mediated Virion Attachment To Host Cell Cellular Anatomical Entity Morphogenesis Susceptibility To T Cell Mediated Cytotoxicity Susceptibility To Natural Killer Cell Mediated Cytotoxicity Sperm Mitochondrion Organization DNA Synthesis Involved In Mitotic DNA Replication Thymidine Kinase Activity GAIT Complex Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Thymidine Biosynthetic Process Positive Regulation Of Natural Killer Cell Mediated Immune Response To Tumor Cell Positive Regulation Of Mast Cell Activation Thymidine Metabolic Process Regulation Of Long-chain Fatty Acid Import Into Cell Zonula Adherens Deoxyribonucleoside Monophosphate Biosynthetic Process Macromolecule Biosynthetic Process Spermatid Nucleus Differentiation Aminoacyl-tRNA Synthetase Multienzyme Complex Virion Attachment To Host Cell SMN Complex Adhesion Of Symbiont To Host Cell Gemini Of Cajal Bodies Pyrimidine Nucleoside Metabolic Process Adhesion Of Symbiont To Host RNA Stem-loop Binding Positive Regulation Of Immune Response To Tumor Cell Regulation Of Mast Cell Activation Positive Regulation Of T Cell Receptor Signaling Pathway SMN-Sm Protein Complex DNA-templated Transcription Termination Regulation Of Viral Entry Into Host Cell Nucleic Acid Metabolic Process Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Cell-cell Contact Zone Regulation Of Fatty Acid Transport Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Apical Junction Complex Regulation Of Response To Tumor Cell Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Acrosome Assembly Establishment Of Mitochondrion Localization GTPase Binding TRNA Aminoacylation For Protein Translation	MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Metabolic Process Extracellular Vesicle Negative Regulation Of Translation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Regulation Of Macromolecule Metabolic Process Negative Regulation Of Locomotion Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Cytokine Production Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Angiogenesis Regulation Of Vasculature Development Regulation Of MRNA Stability Regulation Of Metabolic Process Regulation Of Translation Regulation Of RNA Stability Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Developmental Process Negative Regulation Of Protein Metabolic Process Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cell Migration Regulation Of Endothelial Cell Migration Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Cell Motility Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Negative Regulation Of Endothelial Cell Migration Regulation Of MRNA Metabolic Process
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