SGTB and PPIB

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid, two hybrid)

		SGTB	PPIB
Description		small glutamine rich tetratricopeptide repeat co-chaperone beta	peptidylprolyl isomerase B
Image		No pdb structure
GO Annotations	Cellular Component	Membrane TRC Complex	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Smooth Endoplasmic Reticulum Cytosol Focal Adhesion Membrane Protein-containing Complex Endoplasmic Reticulum Chaperone Complex Melanosome Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Protein Binding Hsp70 Protein Binding Identical Protein Binding Protein-folding Chaperone Binding Molecular Adaptor Activity	RNA Binding Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Collagen Binding Cyclosporin A Binding Isomerase Activity Unfolded Protein Binding RNA Polymerase Binding
	Biological Process	Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Protein Homooligomerization Protein Heterooligomerization	Protein Folding Neutrophil Chemotaxis Positive Regulation Of Multicellular Organism Growth Host-mediated Activation Of Viral Process Host-mediated Activation Of Viral Genome Replication Protein Stabilization Bone Development Regulation Of Post-translational Protein Modification
Pathways			Collagen biosynthesis and modifying enzymes SARS-CoV-1 activates/modulates innate immune responses
Drugs			Proline 1,4-Dithiothreitol
Diseases			Osteogenesis imperfecta
GWAS		Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Intralaminar thalamic nuclei volume ( 34006833) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		116 interacting genes: ABCG4 ADAT2 ADIPOQ AGR2 AGR3 ASPH BTC C1QA C1QL4 C1QTNF5 C1QTNF6 C5orf46 CALR CCL3L3 CD200R1 CD3D CD68 CD79B CD99L2 CDH15 CDSN CMPK1 COL10A1 COL1A2 COLQ COMP CREB3L3 CSH1 CSH2 CTAG1A CTAG1B CYB5R1 DEFA6 DEXI DMKN ECM1 EFEMP2 EMCN ERP29 ETNK1 EVA1A FBN1 FGF21 FZD7 GALNT11 GGH GIP GPX7 GYPA HSP90B1 HSPA13 IL6R IL6ST ITPRIP ITPRIPL1 KCNE5 KRT1 LAMP3 LAT LCN2 LHB LMO2 MYDGF NAXD NME3 OSMR PAGE3 PDIA6 PGRMC1 PODXL PPIB PPIC PRAP1 PRB1 PRB3 PRB4 PRR4 PSORS1C2 RAI2 RCN1 RNASE10 RNF144A RNF144B RNF170 SDC4 SDF2L1 SELENOM SERPINE1 SERPINF1 SERPINI2 SGCA SGTA SHISA5 SIL1 SLPI SOD3 SPINK4 SPP1 SRGN SYT11 SYT4 TFF1 TMEM108 TMEM123 TMPO TMUB1 TNFRSF19 TNFSF13 TXNDC12 UBL4A UPK3A VEGFC VWC2 WFDC12 ZG16 ZG16B	24 interacting genes: APOB ATP12A BANP CAMLG CEBPA DNM2 ESR1 GLP1R H3-4 HSPA6 IRF3 MDM2 PEX19 PRH1 PRL SGTA SGTB STAT5A TP53 TRDN UBQLN1 UBQLN2 UBQLN4 VKORC1
Entrez ID		54557	5479
HPRD ID		18049	00458
Ensembl ID		ENSG00000197860	ENSG00000166794
Uniprot IDs		Q96EQ0	P23284
PDB IDs			1CYN 3ICH 3ICI 8K0F 8K0I 8K0M 8K17 8KC9
Enriched GO Terms of Interacting Partners?		Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Protein Binding Collagen Trimer Endoplasmic Reticulum Chaperone Complex Endoplasmic Reticulum Extracellular Matrix Protein Folding Smooth Endoplasmic Reticulum Extracellular Matrix Structural Constituent Serine-type Endopeptidase Inhibitor Activity Sarcoplasmic Reticulum Lumen Extracellular Exosome Interleukin-6 Binding Interleukin-6 Receptor Activity Oncostatin-M Receptor Complex Melanosome Response To Bacterium Hormone Activity Interleukin-6 Receptor Complex Ciliary Neurotrophic Factor Receptor Complex Oncostatin-M Receptor Activity Positive Regulation Of Transport Memory Response To Endoplasmic Reticulum Stress Defense Response To Bacterium Ciliary Neurotrophic Factor Receptor Activity Interleukin-11 Receptor Activity Interleukin-11 Binding Oncostatin-M-mediated Signaling Pathway Regulation Of Smooth Muscle Cell-matrix Adhesion Regulation Of Immune System Process Sequestering Of Calcium Ion Biomineral Tissue Development Basement Membrane Ciliary Neurotrophic Factor-mediated Signaling Pathway ERAD Pathway Growth Factor Activity Golgi Lumen Positive Regulation Of Acute Inflammatory Response Ciliary Neurotrophic Factor Receptor Binding Response To Stress Regulation Of Cell-substrate Adhesion	Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Identical Protein Binding TRC Complex Positive Regulation Of ERAD Pathway Regulation Of MiRNA Transcription Regulation Of Ubiquitin-dependent Protein Catabolic Process Cellular Response To Actinomycin D Regulation Of ERAD Pathway Protein-containing Complex Regulation Of MiRNA Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Response To Actinomycin D Cellular Response To UV-C Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Establishment Of Protein Localization Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Leukocyte Apoptotic Process Negative Regulation Of Proteolysis Autophagy Positive Regulation Of MiRNA Transcription Cellular Response To Antibiotic Regulation Of Cellular Response To Stress Response To Estrogen Positive Regulation Of MiRNA Metabolic Process Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Positive Regulation Of Macromolecule Metabolic Process Response To Stress Cardiac Septum Morphogenesis Regulation Of Macroautophagy Response To UV-C Establishment Of Protein Localization To Membrane Response To Hormone Autophagosome Tail-anchored Membrane Protein Insertion Into ER Membrane Cellular Response To Stress Enzyme Binding Myeloid Cell Apoptotic Process Cellular Response To Estrogen Stimulus Cytokine-mediated Signaling Pathway Regulation Of Response To Endoplasmic Reticulum Stress DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Response To Endoplasmic Reticulum Stress ERAD Pathway
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