PPIB and APOB

Number of citations of the paper that reports this interaction (PMID 12397072)
19

Data Source:
HPRD (in vitro)

		PPIB	APOB
Gene Name		peptidylprolyl isomerase B (cyclophilin B)	apolipoprotein B
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Lumen Smooth Endoplasmic Reticulum Focal Adhesion Membrane Macromolecular Complex Melanosome Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Cytoplasm Early Endosome Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Endosome Membrane Actin Cytoskeleton Clathrin-coated Endocytic Vesicle Membrane Endosome Lumen Mature Chylomicron Chylomicron Remnant Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle Intermediate-density Lipoprotein Particle Chylomicron Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome Endocytic Vesicle Lumen
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Collagen Binding Protein Complex Binding Peptide Binding Poly(A) RNA Binding Unfolded Protein Binding RNA Polymerase Binding	Protein Binding Phospholipid Binding Heparin Binding Cholesterol Transporter Activity Lipase Binding Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Protein Peptidyl-prolyl Isomerization Extracellular Matrix Organization Positive Regulation Of Multicellular Organism Growth Positive Regulation By Host Of Viral Process Positive Regulation By Host Of Viral Genome Replication Protein Stabilization Bone Development Chaperone-mediated Protein Folding Regulation Of Post-translational Protein Modification	Retinoid Metabolic Process In Utero Embryonic Development Triglyceride Mobilization Receptor-mediated Endocytosis Spermatogenesis Nervous System Development Blood Coagulation Phototransduction, Visible Light Cholesterol Metabolic Process Fertilization Response To Virus Response To Carbohydrate Post-embryonic Development Response To Selenium Ion Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Lipid Storage Positive Regulation Of Cholesterol Storage Triglyceride Catabolic Process Cholesterol Transport Sperm Motility Response To Lipopolysaccharide Cholesterol Efflux Low-density Lipoprotein Particle Remodeling Very-low-density Lipoprotein Particle Assembly Low-density Lipoprotein Particle Clearance Lipoprotein Metabolic Process Lipoprotein Biosynthetic Process Lipoprotein Catabolic Process Cholesterol Homeostasis Lipoprotein Transport Small Molecule Metabolic Process Regulation Of Cholesterol Biosynthetic Process Artery Morphogenesis Leukocyte Migration Transmembrane Transport Cellular Response To Tumor Necrosis Factor Cellular Response To Prostaglandin Stimulus
Pathways		Collagen formation Collagen biosynthesis and modifying enzymes	Lipoprotein metabolism LDL-mediated lipid transport Metabolism of lipids and lipoproteins Chylomicron-mediated lipid transport Lipid digestion, mobilization, and transport Diseases associated with visual transduction Cell surface interactions at the vascular wall Platelet homeostasis Visual phototransduction Scavenging by Class H Receptors Platelet sensitization by LDL Scavenging by Class F Receptors Scavenging by Class A Receptors Scavenging by Class B Receptors Orphan transporters Retinoid metabolism and transport
Drugs
Diseases
GWAS			Cardiovascular disease risk factors ( 21943158) Cholesterol, total ( 19060911 20686565) Erectile dysfunction and prostate cancer treatment ( 20932654) HDL cholesterol ( 20864672 19060911 20686565) Hypertriglyceridemia ( 20657596) LDL (oxidized) ( 23247145) LDL cholesterol ( 18262040 23726366 21059979 18193043 18193044 20864672 19060906 19060910 19060911 20686565) Lipid metabolism phenotypes ( 19936222) Lipoprotein-associated phospholipase A2 activity and mass ( 23118302) Metabolic syndrome ( 22399527) Metabolic traits ( 19060910) Metabolite levels ( 22916037) Response to statin therapy ( 20339536) Triglycerides ( 18193044 20864672 19060906 19060911 17463246 20686565)
Protein-Protein Interactions		15 interactors: APOB ATP12A BANP CAMLG DNM2 HIST3H3 IRF3 MDM2 PEX19 PRL SGTA STAT5A UBQLN1 UBQLN4 VKORC1	22 interactors: AKT2 APOA1 ARFGAP1 BGN CALR CANX HSP90AA1 HSP90B1 HSPA1A HSPA5 HSPA8 LDLR LIPC LRP2 LRP6 MTTP PDIA4 PPIB PRDX4 SEC61A2 SEC61B SMAD3
Entrez ID		5479	338
HPRD ID		00458	00133
Ensembl ID		ENSG00000166794	ENSG00000084674
Uniprot IDs		P23284	P04114 Q59HB3 Q7Z7Q0
PDB IDs		1CYN 3ICH 3ICI
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Mitotic Cell Cycle JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Response To Growth Hormone Viral Process Regulation Of Body Fluid Levels Cellular Response To Hormone Stimulus JAK-STAT Cascade Positive Regulation Of Mitotic Cell Cycle Phase Transition Lactation Positive Regulation Of Cell Cycle Phase Transition Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Cycle Negative Regulation Of Lipid Binding Negative Regulation Of Interferon-beta Biosynthetic Process Cellular Response To UV-C Positive Regulation Of Mast Cell Differentiation Cellular Response To Vitamin B1 Regulation Of Developmental Growth Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Receptor Metabolic Process Immune System Process Negative Regulation Of Membrane Tubulation MDA-5 Signaling Pathway Macrophage Apoptotic Process Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Steroid Metabolic Process Regulation Of Multicellular Organism Growth Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Mast Cell Differentiation Development Of Secondary Male Sexual Characteristics Regulation Of Mitotic Cell Cycle Regulation Of Cytokine Biosynthetic Process Body Fluid Secretion Cellular Response To Lipid Cellular Response To Oxygen Levels Response To Hormone Traversing Start Control Point Of Mitotic Cell Cycle Peroxisome Membrane Biogenesis Response To Peptide Hormone Cellular Response To Organonitrogen Compound Negative Regulation Of Mast Cell Apoptotic Process Response To Vitamin B1 Response To Ether Negative Regulation Of Defense Response To Virus By Host	Protein Folding Response To Unfolded Protein Receptor-mediated Endocytosis Protein Metabolic Process Chaperone-mediated Protein Folding Transport Cellular Protein Metabolic Process Vesicle-mediated Transport Protein Stabilization Plasma Lipoprotein Particle Clearance Endocytosis Regulation Of Protein Stability Protein Transport Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Nuclease Activity Establishment Of Protein Localization Protein Localization Regulation Of Plasma Lipoprotein Particle Levels Response To Endoplasmic Reticulum Stress Establishment Of Localization In Cell Cholesterol Transport Sterol Transport Protein Refolding Cholesterol Homeostasis Sterol Homeostasis Endoplasmic Reticulum Unfolded Protein Response Homeostatic Process Cellular Response To Unfolded Protein Cholesterol Import Cellular Localization Regulation Of Protein Phosphorylation Posttranscriptional Regulation Of Gene Expression ER-nucleus Signaling Pathway Regulation Of Cellular Response To Heat Regulation Of Phosphorus Metabolic Process Cellular Response To Topologically Incorrect Protein Response To Abiotic Stimulus Cellular Metabolic Process Lipid Homeostasis Cellular Response To Stress Response To Organic Substance Sequestering Of Calcium Ion Positive Regulation Of Cellular Metabolic Process Secretion By Cell Lipid Transport ER-associated Ubiquitin-dependent Protein Catabolic Process Chemical Homeostasis Lipid Localization Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Regulation Of Phosphorylation
Tagcloud ?		abeta abundance accompanies ad animal biomarkers cytokines diverse elisa immunostaining isotope key labeling lack lc microglia microglial ms nervous neurodegenerative neuroinflammation pdia3 pdia6 proper proteomic resident serpinh1 silac validation	apobec apolipoprotein appreciated auxiliary catalyzed chelating demonstration edit editing editosome ef1 ef2 exogenously hemagglutinin his6 linking mcardle mooring multiplicity p100 p240 p44 p66 presumptive quantitatively reconstituted tagged underscore virtually
Tagcloud (Difference) ?		abeta abundance accompanies ad animal biomarkers cytokines diverse elisa immunostaining isotope key labeling lack lc microglia microglial ms nervous neurodegenerative neuroinflammation pdia3 pdia6 proper proteomic resident serpinh1 silac validation	apobec apolipoprotein appreciated auxiliary catalyzed chelating demonstration edit editing editosome ef1 ef2 exogenously hemagglutinin his6 linking mcardle mooring multiplicity p100 p240 p44 p66 presumptive quantitatively reconstituted tagged underscore virtually
Tagcloud (Intersection) ?