SGTB and CDH15

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SGTB	CDH15
Description		small glutamine rich tetratricopeptide repeat co-chaperone beta	cadherin 15
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Membrane TRC Complex	Golgi Apparatus Plasma Membrane Caveola Adherens Junction Membrane Catenin Complex Neuromuscular Junction Extracellular Exosome
	Molecular Function	Protein Binding Hsp70 Protein Binding Identical Protein Binding Protein-folding Chaperone Binding Molecular Adaptor Activity	Calcium Ion Binding Protein Binding Beta-catenin Binding Cadherin Binding Metal Ion Binding
	Biological Process	Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Protein Homooligomerization Protein Heterooligomerization	Cell Morphogenesis Cell-cell Junction Assembly Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Migration Adherens Junction Organization Cell-cell Adhesion Mediated By Cadherin Cell-cell Adhesion
Pathways			Adherens junctions interactions Myogenesis Myogenesis
Drugs
Diseases			Non-syndromic autosomal dominant mental retardation
GWAS		Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Intralaminar thalamic nuclei volume ( 34006833) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		116 interacting genes: ABCG4 ADAT2 ADIPOQ AGR2 AGR3 ASPH BTC C1QA C1QL4 C1QTNF5 C1QTNF6 C5orf46 CALR CCL3L3 CD200R1 CD3D CD68 CD79B CD99L2 CDH15 CDSN CMPK1 COL10A1 COL1A2 COLQ COMP CREB3L3 CSH1 CSH2 CTAG1A CTAG1B CYB5R1 DEFA6 DEXI DMKN ECM1 EFEMP2 EMCN ERP29 ETNK1 EVA1A FBN1 FGF21 FZD7 GALNT11 GGH GIP GPX7 GYPA HSP90B1 HSPA13 IL6R IL6ST ITPRIP ITPRIPL1 KCNE5 KRT1 LAMP3 LAT LCN2 LHB LMO2 MYDGF NAXD NME3 OSMR PAGE3 PDIA6 PGRMC1 PODXL PPIB PPIC PRAP1 PRB1 PRB3 PRB4 PRR4 PSORS1C2 RAI2 RCN1 RNASE10 RNF144A RNF144B RNF170 SDC4 SDF2L1 SELENOM SERPINE1 SERPINF1 SERPINI2 SGCA SGTA SHISA5 SIL1 SLPI SOD3 SPINK4 SPP1 SRGN SYT11 SYT4 TFF1 TMEM108 TMEM123 TMPO TMUB1 TNFRSF19 TNFSF13 TXNDC12 UBL4A UPK3A VEGFC VWC2 WFDC12 ZG16 ZG16B	12 interacting genes: ARVCF BOC CDH7 CDH9 CDON CTNNA1 CTNNB1 GNA12 JUP SGTA SGTB UBQLN2
Entrez ID		54557	1013
HPRD ID		18049	00225
Ensembl ID		ENSG00000197860	ENSG00000129910
Uniprot IDs		Q96EQ0	P55291
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Protein Binding Collagen Trimer Endoplasmic Reticulum Chaperone Complex Endoplasmic Reticulum Extracellular Matrix Protein Folding Smooth Endoplasmic Reticulum Extracellular Matrix Structural Constituent Serine-type Endopeptidase Inhibitor Activity Sarcoplasmic Reticulum Lumen Extracellular Exosome Interleukin-6 Binding Interleukin-6 Receptor Activity Oncostatin-M Receptor Complex Melanosome Response To Bacterium Hormone Activity Interleukin-6 Receptor Complex Ciliary Neurotrophic Factor Receptor Complex Oncostatin-M Receptor Activity Positive Regulation Of Transport Memory Response To Endoplasmic Reticulum Stress Defense Response To Bacterium Ciliary Neurotrophic Factor Receptor Activity Interleukin-11 Receptor Activity Interleukin-11 Binding Oncostatin-M-mediated Signaling Pathway Regulation Of Smooth Muscle Cell-matrix Adhesion Regulation Of Immune System Process Sequestering Of Calcium Ion Biomineral Tissue Development Basement Membrane Ciliary Neurotrophic Factor-mediated Signaling Pathway ERAD Pathway Growth Factor Activity Golgi Lumen Positive Regulation Of Acute Inflammatory Response Ciliary Neurotrophic Factor Receptor Binding Response To Stress Regulation Of Cell-substrate Adhesion	Catenin Complex Cell-cell Adhesion Adherens Junction Cellular Response To Indole-3-methanol Response To Indole-3-methanol Cell-cell Junction Assembly Cell Adhesion Cadherin Binding Cell-cell Junction Organization TRC Complex Cell Junction Assembly Catenin-TCF7L2 Complex Cell-cell Adhesion Mediated By Cadherin Regulation Of Neuroblast Proliferation Neuroblast Proliferation Intercalated Disc Adherens Junction Organization Cell Junction Organization Zonula Adherens Flotillin Complex Alpha-catenin Binding Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Regulation Of Neural Precursor Cell Proliferation Neural Precursor Cell Proliferation Beta-catenin Binding Plasma Membrane Epithelial Cell-cell Adhesion Positive Regulation Of ERAD Pathway Positive Regulation Of Skeletal Muscle Tissue Development Positive Regulation Of Striated Muscle Tissue Development Anchoring Junction Regulation Of Skeletal Muscle Tissue Development Regulation Of ERAD Pathway Focal Adhesion Positive Regulation Of Neuroblast Proliferation Protein Targeting To ER Cell Migration Anatomical Structure Morphogenesis Establishment Of Protein Localization To Endoplasmic Reticulum Cell Morphogenesis Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Membrane Cell-cell Junction Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Striated Muscle Tissue Development Cellular Component Assembly Detection Of Mechanical Stimulus Regulation Of Muscle Organ Development Protein-DNA Complex
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