SGTB and PODXL

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SGTB	PODXL
Description		small glutamine rich tetratricopeptide repeat co-chaperone beta	podocalyxin like
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Membrane TRC Complex	Ruffle Extracellular Space Nucleolus Cytoplasm Endoplasmic Reticulum Plasma Membrane Microvillus Membrane Apical Plasma Membrane Lamellipodium Filopodium Microvillus Membrane Centriolar Satellite Slit Diaphragm Cell Projection Membrane Raft Extracellular Exosome
	Molecular Function	Protein Binding Hsp70 Protein Binding Identical Protein Binding Protein-folding Chaperone Binding Molecular Adaptor Activity	Protein Binding
	Biological Process	Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Protein Homooligomerization Protein Heterooligomerization	Cell Adhesion Negative Regulation Of Cell Adhesion Cell Migration Regulation Of Cell-cell Adhesion Negative Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Migration Regulation Of Microvillus Assembly Positive Regulation Of Cell-cell Adhesion Mediated By Integrin Podocyte Development Epithelial Tube Formation
Pathways
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Intralaminar thalamic nuclei volume ( 34006833) Subcortical volume (MOSTest) ( 32665545)	Alcohol dependence symptom count ( 27151647) Diastolic blood pressure ( 27841878) Femur bone mineral density x serum urate levels interaction ( 34046847) Hypertension ( 28273873) Idiopathic dilated cardiomyopathy ( 29495422) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Pulse pressure ( 30578418) Schizophrenia ( 25056061) Systolic blood pressure ( 27841878 30578418)
Interacting Genes		116 interacting genes: ABCG4 ADAT2 ADIPOQ AGR2 AGR3 ASPH BTC C1QA C1QL4 C1QTNF5 C1QTNF6 C5orf46 CALR CCL3L3 CD200R1 CD3D CD68 CD79B CD99L2 CDH15 CDSN CMPK1 COL10A1 COL1A2 COLQ COMP CREB3L3 CSH1 CSH2 CTAG1A CTAG1B CYB5R1 DEFA6 DEXI DMKN ECM1 EFEMP2 EMCN ERP29 ETNK1 EVA1A FBN1 FGF21 FZD7 GALNT11 GGH GIP GPX7 GYPA HSP90B1 HSPA13 IL6R IL6ST ITPRIP ITPRIPL1 KCNE5 KRT1 LAMP3 LAT LCN2 LHB LMO2 MYDGF NAXD NME3 OSMR PAGE3 PDIA6 PGRMC1 PODXL PPIB PPIC PRAP1 PRB1 PRB3 PRB4 PRR4 PSORS1C2 RAI2 RCN1 RNASE10 RNF144A RNF144B RNF170 SDC4 SDF2L1 SELENOM SERPINE1 SERPINF1 SERPINI2 SGCA SGTA SHISA5 SIL1 SLPI SOD3 SPINK4 SPP1 SRGN SYT11 SYT4 TFF1 TMEM108 TMEM123 TMPO TMUB1 TNFRSF19 TNFSF13 TXNDC12 UBL4A UPK3A VEGFC VWC2 WFDC12 ZG16 ZG16B	5 interacting genes: NHERF2 SELL SGTA SGTB UBQLN2
Entrez ID		54557	5420
HPRD ID		18049	04025
Ensembl ID		ENSG00000197860	ENSG00000128567
Uniprot IDs		Q96EQ0	O00592 Q96N83
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Protein Binding Collagen Trimer Endoplasmic Reticulum Chaperone Complex Endoplasmic Reticulum Extracellular Matrix Protein Folding Smooth Endoplasmic Reticulum Extracellular Matrix Structural Constituent Serine-type Endopeptidase Inhibitor Activity Sarcoplasmic Reticulum Lumen Extracellular Exosome Interleukin-6 Binding Interleukin-6 Receptor Activity Oncostatin-M Receptor Complex Melanosome Response To Bacterium Hormone Activity Interleukin-6 Receptor Complex Ciliary Neurotrophic Factor Receptor Complex Oncostatin-M Receptor Activity Positive Regulation Of Transport Memory Response To Endoplasmic Reticulum Stress Defense Response To Bacterium Ciliary Neurotrophic Factor Receptor Activity Interleukin-11 Receptor Activity Interleukin-11 Binding Oncostatin-M-mediated Signaling Pathway Regulation Of Smooth Muscle Cell-matrix Adhesion Regulation Of Immune System Process Sequestering Of Calcium Ion Biomineral Tissue Development Basement Membrane Ciliary Neurotrophic Factor-mediated Signaling Pathway ERAD Pathway Growth Factor Activity Golgi Lumen Positive Regulation Of Acute Inflammatory Response Ciliary Neurotrophic Factor Receptor Binding Response To Stress Regulation Of Cell-substrate Adhesion	TRC Complex Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Molecular Adaptor Activity Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of Response To Endoplasmic Reticulum Stress Protein Targeting To Membrane Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Localization Within Membrane Positive Regulation Of Proteasomal Protein Catabolic Process Type 2 Metabotropic Glutamate Receptor Binding Negative Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Type 3 Metabotropic Glutamate Receptor Binding BAT3 Complex Binding Identical Protein Binding Negative Regulation Of Clathrin-dependent Endocytosis Glycosphingolipid Binding Positive Regulation Of Proteolysis Establishment Of Protein Localization To Membrane Protein Targeting Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of ERAD Pathway Response To Endoplasmic Reticulum Stress Oligosaccharide Binding Establishment Of Protein Localization To Organelle Tail-anchored Membrane Protein Insertion Into ER Membrane Negative Regulation Of Receptor Internalization Regulation Of Clathrin-dependent Endocytosis Leukocyte Tethering Or Rolling Regulation Of Protein Catabolic Process Regulation Of Proteolysis Sialic Acid Binding Leukocyte Adhesion To Vascular Endothelial Cell Protein Heterooligomerization Protein Insertion Into ER Membrane Proteasomal Protein Catabolic Process Negative Regulation Of Receptor-mediated Endocytosis Mitochondrial Small Ribosomal Subunit Cellular Localization Protein-membrane Adaptor Activity
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