SGTB and FBN1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SGTB	FBN1
Description		small glutamine rich tetratricopeptide repeat co-chaperone beta	fibrillin 1
Image		No pdb structure
GO Annotations	Cellular Component	Membrane TRC Complex	Microfibril Extracellular Region Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	Protein Binding Hsp70 Protein Binding Identical Protein Binding Protein-folding Chaperone Binding Molecular Adaptor Activity	Integrin Binding Hormone Activity Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Heparin Binding Extracellular Matrix Constituent Conferring Elasticity Identical Protein Binding Protein-containing Complex Binding
	Biological Process	Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Protein Homooligomerization Protein Heterooligomerization	Skeletal System Development Metanephros Development Kidney Development Glucose Metabolic Process Signal Transduction Heart Development Gene Expression Protein Kinase A Signaling Lung Development Positive Regulation Of Appetite Cell Adhesion Mediated By Integrin Activation Of Protein Kinase A Activity Sequestering Of BMP In Extracellular Matrix Sequestering Of TGFbeta In Extracellular Matrix Glucose Homeostasis Camera-type Eye Development Negative Regulation Of Osteoclast Differentiation Embryonic Eye Morphogenesis Post-embryonic Eye Morphogenesis Lung Alveolus Development Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To Insulin-like Growth Factor Stimulus Negative Regulation Of Osteoclast Development
Pathways			Degradation of the extracellular matrix Degradation of the extracellular matrix Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres Integrin cell surface interactions TGF-beta receptor signaling activates SMADs Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases			Geleophysic dysplasia Weill-Marchesani syndrome, including: Weill-Marchesani syndrome; Weill-Marchesani-like syndrome Shprintzen-Goldberg syndrome Ectopia lentis MASS phenotype Marfan syndrome, including: Marfan syndrome (MFS); Neonatal MFS; Atypically severe MFS; New variant of MFS
GWAS		Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Intralaminar thalamic nuclei volume ( 34006833) Subcortical volume (MOSTest) ( 32665545)	Breast cancer ( 17903305) Central corneal thickness ( 32528159 29760442) Height ( 32499652 31562340) Hepcidin/ferritin ratio ( 27846281) Hip circumference adjusted for BMI ( 34021172 28552196) Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy) ( 27418160) Intraocular pressure ( 29617998) Macular thickness ( 30535121) Pulse pressure ( 28739976 30578418 27841878) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Refractive error ( 32231278) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Spontaneous coronary artery dissection ( 32374345) Systolic blood pressure ( 27841878 30578418) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Thoracic aortic aneurysms and dissections ( 21909107) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		116 interacting genes: ABCG4 ADAT2 ADIPOQ AGR2 AGR3 ASPH BTC C1QA C1QL4 C1QTNF5 C1QTNF6 C5orf46 CALR CCL3L3 CD200R1 CD3D CD68 CD79B CD99L2 CDH15 CDSN CMPK1 COL10A1 COL1A2 COLQ COMP CREB3L3 CSH1 CSH2 CTAG1A CTAG1B CYB5R1 DEFA6 DEXI DMKN ECM1 EFEMP2 EMCN ERP29 ETNK1 EVA1A FBN1 FGF21 FZD7 GALNT11 GGH GIP GPX7 GYPA HSP90B1 HSPA13 IL6R IL6ST ITPRIP ITPRIPL1 KCNE5 KRT1 LAMP3 LAT LCN2 LHB LMO2 MYDGF NAXD NME3 OSMR PAGE3 PDIA6 PGRMC1 PODXL PPIB PPIC PRAP1 PRB1 PRB3 PRB4 PRR4 PSORS1C2 RAI2 RCN1 RNASE10 RNF144A RNF144B RNF170 SDC4 SDF2L1 SELENOM SERPINE1 SERPINF1 SERPINI2 SGCA SGTA SHISA5 SIL1 SLPI SOD3 SPINK4 SPP1 SRGN SYT11 SYT4 TFF1 TMEM108 TMEM123 TMPO TMUB1 TNFRSF19 TNFSF13 TXNDC12 UBL4A UPK3A VEGFC VWC2 WFDC12 ZG16 ZG16B	18 interacting genes: ATXN7 CALR DCN DYRK1A ELN FBLN2 FBN2 GET4 HGS HOXA1 HSPG2 LTBP1 MFAP2 MFAP5 MYOC SGTB SPRY2 VCAN
Entrez ID		54557	2200
HPRD ID		18049	00618
Ensembl ID		ENSG00000197860	ENSG00000166147
Uniprot IDs		Q96EQ0	P35555
PDB IDs			1APJ 1EMN 1EMO 1LMJ 1UZJ 1UZK 1UZP 1UZQ 2M74 2W86 5MS9
Enriched GO Terms of Interacting Partners?		Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Protein Binding Collagen Trimer Endoplasmic Reticulum Chaperone Complex Endoplasmic Reticulum Extracellular Matrix Protein Folding Smooth Endoplasmic Reticulum Extracellular Matrix Structural Constituent Serine-type Endopeptidase Inhibitor Activity Sarcoplasmic Reticulum Lumen Extracellular Exosome Interleukin-6 Binding Interleukin-6 Receptor Activity Oncostatin-M Receptor Complex Melanosome Response To Bacterium Hormone Activity Interleukin-6 Receptor Complex Ciliary Neurotrophic Factor Receptor Complex Oncostatin-M Receptor Activity Positive Regulation Of Transport Memory Response To Endoplasmic Reticulum Stress Defense Response To Bacterium Ciliary Neurotrophic Factor Receptor Activity Interleukin-11 Receptor Activity Interleukin-11 Binding Oncostatin-M-mediated Signaling Pathway Regulation Of Smooth Muscle Cell-matrix Adhesion Regulation Of Immune System Process Sequestering Of Calcium Ion Biomineral Tissue Development Basement Membrane Ciliary Neurotrophic Factor-mediated Signaling Pathway ERAD Pathway Growth Factor Activity Golgi Lumen Positive Regulation Of Acute Inflammatory Response Ciliary Neurotrophic Factor Receptor Binding Response To Stress Regulation Of Cell-substrate Adhesion	Microfibril Extracellular Matrix Extracellular Matrix Structural Constituent Extracellular Matrix Constituent Conferring Elasticity Extracellular Matrix Structural Constituent Conferring Compression Resistance Negative Regulation Of Supramolecular Fiber Organization Sequestering Of TGFbeta In Extracellular Matrix Embryonic Eye Morphogenesis Regulation Of Cellular Response To Growth Factor Stimulus Extracellular Matrix Binding Protein-folding Chaperone Binding Extracellular Region Regulation Of Supramolecular Fiber Organization Negative Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Positive Regulation Of Mitochondrial Depolarization Negative Regulation Of Cytoskeleton Organization Sequestering Of Extracellular Ligand From Receptor Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Eye Morphogenesis Animal Organ Morphogenesis Extracellular Negative Regulation Of Signal Transduction Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Sensory Organ Morphogenesis Positive Regulation Of Membrane Depolarization Calcium Ion Binding Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Maintenance Of Location Regulation Of Trophoblast Cell Migration Negative Regulation Of Cellular Response To Vascular Endothelial Growth Factor Stimulus Lysosomal Lumen Embryonic Morphogenesis Golgi Lumen Regulation Of Mitochondrial Depolarization Glycosaminoglycan Binding Negative Regulation Of Cellular Component Organization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Cell-substrate Adhesion Negative Regulation Of Cellular Response To Growth Factor Stimulus Embryonic Organ Morphogenesis Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Fibronectin Binding Protein Targeting To ER Regulation Of Cytoskeleton Organization Establishment Of Protein Localization To Endoplasmic Reticulum Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Protein Metabolic Process
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