SGTB and LHB

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SGTB	LHB
Description		small glutamine rich tetratricopeptide repeat co-chaperone beta	luteinizing hormone subunit beta
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Membrane TRC Complex	Extracellular Region Extracellular Space Cytoplasm Golgi Lumen Pituitary Gonadotropin Complex
	Molecular Function	Protein Binding Hsp70 Protein Binding Identical Protein Binding Protein-folding Chaperone Binding Molecular Adaptor Activity	Signaling Receptor Binding Hormone Activity Protein Binding
	Biological Process	Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Protein Homooligomerization Protein Heterooligomerization	Progesterone Biosynthetic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Male Gonad Development Hormone-mediated Signaling Pathway
Pathways			Androgen biosynthesis Mineralocorticoid biosynthesis Glycoprotein hormones Hormone ligand-binding receptors G alpha (s) signalling events Reactions specific to the complex N-glycan synthesis pathway
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Intralaminar thalamic nuclei volume ( 34006833) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		116 interacting genes: ABCG4 ADAT2 ADIPOQ AGR2 AGR3 ASPH BTC C1QA C1QL4 C1QTNF5 C1QTNF6 C5orf46 CALR CCL3L3 CD200R1 CD3D CD68 CD79B CD99L2 CDH15 CDSN CMPK1 COL10A1 COL1A2 COLQ COMP CREB3L3 CSH1 CSH2 CTAG1A CTAG1B CYB5R1 DEFA6 DEXI DMKN ECM1 EFEMP2 EMCN ERP29 ETNK1 EVA1A FBN1 FGF21 FZD7 GALNT11 GGH GIP GPX7 GYPA HSP90B1 HSPA13 IL6R IL6ST ITPRIP ITPRIPL1 KCNE5 KRT1 LAMP3 LAT LCN2 LHB LMO2 MYDGF NAXD NME3 OSMR PAGE3 PDIA6 PGRMC1 PODXL PPIB PPIC PRAP1 PRB1 PRB3 PRB4 PRR4 PSORS1C2 RAI2 RCN1 RNASE10 RNF144A RNF144B RNF170 SDC4 SDF2L1 SELENOM SERPINE1 SERPINF1 SERPINI2 SGCA SGTA SHISA5 SIL1 SLPI SOD3 SPINK4 SPP1 SRGN SYT11 SYT4 TFF1 TMEM108 TMEM123 TMPO TMUB1 TNFRSF19 TNFSF13 TXNDC12 UBL4A UPK3A VEGFC VWC2 WFDC12 ZG16 ZG16B	7 interacting genes: CGA FHL3 GNAI2 GNAS LHCGR NTM SGTB
Entrez ID		54557	3972
HPRD ID		18049	01072
Ensembl ID		ENSG00000197860	ENSG00000104826
Uniprot IDs		Q96EQ0	A0A0F7RQE6 P01229
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Protein Binding Collagen Trimer Endoplasmic Reticulum Chaperone Complex Endoplasmic Reticulum Extracellular Matrix Protein Folding Smooth Endoplasmic Reticulum Extracellular Matrix Structural Constituent Serine-type Endopeptidase Inhibitor Activity Sarcoplasmic Reticulum Lumen Extracellular Exosome Interleukin-6 Binding Interleukin-6 Receptor Activity Oncostatin-M Receptor Complex Melanosome Response To Bacterium Hormone Activity Interleukin-6 Receptor Complex Ciliary Neurotrophic Factor Receptor Complex Oncostatin-M Receptor Activity Positive Regulation Of Transport Memory Response To Endoplasmic Reticulum Stress Defense Response To Bacterium Ciliary Neurotrophic Factor Receptor Activity Interleukin-11 Receptor Activity Interleukin-11 Binding Oncostatin-M-mediated Signaling Pathway Regulation Of Smooth Muscle Cell-matrix Adhesion Regulation Of Immune System Process Sequestering Of Calcium Ion Biomineral Tissue Development Basement Membrane Ciliary Neurotrophic Factor-mediated Signaling Pathway ERAD Pathway Growth Factor Activity Golgi Lumen Positive Regulation Of Acute Inflammatory Response Ciliary Neurotrophic Factor Receptor Binding Response To Stress Regulation Of Cell-substrate Adhesion	Guanyl Nucleotide Binding Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway G-protein Beta/gamma-subunit Complex Binding Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Heterotrimeric G-protein Complex Ovulation Cycle Process G Protein-coupled Receptor Signaling Pathway Cellular Response To Hormone Stimulus Choriogonadotropin Hormone Binding Choriogonadotropin Hormone Receptor Activity Luteinizing Hormone Receptor Activity Regulation Of Steroid Biosynthetic Process Follicle-stimulating Hormone Secretion Follicle-stimulating Hormone Activity Negative Regulation Of Developmental Growth Regulation Of Steroid Metabolic Process Follicle-stimulating Hormone Complex Mu-type Opioid Receptor Binding Luteinizing Hormone Signaling Pathway TRC Complex Regulation Of Hormone Levels Renal System Process Pituitary Gonadotropin Complex Follicle-stimulating Hormone Signaling Pathway Animal Organ Development Gonad Development Development Of Secondary Male Sexual Characteristics Luteinizing Hormone Secretion Response To Hormone Hormone-mediated Signaling Pathway Corticotropin-releasing Hormone Receptor 1 Binding Adenylate Cyclase Regulator Activity Positive Regulation Of Inositol Trisphosphate Biosynthetic Process Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Hair Follicle Placode Formation Adenylate Cyclase Activator Activity Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway Cellular Response To Luteinizing Hormone Stimulus Regulation Of Inositol Trisphosphate Biosynthetic Process Cellular Response To Peptide Hormone Stimulus Gonadotropin Secretion Regulation Of Lipid Biosynthetic Process Reproductive Structure Development Beta-2 Adrenergic Receptor Binding Development Of Secondary Sexual Characteristics D1 Dopamine Receptor Binding Response To Luteinizing Hormone Negative Regulation Of Growth Rhythmic Process Positive Regulation Of Urine Volume
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