SGTB and DMKN

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		SGTB	DMKN
Name		small glutamine rich tetratricopeptide repeat co-chaperone beta	dermokine
Structure		No pdb structure
GO Annotations	Cellular Component	Membrane TRC Complex	Extracellular Region Extracellular Space
	Molecular Function	Protein Binding Hsp70 Protein Binding Identical Protein Binding Protein-folding Chaperone Binding Molecular Adaptor Activity	Protein Binding
	Biological Process	Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Protein Homooligomerization Protein Heterooligomerization	Cornified Envelope Assembly
Pathways		None	Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
GWAS		Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Intralaminar thalamic nuclei volume ( 34006833 ) Subcortical volume (MOSTest) ( 32665545 )	Antipsychotic drug-induced weight gain in schizophrenia ( 31447353 ) Perceived intensity of neohesperidin dihydrochalcone ( 31005972 ) Waist circumference adjusted for body mass index ( 28552196 )
Interacting Genes		116 interacting genes: ABCG4 ADAT2 ADIPOQ AGR2 AGR3 ASPH BTC C1QA C1QL4 C1QTNF5 C1QTNF6 C5orf46 CALR CCL3L3 CD200R1 CD3D CD68 CD79B CD99L2 CDH15 CDSN CMPK1 COL10A1 COL1A2 COLQ COMP CREB3L3 CSH1 CSH2 CTAG1A CTAG1B CYB5R1 DEFA6 DEXI DMKN ECM1 EFEMP2 EMCN ERP29 ETNK1 EVA1A FBN1 FGF21 FZD7 GALNT11 GGH GIP GPX7 GYPA HSP90B1 HSPA13 IL6R IL6ST ITPRIP ITPRIPL1 KCNE5 KRT1 LAMP3 LAT LCN2 LHB LMO2 MYDGF NAXD NME3 OSMR PAGE3 PDIA6 PGRMC1 PODXL PPIB PPIC PRAP1 PRB1 PRB3 PRB4 PRR4 PSORS1C2 RAI2 RCN1 RNASE10 RNF144A RNF144B RNF170 SDC4 SDF2L1 SELENOM SERPINE1 SERPINF1 SERPINI2 SGCA SGTA SHISA5 SIL1 SLPI SOD3 SPINK4 SPP1 SRGN SYT11 SYT4 TFF1 TMEM108 TMEM123 TMPO TMUB1 TNFRSF19 TNFSF13 TXNDC12 UBL4A UPK3A VEGFC VWC2 WFDC12 ZG16 ZG16B	7 interacting genes: APP BAG6 GAD2 SGTA SGTB UBQLN1 UBQLN2
Entrez ID		54557	93099
HPRD ID		18049	12387
Ensembl ID		ENSG00000197860	ENSG00000161249
Uniprot IDs		Q96EQ0	A3EZ84 C9IYI1 C9J186 C9JCN1 E9PAQ7 M0R0A5 M0R3F8 Q6E0U4
PDB IDs		Not available	4F20
GO Terms Enriched among Interactors		Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Protein Binding Collagen Trimer Endoplasmic Reticulum Chaperone Complex Endoplasmic Reticulum Extracellular Matrix Protein Folding Smooth Endoplasmic Reticulum Extracellular Matrix Structural Constituent Serine-type Endopeptidase Inhibitor Activity Sarcoplasmic Reticulum Lumen Extracellular Exosome Interleukin-6 Binding Interleukin-6 Receptor Activity Oncostatin-M Receptor Complex Melanosome Response To Bacterium Hormone Activity Interleukin-6 Receptor Complex Ciliary Neurotrophic Factor Receptor Complex Oncostatin-M Receptor Activity Positive Regulation Of Transport Memory Response To Endoplasmic Reticulum Stress Defense Response To Bacterium Ciliary Neurotrophic Factor Receptor Activity Interleukin-11 Receptor Activity Interleukin-11 Binding Oncostatin-M-mediated Signaling Pathway Regulation Of Smooth Muscle Cell-matrix Adhesion Regulation Of Immune System Process Sequestering Of Calcium Ion Biomineral Tissue Development Basement Membrane Ciliary Neurotrophic Factor-mediated Signaling Pathway ERAD Pathway Growth Factor Activity Golgi Lumen Positive Regulation Of Acute Inflammatory Response Ciliary Neurotrophic Factor Receptor Binding Response To Stress Regulation Of Cell-substrate Adhesion	Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of ERAD Pathway Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of ERAD Pathway Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Post-translational Protein Targeting To Endoplasmic Reticulum Membrane ERAD Pathway Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Proteolysis TRC Complex Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Polyubiquitin Modification-dependent Protein Binding Regulation Of Cellular Response To Stress Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Catabolic Process Response To Endoplasmic Reticulum Stress Protein Targeting To Membrane Positive Regulation Of Protein Metabolic Process Identical Protein Binding Tail-anchored Membrane Protein Insertion Into ER Membrane Proteasomal Protein Catabolic Process Molecular Adaptor Activity Protein Catabolic Process Establishment Of Protein Localization To Membrane Protein Targeting Protein Insertion Into ER Membrane Proteolysis Involved In Protein Catabolic Process Regulation Of Protein Metabolic Process Hsp70 Protein Binding Cytoplasmic Vesicle Establishment Of Protein Localization To Organelle Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Catabolic Process Protein Insertion Into Membrane Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Receptor Internalization Macromolecule Catabolic Process Negative Regulation Of Store-operated Calcium Channel Activity Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Autophagosome Autophagosome Assembly