SGTB and CMPK1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SGTB	CMPK1
Description		small glutamine rich tetratricopeptide repeat co-chaperone beta	cytidine/uridine monophosphate kinase 1
Image		No pdb structure
GO Annotations	Cellular Component	Membrane TRC Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Protein Binding Hsp70 Protein Binding Identical Protein Binding Protein-folding Chaperone Binding Molecular Adaptor Activity	Nucleotide Binding Nucleoside Diphosphate Kinase Activity Uridine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Phosphotransferase Activity, Phosphate Group As Acceptor Nucleobase-containing Compound Kinase Activity UMP Kinase Activity CMP Kinase Activity DCMP Kinase Activity Nucleoside Monophosphate Kinase Activity
	Biological Process	Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Protein Homooligomerization Protein Heterooligomerization	Nucleobase-containing Compound Metabolic Process 'de Novo' Pyrimidine Nucleobase Biosynthetic Process Pyrimidine Nucleotide Biosynthetic Process UMP Biosynthetic Process UDP Biosynthetic Process Pyrimidine Ribonucleotide Biosynthetic Process Nucleobase-containing Small Molecule Interconversion CDP Biosynthetic Process Nucleoside Monophosphate Phosphorylation Pyrimidine-containing Compound Biosynthetic Process
Pathways			Interconversion of nucleotide di- and triphosphates
Drugs			Gemcitabine Cytidine-5'-Monophosphate Uridine-5'-Diphosphate P1-(adenosine-5'-P5-(uridine-5')pentaphosphate Tetrafluoroaluminate Ion
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Intralaminar thalamic nuclei volume ( 34006833) Subcortical volume (MOSTest) ( 32665545)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Corneal curvature ( 24963161) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		116 interacting genes: ABCG4 ADAT2 ADIPOQ AGR2 AGR3 ASPH BTC C1QA C1QL4 C1QTNF5 C1QTNF6 C5orf46 CALR CCL3L3 CD200R1 CD3D CD68 CD79B CD99L2 CDH15 CDSN CMPK1 COL10A1 COL1A2 COLQ COMP CREB3L3 CSH1 CSH2 CTAG1A CTAG1B CYB5R1 DEFA6 DEXI DMKN ECM1 EFEMP2 EMCN ERP29 ETNK1 EVA1A FBN1 FGF21 FZD7 GALNT11 GGH GIP GPX7 GYPA HSP90B1 HSPA13 IL6R IL6ST ITPRIP ITPRIPL1 KCNE5 KRT1 LAMP3 LAT LCN2 LHB LMO2 MYDGF NAXD NME3 OSMR PAGE3 PDIA6 PGRMC1 PODXL PPIB PPIC PRAP1 PRB1 PRB3 PRB4 PRR4 PSORS1C2 RAI2 RCN1 RNASE10 RNF144A RNF144B RNF170 SDC4 SDF2L1 SELENOM SERPINE1 SERPINF1 SERPINI2 SGCA SGTA SHISA5 SIL1 SLPI SOD3 SPINK4 SPP1 SRGN SYT11 SYT4 TFF1 TMEM108 TMEM123 TMPO TMUB1 TNFRSF19 TNFSF13 TXNDC12 UBL4A UPK3A VEGFC VWC2 WFDC12 ZG16 ZG16B	5 interacting genes: BACE1 CDC42 CIDEB SGTB TMEM132D
Entrez ID		54557	51727
HPRD ID		18049	18258
Ensembl ID		ENSG00000197860	ENSG00000162368
Uniprot IDs		Q96EQ0	A0A494BXC7 P30085
PDB IDs			1TEV 7E9V
Enriched GO Terms of Interacting Partners?		Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Protein Binding Collagen Trimer Endoplasmic Reticulum Chaperone Complex Endoplasmic Reticulum Extracellular Matrix Protein Folding Smooth Endoplasmic Reticulum Extracellular Matrix Structural Constituent Serine-type Endopeptidase Inhibitor Activity Sarcoplasmic Reticulum Lumen Extracellular Exosome Interleukin-6 Binding Interleukin-6 Receptor Activity Oncostatin-M Receptor Complex Melanosome Response To Bacterium Hormone Activity Interleukin-6 Receptor Complex Ciliary Neurotrophic Factor Receptor Complex Oncostatin-M Receptor Activity Positive Regulation Of Transport Memory Response To Endoplasmic Reticulum Stress Defense Response To Bacterium Ciliary Neurotrophic Factor Receptor Activity Interleukin-11 Receptor Activity Interleukin-11 Binding Oncostatin-M-mediated Signaling Pathway Regulation Of Smooth Muscle Cell-matrix Adhesion Regulation Of Immune System Process Sequestering Of Calcium Ion Biomineral Tissue Development Basement Membrane Ciliary Neurotrophic Factor-mediated Signaling Pathway ERAD Pathway Growth Factor Activity Golgi Lumen Positive Regulation Of Acute Inflammatory Response Ciliary Neurotrophic Factor Receptor Binding Response To Stress Regulation Of Cell-substrate Adhesion	Leading Edge Membrane Positive Regulation Of Lamellipodium Organization Positive Regulation Of Pseudopodium Assembly Endothelin Receptor Signaling Pathway Thioesterase Binding Regulation Of Attachment Of Spindle Microtubules To Kinetochore Establishment Of Apical/basal Cell Polarity Nucleus Localization Positive Regulation Of Lamellipodium Assembly Heart Process Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Pinocytosis Dendritic Cell Migration Apolipoprotein A-I Receptor Binding Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Golgi Localization Establishment Of Monopolar Cell Polarity GTP-dependent Protein Binding Cellular Localization Heart Contraction Endothelin Receptor Signaling Pathway Involved In Heart Process Cardiac Conduction System Development Embryonic Heart Tube Development Establishment Of Epithelial Cell Polarity Neuron Fate Determination Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Dendritic Spine Morphogenesis Dendrite Positive Regulation Of Filopodium Assembly Establishment Of Golgi Localization Dendritic Spine Organization Phagocytosis, Engulfment Neuronal Cell Body Establishment Of Epithelial Cell Apical/basal Polarity Filopodium Assembly Establishment Or Maintenance Of Monopolar Cell Polarity Neuropilin Signaling Pathway GBD Domain Binding Golgi Transport Complex Storage Vacuole Identical Protein Binding Cell Migration Involved In Heart Development Polarized Epithelial Cell Differentiation Spindle Midzone Supramolecular Fiber Organization Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Nuclear Migration Positive Regulation Of Programmed Cell Death Prepulse Inhibition
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