PPIB and ATP12A

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		PPIB	ATP12A
Description		peptidylprolyl isomerase B	ATPase H+/K+ transporting non-gastric alpha2 subunit
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Smooth Endoplasmic Reticulum Cytosol Focal Adhesion Membrane Protein-containing Complex Endoplasmic Reticulum Chaperone Complex Melanosome Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Extracellular Exosome	Cytosol Plasma Membrane Potassium:proton Exchanging ATPase Complex Actin Cytoskeleton Membrane Basolateral Plasma Membrane Apical Plasma Membrane Cation-transporting ATPase Complex Plasma Membrane Protein Complex
	Molecular Function	RNA Binding Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Collagen Binding Cyclosporin A Binding Isomerase Activity Unfolded Protein Binding RNA Polymerase Binding	Nucleotide Binding P-type Sodium:potassium-exchanging Transporter Activity ATP Binding P-type Potassium Transmembrane Transporter Activity P-type Potassium:proton Transporter Activity ATP Hydrolysis Activity Metal Ion Binding
	Biological Process	Protein Folding Neutrophil Chemotaxis Positive Regulation Of Multicellular Organism Growth Host-mediated Activation Of Viral Process Host-mediated Activation Of Viral Genome Replication Protein Stabilization Bone Development Regulation Of Post-translational Protein Modification	Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Intracellular Sodium Ion Homeostasis Regulation Of PH Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Intracellular Potassium Ion Homeostasis Sodium Ion Export Across Plasma Membrane Potassium Ion Homeostasis Proton Transmembrane Transport Potassium Ion Import Across Plasma Membrane
Pathways		Collagen biosynthesis and modifying enzymes SARS-CoV-1 activates/modulates innate immune responses	Ion transport by P-type ATPases
Drugs		Proline 1,4-Dithiothreitol
Diseases		Osteogenesis imperfecta
GWAS			Diastolic blood pressure ( 30224653) Meconium ileus in cystic fibrosis ( 30807572) Obesity-related traits ( 23251661)
Interacting Genes		24 interacting genes: APOB ATP12A BANP CAMLG CEBPA DNM2 ESR1 GLP1R H3-4 HSPA6 IRF3 MDM2 PEX19 PRH1 PRL SGTA SGTB STAT5A TP53 TRDN UBQLN1 UBQLN2 UBQLN4 VKORC1	3 interacting genes: GNAI3 NPY PPIB
Entrez ID		5479	479
HPRD ID		00458	01667
Ensembl ID		ENSG00000166794	ENSG00000075673
Uniprot IDs		P23284	B4E0R9 P54707
PDB IDs		1CYN 3ICH 3ICI 8K0F 8K0I 8K0M 8K17 8KC9
Enriched GO Terms of Interacting Partners?		Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Identical Protein Binding TRC Complex Positive Regulation Of ERAD Pathway Regulation Of MiRNA Transcription Regulation Of Ubiquitin-dependent Protein Catabolic Process Cellular Response To Actinomycin D Regulation Of ERAD Pathway Protein-containing Complex Regulation Of MiRNA Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Response To Actinomycin D Cellular Response To UV-C Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Establishment Of Protein Localization Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Leukocyte Apoptotic Process Negative Regulation Of Proteolysis Autophagy Positive Regulation Of MiRNA Transcription Cellular Response To Antibiotic Regulation Of Cellular Response To Stress Response To Estrogen Positive Regulation Of MiRNA Metabolic Process Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Positive Regulation Of Macromolecule Metabolic Process Response To Stress Cardiac Septum Morphogenesis Regulation Of Macroautophagy Response To UV-C Establishment Of Protein Localization To Membrane Response To Hormone Autophagosome Tail-anchored Membrane Protein Insertion Into ER Membrane Cellular Response To Stress Enzyme Binding Myeloid Cell Apoptotic Process Cellular Response To Estrogen Stimulus Cytokine-mediated Signaling Pathway Regulation Of Response To Endoplasmic Reticulum Stress DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Response To Endoplasmic Reticulum Stress ERAD Pathway	G Protein-coupled Receptor Binding Negative Regulation Of Adenylate Cyclase Activity Neuropeptide Y Receptor Binding Monocyte Activation Positive Regulation Of Eating Behavior Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Regulation Of Eating Behavior Positive Regulation Of Response To Food Short-day Photoperiodism Regulation Of Nerve Growth Factor Production Positive Regulation Of Dopamine Metabolic Process Antifungal Humoral Response Positive Regulation Of Appetite Synaptic Signaling Via Neuropeptide Intestinal Epithelial Cell Differentiation Adult Feeding Behavior Positive Regulation Of Feeding Behavior Cyclosporin A Binding Endoplasmic Reticulum Chaperone Complex Host-mediated Perturbation Of Viral Genome Replication Host-mediated Activation Of Viral Genome Replication Negative Regulation Of Acute Inflammatory Response Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Response To Yeast Guanyl Nucleotide Binding Regulation Of Response To Food Regulation Of Acute Inflammatory Response To Antigenic Stimulus G-protein Beta/gamma-subunit Complex Binding GTP Metabolic Process Regulation Of Dopamine Metabolic Process Neuronal Dense Core Vesicle Smooth Endoplasmic Reticulum RNA Polymerase Binding Regulation Of Appetite Regulation Of Feeding Behavior Photoperiodism Perinuclear Region Of Cytoplasm Positive Regulation Of Behavior Neuropeptide Hormone Activity Negative Regulation Of Inflammatory Response To Antigenic Stimulus Heterotrimeric G-protein Complex Positive Regulation Of Multicellular Organism Growth G Protein-coupled Receptor Signaling Pathway Regulation Of Response To Nutrient Levels Peptidyl-prolyl Cis-trans Isomerase Activity Host-mediated Activation Of Viral Process Terminal Bouton Positive Regulation Of Nitric Oxide Metabolic Process Calcium Channel Regulator Activity Central Nervous System Neuron Development
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