SGTB and SIL1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SGTB	SIL1
Description		small glutamine rich tetratricopeptide repeat co-chaperone beta	SIL1 nucleotide exchange factor
Image		No pdb structure
GO Annotations	Cellular Component	Membrane TRC Complex	Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen
	Molecular Function	Protein Binding Hsp70 Protein Binding Identical Protein Binding Protein-folding Chaperone Binding Molecular Adaptor Activity	Adenyl-nucleotide Exchange Factor Activity Protein Binding Identical Protein Binding Unfolded Protein Binding
	Biological Process	Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Protein Homooligomerization Protein Heterooligomerization	Protein Folding Cotranslational Protein Targeting To Membrane Intracellular Protein Transport Protein Transport
Pathways
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Intralaminar thalamic nuclei volume ( 34006833) Subcortical volume (MOSTest) ( 32665545)	Appendicular lean mass ( 33097823) Malaria ( 31844061)
Interacting Genes		116 interacting genes: ABCG4 ADAT2 ADIPOQ AGR2 AGR3 ASPH BTC C1QA C1QL4 C1QTNF5 C1QTNF6 C5orf46 CALR CCL3L3 CD200R1 CD3D CD68 CD79B CD99L2 CDH15 CDSN CMPK1 COL10A1 COL1A2 COLQ COMP CREB3L3 CSH1 CSH2 CTAG1A CTAG1B CYB5R1 DEFA6 DEXI DMKN ECM1 EFEMP2 EMCN ERP29 ETNK1 EVA1A FBN1 FGF21 FZD7 GALNT11 GGH GIP GPX7 GYPA HSP90B1 HSPA13 IL6R IL6ST ITPRIP ITPRIPL1 KCNE5 KRT1 LAMP3 LAT LCN2 LHB LMO2 MYDGF NAXD NME3 OSMR PAGE3 PDIA6 PGRMC1 PODXL PPIB PPIC PRAP1 PRB1 PRB3 PRB4 PRR4 PSORS1C2 RAI2 RCN1 RNASE10 RNF144A RNF144B RNF170 SDC4 SDF2L1 SELENOM SERPINE1 SERPINF1 SERPINI2 SGCA SGTA SHISA5 SIL1 SLPI SOD3 SPINK4 SPP1 SRGN SYT11 SYT4 TFF1 TMEM108 TMEM123 TMPO TMUB1 TNFRSF19 TNFSF13 TXNDC12 UBL4A UPK3A VEGFC VWC2 WFDC12 ZG16 ZG16B	6 interacting genes: CCND3 FEM1C HSPA5 SGTB SMAD9 UBQLN1
Entrez ID		54557	64374
HPRD ID		18049	12150
Ensembl ID		ENSG00000197860	ENSG00000120725
Uniprot IDs		Q96EQ0	A0A0S2Z6B4 Q9H173
PDB IDs			6LBN 6LEY 8PQL 8Q7R
Enriched GO Terms of Interacting Partners?		Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Protein Binding Collagen Trimer Endoplasmic Reticulum Chaperone Complex Endoplasmic Reticulum Extracellular Matrix Protein Folding Smooth Endoplasmic Reticulum Extracellular Matrix Structural Constituent Serine-type Endopeptidase Inhibitor Activity Sarcoplasmic Reticulum Lumen Extracellular Exosome Interleukin-6 Binding Interleukin-6 Receptor Activity Oncostatin-M Receptor Complex Melanosome Response To Bacterium Hormone Activity Interleukin-6 Receptor Complex Ciliary Neurotrophic Factor Receptor Complex Oncostatin-M Receptor Activity Positive Regulation Of Transport Memory Response To Endoplasmic Reticulum Stress Defense Response To Bacterium Ciliary Neurotrophic Factor Receptor Activity Interleukin-11 Receptor Activity Interleukin-11 Binding Oncostatin-M-mediated Signaling Pathway Regulation Of Smooth Muscle Cell-matrix Adhesion Regulation Of Immune System Process Sequestering Of Calcium Ion Biomineral Tissue Development Basement Membrane Ciliary Neurotrophic Factor-mediated Signaling Pathway ERAD Pathway Growth Factor Activity Golgi Lumen Positive Regulation Of Acute Inflammatory Response Ciliary Neurotrophic Factor Receptor Binding Response To Stress Regulation Of Cell-substrate Adhesion	Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Ubiquitination Regulation Of Cellular Response To Stress Regulation Of Protein Ubiquitination Regulation Of Post-translational Protein Modification Regulation Of Protein Folding In Endoplasmic Reticulum Regulation Of MRNA Stability Involved In Cellular Response To UV Regulation Of EIF2 Alpha Phosphorylation By DsRNA Negative Regulation Of Store-operated Calcium Channel Activity Ghrelin Receptor Binding Cortisol Secretion Positive Regulation Of Gastric Mucosal Blood Circulation FMN Biosynthetic Process Positive Regulation Of NAD(P)H Oxidase Activity Riboflavin Kinase Activity Riboflavin Biosynthetic Process Cyclin D3-CDK6 Complex Cyclin D3-CDK4 Complex Cerebellum Structural Organization Regulation Of Endoribonuclease Activity Growth Hormone-releasing Hormone Activity Negative Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Small Intestinal Transit Positive Regulation Of Growth Rate TRC Complex Flavin Adenine Dinucleotide Biosynthetic Process Protein-folding Chaperone Binding Positive Regulation Of Protein Modification Process Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Synapse Assembly Positive Regulation Of Small Intestine Smooth Muscle Contraction Positive Regulation Of Bone Development Positive Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Cell Cycle Phase Transition Unfolded Protein Binding Regulation Of ATF6-mediated Unfolded Protein Response Positive Regulation Of Eating Behavior Positive Regulation Of Cortisol Secretion Positive Regulation Of Response To Food Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Appetite Regulation Of Gastric Motility Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Riboflavin Metabolic Process Proteasomal Protein Catabolic Process Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Regulation Of Ribonuclease Activity
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