PPIB and HSPA6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PPIB	HSPA6
Description		peptidylprolyl isomerase B	heat shock protein family A (Hsp70) member 6
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Smooth Endoplasmic Reticulum Cytosol Focal Adhesion Membrane Protein-containing Complex Endoplasmic Reticulum Chaperone Complex Melanosome Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Extracellular Exosome	Extracellular Region Nucleus Cytoplasm Centriole Cytosol Plasma Membrane COP9 Signalosome Secretory Granule Lumen Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen
	Molecular Function	RNA Binding Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Collagen Binding Cyclosporin A Binding Isomerase Activity Unfolded Protein Binding RNA Polymerase Binding	Nucleotide Binding Protein Binding ATP Binding ATP Hydrolysis Activity Enzyme Binding Heat Shock Protein Binding Protein Folding Chaperone Unfolded Protein Binding ATP-dependent Protein Folding Chaperone
	Biological Process	Protein Folding Neutrophil Chemotaxis Positive Regulation Of Multicellular Organism Growth Host-mediated Activation Of Viral Process Host-mediated Activation Of Viral Genome Replication Protein Stabilization Bone Development Regulation Of Post-translational Protein Modification	Protein Folding Response To Unfolded Protein Cellular Response To Heat Protein Refolding Cellular Heat Acclimation
Pathways		Collagen biosynthesis and modifying enzymes SARS-CoV-1 activates/modulates innate immune responses	Regulation of HSF1-mediated heat shock response Neutrophil degranulation
Drugs		Proline 1,4-Dithiothreitol
Diseases		Osteogenesis imperfecta
GWAS			Alanine aminotransferase levels ( 33547301) Birth weight ( 31043758) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Functional impairment in major depressive disorder, bipolar disorder and schizophrenia ( 24039173) Helicobacter pylori serologic status ( 23652523) Inflammatory bowel disease ( 23128233 28067908) Offspring birth weight ( 31043758) Ulcerative colitis ( 21297633 28067908)
Interacting Genes		24 interacting genes: APOB ATP12A BANP CAMLG CEBPA DNM2 ESR1 GLP1R H3-4 HSPA6 IRF3 MDM2 PEX19 PRH1 PRL SGTA SGTB STAT5A TP53 TRDN UBQLN1 UBQLN2 UBQLN4 VKORC1	18 interacting genes: ADCK5 AHCYL1 BAG4 C22orf15 CISH COMMD6 CYP4F12 DNAJB4 FLNA KRT222 LGALS7 LGALS7B PPIB PRAP1 RPA1 SNCA TERF1 WEE2-AS1
Entrez ID		5479	3310
HPRD ID		00458	00775
Ensembl ID		ENSG00000166794	ENSG00000173110
Uniprot IDs		P23284	A0A384NKX5 B3KSM6 P17066
PDB IDs		1CYN 3ICH 3ICI 8K0F 8K0I 8K0M 8K17 8KC9	3FE1
Enriched GO Terms of Interacting Partners?		Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Identical Protein Binding TRC Complex Positive Regulation Of ERAD Pathway Regulation Of MiRNA Transcription Regulation Of Ubiquitin-dependent Protein Catabolic Process Cellular Response To Actinomycin D Regulation Of ERAD Pathway Protein-containing Complex Regulation Of MiRNA Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Response To Actinomycin D Cellular Response To UV-C Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Establishment Of Protein Localization Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Leukocyte Apoptotic Process Negative Regulation Of Proteolysis Autophagy Positive Regulation Of MiRNA Transcription Cellular Response To Antibiotic Regulation Of Cellular Response To Stress Response To Estrogen Positive Regulation Of MiRNA Metabolic Process Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Positive Regulation Of Macromolecule Metabolic Process Response To Stress Cardiac Septum Morphogenesis Regulation Of Macroautophagy Response To UV-C Establishment Of Protein Localization To Membrane Response To Hormone Autophagosome Tail-anchored Membrane Protein Insertion Into ER Membrane Cellular Response To Stress Enzyme Binding Myeloid Cell Apoptotic Process Cellular Response To Estrogen Stimulus Cytokine-mediated Signaling Pathway Regulation Of Response To Endoplasmic Reticulum Stress DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Response To Endoplasmic Reticulum Stress ERAD Pathway	Regulation Of B Cell Antigen Processing And Presentation Negative Regulation Of Exocytosis Immune Complex Clearance By Monocytes And Macrophages Negative Regulation Of Type I Hypersensitivity Negative Regulation Of Antibody-dependent Cellular Cytotoxicity Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Regulation Of Protein Stability Positive Regulation Of Organelle Organization Protein Sequestering Activity Intracellular Membrane-bounded Organelle Telomere Maintenance Via Telomere Lengthening RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomerase G-rich Strand Telomeric DNA Binding Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Negative Regulation Of MRNA Modification Positive Regulation Of Triglyceride Transport Positive Regulation Of Monoatomic Ion Transport Positive Regulation Of Cellular Component Organization
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