SGTB and TNFRSF19

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SGTB	TNFRSF19
Description		small glutamine rich tetratricopeptide repeat co-chaperone beta	TNF receptor superfamily member 19
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Membrane TRC Complex	Plasma Membrane Membrane
	Molecular Function	Protein Binding Hsp70 Protein Binding Identical Protein Binding Protein-folding Chaperone Binding Molecular Adaptor Activity	Tumor Necrosis Factor Receptor Activity Protein Binding Signaling Receptor Activity
	Biological Process	Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Protein Homooligomerization Protein Heterooligomerization	Hair Follicle Development Apoptotic Process JNK Cascade Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of JNK Cascade
Pathways
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Intralaminar thalamic nuclei volume ( 34006833) Subcortical volume (MOSTest) ( 32665545)	Blood pressure (smoking interaction) ( 25189868) Blood protein levels ( 30072576) Diabetic kidney disease ( 26305897) Heel bone mineral density ( 30598549) Hypothyroidism ( 22493691) Nasopharyngeal carcinoma ( 20512145 26545403) Visceral adipose tissue adjusted for BMI ( 22589738)
Interacting Genes		116 interacting genes: ABCG4 ADAT2 ADIPOQ AGR2 AGR3 ASPH BTC C1QA C1QL4 C1QTNF5 C1QTNF6 C5orf46 CALR CCL3L3 CD200R1 CD3D CD68 CD79B CD99L2 CDH15 CDSN CMPK1 COL10A1 COL1A2 COLQ COMP CREB3L3 CSH1 CSH2 CTAG1A CTAG1B CYB5R1 DEFA6 DEXI DMKN ECM1 EFEMP2 EMCN ERP29 ETNK1 EVA1A FBN1 FGF21 FZD7 GALNT11 GGH GIP GPX7 GYPA HSP90B1 HSPA13 IL6R IL6ST ITPRIP ITPRIPL1 KCNE5 KRT1 LAMP3 LAT LCN2 LHB LMO2 MYDGF NAXD NME3 OSMR PAGE3 PDIA6 PGRMC1 PODXL PPIB PPIC PRAP1 PRB1 PRB3 PRB4 PRR4 PSORS1C2 RAI2 RCN1 RNASE10 RNF144A RNF144B RNF170 SDC4 SDF2L1 SELENOM SERPINE1 SERPINF1 SERPINI2 SGCA SGTA SHISA5 SIL1 SLPI SOD3 SPINK4 SPP1 SRGN SYT11 SYT4 TFF1 TMEM108 TMEM123 TMPO TMUB1 TNFRSF19 TNFSF13 TXNDC12 UBL4A UPK3A VEGFC VWC2 WFDC12 ZG16 ZG16B	9 interacting genes: GIMAP5 MTURN SGTA SGTB TRAF1 TRAF2 TRAF3 TRAF5 TRAF6
Entrez ID		54557	55504
HPRD ID		18049	05838
Ensembl ID		ENSG00000197860	ENSG00000127863
Uniprot IDs		Q96EQ0	Q9NS68
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Protein Binding Collagen Trimer Endoplasmic Reticulum Chaperone Complex Endoplasmic Reticulum Extracellular Matrix Protein Folding Smooth Endoplasmic Reticulum Extracellular Matrix Structural Constituent Serine-type Endopeptidase Inhibitor Activity Sarcoplasmic Reticulum Lumen Extracellular Exosome Interleukin-6 Binding Interleukin-6 Receptor Activity Oncostatin-M Receptor Complex Melanosome Response To Bacterium Hormone Activity Interleukin-6 Receptor Complex Ciliary Neurotrophic Factor Receptor Complex Oncostatin-M Receptor Activity Positive Regulation Of Transport Memory Response To Endoplasmic Reticulum Stress Defense Response To Bacterium Ciliary Neurotrophic Factor Receptor Activity Interleukin-11 Receptor Activity Interleukin-11 Binding Oncostatin-M-mediated Signaling Pathway Regulation Of Smooth Muscle Cell-matrix Adhesion Regulation Of Immune System Process Sequestering Of Calcium Ion Biomineral Tissue Development Basement Membrane Ciliary Neurotrophic Factor-mediated Signaling Pathway ERAD Pathway Growth Factor Activity Golgi Lumen Positive Regulation Of Acute Inflammatory Response Ciliary Neurotrophic Factor Receptor Binding Response To Stress Regulation Of Cell-substrate Adhesion	Tumor Necrosis Factor Receptor Binding Thioesterase Binding CD40 Receptor Complex Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Signaling Adaptor Activity CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity TRC Complex Cytoplasmic Side Of Plasma Membrane Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Canonical NF-kappaB Signal Transduction Cytokine-mediated Signaling Pathway Identical Protein Binding Post-translational Protein Targeting To Endoplasmic Reticulum Membrane TRIF-dependent Toll-like Receptor Signaling Pathway Ubiquitin Protein Ligase Binding Positive Regulation Of JUN Kinase Activity MyD88-independent Toll-like Receptor Signaling Pathway Ubiquitin Protein Ligase Activity Regulation Of JNK Cascade Protein Targeting To ER Positive Regulation Of T Cell Cytokine Production Non-canonical NF-kappaB Signal Transduction Establishment Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of MAP Kinase Activity Positive Regulation Of Interleukin-2 Production Signal Transduction Involved In Regulation Of Gene Expression Regulation Of T Cell Cytokine Production Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Canonical NF-kappaB Signal Transduction Toll-like Receptor 4 Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Ubiquitin-protein Transferase Activity Toll-like Receptor Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Endosome Membrane MRNA Transcription TORC2 Complex Disassembly Regulation Of Interleukin-2 Production Negative Regulation Of DNA-binding Transcription Factor Activity Regulation Of MAP Kinase Activity MRNA Stabilization Regulation Of Apoptotic Process
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