SGTB and ITPRIPL1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SGTB	ITPRIPL1
Description		small glutamine rich tetratricopeptide repeat co-chaperone beta	ITPRIP like 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Membrane TRC Complex	Plasma Membrane Membrane
	Molecular Function	Protein Binding Hsp70 Protein Binding Identical Protein Binding Protein-folding Chaperone Binding Molecular Adaptor Activity	Protein Binding Receptor Ligand Activity
	Biological Process	Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Protein Homooligomerization Protein Heterooligomerization	Signal Transduction Negative Regulation Of Signal Transduction T Cell Differentiation T Cell Activation Positive Regulation Of MAPK Cascade T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Calcium Ion Import
Pathways
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Intralaminar thalamic nuclei volume ( 34006833) Subcortical volume (MOSTest) ( 32665545)	Major depressive disorder ( 29317602)
Interacting Genes		116 interacting genes: ABCG4 ADAT2 ADIPOQ AGR2 AGR3 ASPH BTC C1QA C1QL4 C1QTNF5 C1QTNF6 C5orf46 CALR CCL3L3 CD200R1 CD3D CD68 CD79B CD99L2 CDH15 CDSN CMPK1 COL10A1 COL1A2 COLQ COMP CREB3L3 CSH1 CSH2 CTAG1A CTAG1B CYB5R1 DEFA6 DEXI DMKN ECM1 EFEMP2 EMCN ERP29 ETNK1 EVA1A FBN1 FGF21 FZD7 GALNT11 GGH GIP GPX7 GYPA HSP90B1 HSPA13 IL6R IL6ST ITPRIP ITPRIPL1 KCNE5 KRT1 LAMP3 LAT LCN2 LHB LMO2 MYDGF NAXD NME3 OSMR PAGE3 PDIA6 PGRMC1 PODXL PPIB PPIC PRAP1 PRB1 PRB3 PRB4 PRR4 PSORS1C2 RAI2 RCN1 RNASE10 RNF144A RNF144B RNF170 SDC4 SDF2L1 SELENOM SERPINE1 SERPINF1 SERPINI2 SGCA SGTA SHISA5 SIL1 SLPI SOD3 SPINK4 SPP1 SRGN SYT11 SYT4 TFF1 TMEM108 TMEM123 TMPO TMUB1 TNFRSF19 TNFSF13 TXNDC12 UBL4A UPK3A VEGFC VWC2 WFDC12 ZG16 ZG16B	7 interacting genes: CDSN SGTA SGTB TRAF2 UBQLN1 UBQLN2 UBQLN4
Entrez ID		54557	150771
HPRD ID		18049	13893
Ensembl ID		ENSG00000197860	ENSG00000198885
Uniprot IDs		Q96EQ0	Q6GPH6
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Protein Binding Collagen Trimer Endoplasmic Reticulum Chaperone Complex Endoplasmic Reticulum Extracellular Matrix Protein Folding Smooth Endoplasmic Reticulum Extracellular Matrix Structural Constituent Serine-type Endopeptidase Inhibitor Activity Sarcoplasmic Reticulum Lumen Extracellular Exosome Interleukin-6 Binding Interleukin-6 Receptor Activity Oncostatin-M Receptor Complex Melanosome Response To Bacterium Hormone Activity Interleukin-6 Receptor Complex Ciliary Neurotrophic Factor Receptor Complex Oncostatin-M Receptor Activity Positive Regulation Of Transport Memory Response To Endoplasmic Reticulum Stress Defense Response To Bacterium Ciliary Neurotrophic Factor Receptor Activity Interleukin-11 Receptor Activity Interleukin-11 Binding Oncostatin-M-mediated Signaling Pathway Regulation Of Smooth Muscle Cell-matrix Adhesion Regulation Of Immune System Process Sequestering Of Calcium Ion Biomineral Tissue Development Basement Membrane Ciliary Neurotrophic Factor-mediated Signaling Pathway ERAD Pathway Growth Factor Activity Golgi Lumen Positive Regulation Of Acute Inflammatory Response Ciliary Neurotrophic Factor Receptor Binding Response To Stress Regulation Of Cell-substrate Adhesion	Positive Regulation Of ERAD Pathway TRC Complex Regulation Of ERAD Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Polyubiquitin Modification-dependent Protein Binding Regulation Of Proteasomal Protein Catabolic Process Response To Endoplasmic Reticulum Stress Autophagosome Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Regulation Of Protein Catabolic Process Regulation Of Proteolysis Identical Protein Binding Positive Regulation Of Proteasomal Protein Catabolic Process Macromolecule Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Cellular Response To Stress Regulation Of Macroautophagy Positive Regulation Of Proteolysis Protein Catabolic Process Protein Targeting To ER Positive Regulation Of Protein Catabolic Process Establishment Of Protein Localization To Endoplasmic Reticulum Proteolysis Involved In Protein Catabolic Process Regulation Of Protein Metabolic Process Cellular Response To Stress Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Autophagy Catabolic Process Protein Targeting To Membrane Regulation Of Autophagy Negative Regulation Of Catabolic Process Negative Regulation Of Cornification TORC2 Complex Disassembly Negative Regulation Of Store-operated Calcium Channel Activity Autophagosome Assembly Proteolysis Proteasomal Protein Catabolic Process Corneocyte Desquamation TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Autophagosome Organization Negative Regulation Of G Protein-coupled Receptor Internalization Nuclear Proteasome Complex Positive Regulation Of Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process
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