SGTB and IL6R

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SGTB	IL6R
Description		small glutamine rich tetratricopeptide repeat co-chaperone beta	interleukin 6 receptor
Image		No pdb structure
GO Annotations	Cellular Component	Membrane TRC Complex	Extracellular Region Extracellular Space Plasma Membrane Interleukin-6 Receptor Complex External Side Of Plasma Membrane Membrane Apical Plasma Membrane Receptor Complex Ciliary Neurotrophic Factor Receptor Complex
	Molecular Function	Protein Binding Hsp70 Protein Binding Identical Protein Binding Protein-folding Chaperone Binding Molecular Adaptor Activity	Cytokine Receptor Activity Ciliary Neurotrophic Factor Receptor Activity Interleukin-6 Receptor Activity Interleukin-11 Receptor Activity Interleukin-6 Receptor Binding Protein Binding Enzyme Binding Interleukin-11 Binding Interleukin-6 Binding Protein Homodimerization Activity Ciliary Neurotrophic Factor Binding
	Biological Process	Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Protein Homooligomerization Protein Heterooligomerization	Hepatic Immune Response Neutrophil Mediated Immunity Monocyte Chemotaxis Positive Regulation Of Leukocyte Chemotaxis Acute-phase Response Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Population Proliferation Vascular Endothelial Growth Factor Production Cytokine-mediated Signaling Pathway Endocrine Pancreas Development Developmental Process Negative Regulation Of Interleukin-8 Production Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Negative Regulation Of Collagen Biosynthetic Process Response To Cytokine Interleukin-11-mediated Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Smooth Muscle Cell Proliferation Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Interleukin-6-mediated Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway Positive Regulation Of Glomerular Mesangial Cell Proliferation T-helper 17 Cell Lineage Commitment Extrinsic Apoptotic Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Positive Regulation Of Platelet Aggregation
Pathways			Interleukin-6 signaling MAPK3 (ERK1) activation MAPK1 (ERK2) activation Interleukin-4 and Interleukin-13 signaling Transcriptional regulation of granulopoiesis Potential therapeutics for SARS
Drugs			Tocilizumab Sarilumab Satralizumab
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Intralaminar thalamic nuclei volume ( 34006833) Subcortical volume (MOSTest) ( 32665545)	Abdominal aortic aneurysm ( 27899403) Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever or eczema) ( 29083406) Ankylosing spondylitis ( 23749187) Asthma ( 32296059 21907864) Atopic dermatitis ( 26482879) Atrial fibrillation ( 29892015) Blood protein levels ( 30072576 23696881) Blood protein levels in cardiovascular risk ( 28369058) C-reactive protein ( 19567438 18439548) C-reactive protein levels ( 30388399 29878111 29403010 21300955 33339817) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Coronary artery disease ( 26343387 32469254 29212778 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Fibrinogen ( 20031577 23969696) Fibrinogen levels ( 28107422 26561523) Interleukin-6 levels ( 33517400 32473944) Interleukin-6 levels in HIV infection ( 33095540) Iron status biomarkers (iron levels) ( 33536631) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Liver enzyme levels (alkaline phosphatase) ( 33972514) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 27863252 32888494) Mosquito bite size ( 28199695) Myocardial infarction ( 26343387 33532862) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Platelet count ( 32888494) Protein quantitative trait loci ( 18464913) Pulmonary function ( 17903307) Red cell distribution width ( 32888494) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy) ( 24554482) Rheumatoid arthritis ( 24390342 23143596 30423114) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Serum alkaline phosphatase levels ( 33547301) Systemic lupus erythematosus ( 28714469) Type 1 diabetes ( 34127860)
Interacting Genes		116 interacting genes: ABCG4 ADAT2 ADIPOQ AGR2 AGR3 ASPH BTC C1QA C1QL4 C1QTNF5 C1QTNF6 C5orf46 CALR CCL3L3 CD200R1 CD3D CD68 CD79B CD99L2 CDH15 CDSN CMPK1 COL10A1 COL1A2 COLQ COMP CREB3L3 CSH1 CSH2 CTAG1A CTAG1B CYB5R1 DEFA6 DEXI DMKN ECM1 EFEMP2 EMCN ERP29 ETNK1 EVA1A FBN1 FGF21 FZD7 GALNT11 GGH GIP GPX7 GYPA HSP90B1 HSPA13 IL6R IL6ST ITPRIP ITPRIPL1 KCNE5 KRT1 LAMP3 LAT LCN2 LHB LMO2 MYDGF NAXD NME3 OSMR PAGE3 PDIA6 PGRMC1 PODXL PPIB PPIC PRAP1 PRB1 PRB3 PRB4 PRR4 PSORS1C2 RAI2 RCN1 RNASE10 RNF144A RNF144B RNF170 SDC4 SDF2L1 SELENOM SERPINE1 SERPINF1 SERPINI2 SGCA SGTA SHISA5 SIL1 SLPI SOD3 SPINK4 SPP1 SRGN SYT11 SYT4 TFF1 TMEM108 TMEM123 TMPO TMUB1 TNFRSF19 TNFSF13 TXNDC12 UBL4A UPK3A VEGFC VWC2 WFDC12 ZG16 ZG16B	11 interacting genes: ADRB2 CNTF ERAP1 IL6 IL6ST MAGI1 SGTB SRC STAT3 WWP1 WWP2
Entrez ID		54557	3570
HPRD ID		18049	01000
Ensembl ID		ENSG00000197860	ENSG00000160712
Uniprot IDs		Q96EQ0	A0A087WTB5 A0N0L5 P08887
PDB IDs			1N26 1P9M 2ARW 5FUC 7DC8 8D82 8IOW 8QY5 8QY6
Enriched GO Terms of Interacting Partners?		Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Protein Binding Collagen Trimer Endoplasmic Reticulum Chaperone Complex Endoplasmic Reticulum Extracellular Matrix Protein Folding Smooth Endoplasmic Reticulum Extracellular Matrix Structural Constituent Serine-type Endopeptidase Inhibitor Activity Sarcoplasmic Reticulum Lumen Extracellular Exosome Interleukin-6 Binding Interleukin-6 Receptor Activity Oncostatin-M Receptor Complex Melanosome Response To Bacterium Hormone Activity Interleukin-6 Receptor Complex Ciliary Neurotrophic Factor Receptor Complex Oncostatin-M Receptor Activity Positive Regulation Of Transport Memory Response To Endoplasmic Reticulum Stress Defense Response To Bacterium Ciliary Neurotrophic Factor Receptor Activity Interleukin-11 Receptor Activity Interleukin-11 Binding Oncostatin-M-mediated Signaling Pathway Regulation Of Smooth Muscle Cell-matrix Adhesion Regulation Of Immune System Process Sequestering Of Calcium Ion Biomineral Tissue Development Basement Membrane Ciliary Neurotrophic Factor-mediated Signaling Pathway ERAD Pathway Growth Factor Activity Golgi Lumen Positive Regulation Of Acute Inflammatory Response Ciliary Neurotrophic Factor Receptor Binding Response To Stress Regulation Of Cell-substrate Adhesion	Interleukin-6 Receptor Binding Interleukin-6-mediated Signaling Pathway T-helper 17 Cell Lineage Commitment Cell Surface Receptor Signaling Pathway Via JAK-STAT T-helper Cell Lineage Commitment Cell Surface Receptor Signaling Pathway Via STAT CD4-positive, Alpha-beta T Cell Lineage Commitment Alpha-beta T Cell Lineage Commitment CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Regulation Of Notch Signaling Pathway Negative Regulation Of Primary MiRNA Processing T Cell Lineage Commitment Positive Regulation Of Vascular Endothelial Growth Factor Production Interleukin-6 Receptor Complex Cell Differentiation Ciliary Neurotrophic Factor-mediated Signaling Pathway Positive Regulation Of Notch Signaling Pathway Regulation Of Vascular Endothelial Growth Factor Production Ciliary Neurotrophic Factor Receptor Binding Interleukin-11-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Negative Regulation Of MiRNA Processing Cellular Developmental Process Retinal Rod Cell Differentiation Positive Regulation Of Extracellular Matrix Disassembly Intestinal Epithelial Cell Development Inflammatory Response To Wounding Positive Regulation Of Platelet Aggregation Positive Regulation Of Developmental Process Regulation Of MiRNA Processing Developmental Process Camera-type Eye Photoreceptor Cell Differentiation Negative Regulation Of MiRNA-mediated Gene Silencing Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Regulation Of Regulatory NcRNA Processing Protein Tyrosine Kinase Activator Activity Columnar/cuboidal Epithelial Cell Development Negative Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Eye Photoreceptor Cell Differentiation Positive Regulation Of Homotypic Cell-cell Adhesion Negative Regulation Of Anoikis Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Phosphate Metabolic Process Photoreceptor Cell Differentiation Symbiont Entry Into Host Cell Positive Regulation Of Cell-cell Adhesion Regulation Of Extracellular Matrix Disassembly Bone Resorption
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