PPIB and TRDN

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PPIB	TRDN
Description		peptidylprolyl isomerase B	triadin
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Smooth Endoplasmic Reticulum Cytosol Focal Adhesion Membrane Protein-containing Complex Endoplasmic Reticulum Chaperone Complex Melanosome Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Extracellular Exosome	Nucleoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Junctional Sarcoplasmic Reticulum Membrane Membrane Sarcoplasmic Reticulum Junctional Membrane Complex Sarcoplasmic Reticulum Membrane Sarcoplasmic Reticulum Lumen
	Molecular Function	RNA Binding Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Collagen Binding Cyclosporin A Binding Isomerase Activity Unfolded Protein Binding RNA Polymerase Binding	Signaling Receptor Binding Protein Binding Protein-macromolecule Adaptor Activity Transmembrane Transporter Binding
	Biological Process	Protein Folding Neutrophil Chemotaxis Positive Regulation Of Multicellular Organism Growth Host-mediated Activation Of Viral Process Host-mediated Activation Of Viral Genome Replication Protein Stabilization Bone Development Regulation Of Post-translational Protein Modification	Intracellular Calcium Ion Homeostasis Muscle Contraction Response To Bacterium Regulation Of Cell Communication By Electrical Coupling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Cytoplasmic Microtubule Organization Regulation Of Sequestering Of Calcium Ion Establishment Of Localization In Cell Heart Contraction Regulation Of Cardiac Muscle Cell Membrane Potential Endoplasmic Reticulum Membrane Organization Positive Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction
Pathways		Collagen biosynthesis and modifying enzymes SARS-CoV-1 activates/modulates innate immune responses	Stimuli-sensing channels Ion homeostasis
Drugs		Proline 1,4-Dithiothreitol
Diseases		Osteogenesis imperfecta
GWAS			Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Borderline personality disorder ( 28632202) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) Intraocular pressure ( 30591961) Metabolite levels ( 23823483) Nickel levels ( 26025379) Night sleep phenotypes ( 27126917) Post bronchodilator FEV1 ( 26634245)
Interacting Genes		24 interacting genes: APOB ATP12A BANP CAMLG CEBPA DNM2 ESR1 GLP1R H3-4 HSPA6 IRF3 MDM2 PEX19 PRH1 PRL SGTA SGTB STAT5A TP53 TRDN UBQLN1 UBQLN2 UBQLN4 VKORC1	10 interacting genes: ASPH CALM1 CASQ1 CASQ2 HRC KCNE4 PPIB PTPRN RYR1 SOCS3
Entrez ID		5479	10345
HPRD ID		00458	04474
Ensembl ID		ENSG00000166794	ENSG00000186439
Uniprot IDs		P23284	A0A590UJV0 H9ME53 Q13061 Q8IVK2
PDB IDs		1CYN 3ICH 3ICI 8K0F 8K0I 8K0M 8K17 8KC9
Enriched GO Terms of Interacting Partners?		Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Identical Protein Binding TRC Complex Positive Regulation Of ERAD Pathway Regulation Of MiRNA Transcription Regulation Of Ubiquitin-dependent Protein Catabolic Process Cellular Response To Actinomycin D Regulation Of ERAD Pathway Protein-containing Complex Regulation Of MiRNA Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Response To Actinomycin D Cellular Response To UV-C Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Establishment Of Protein Localization Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Leukocyte Apoptotic Process Negative Regulation Of Proteolysis Autophagy Positive Regulation Of MiRNA Transcription Cellular Response To Antibiotic Regulation Of Cellular Response To Stress Response To Estrogen Positive Regulation Of MiRNA Metabolic Process Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Positive Regulation Of Macromolecule Metabolic Process Response To Stress Cardiac Septum Morphogenesis Regulation Of Macroautophagy Response To UV-C Establishment Of Protein Localization To Membrane Response To Hormone Autophagosome Tail-anchored Membrane Protein Insertion Into ER Membrane Cellular Response To Stress Enzyme Binding Myeloid Cell Apoptotic Process Cellular Response To Estrogen Stimulus Cytokine-mediated Signaling Pathway Regulation Of Response To Endoplasmic Reticulum Stress DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Response To Endoplasmic Reticulum Stress ERAD Pathway	Sarcoplasmic Reticulum Lumen Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Sequestering Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling Calcium-mediated Signaling Sarcoplasmic Reticulum Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Calcium Channel Complex Regulation Of Striated Muscle Contraction Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Sarcoplasmic Reticulum Membrane Regulation Of Calcium Ion Transmembrane Transport Junctional Sarcoplasmic Reticulum Membrane Regulation Of Muscle Contraction Regulation Of Heart Contraction Detection Of Calcium Ion Regulation Of Calcium Ion Transport Regulation Of Cardiac Muscle Contraction Regulation Of Muscle System Process Regulation Of Blood Circulation Smooth Endoplasmic Reticulum Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of System Process Regulation Of Heart Rate Regulation Of Monoatomic Ion Transmembrane Transport Calcium Ion Binding Regulation Of Metal Ion Transport Response To Calcium Ion Z Disc Transmembrane Transporter Binding Regulation Of Monoatomic Ion Transport Terminal Cisterna Intracellular Signaling Cassette Intracellular Calcium Ion Homeostasis Muscle Contraction Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Store-operated Calcium Channel Activity Calcium Ion Homeostasis Muscle System Process Intracellular Signal Transduction Regulation Of Monoatomic Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Cellular Response To Caffeine Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Cellular Response To Purine-containing Compound Response To Metal Ion Response To Caffeine Detection Of Chemical Stimulus Intracellular Monoatomic Cation Homeostasis
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