PPIB and STAT5A

Number of citations of the paper that reports this interaction (PMID 11997457)
28

Data Source:
HPRD (in vitro, in vivo)

		PPIB	STAT5A
Gene Name		peptidylprolyl isomerase B (cyclophilin B)	signal transducer and activator of transcription 5A
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Lumen Smooth Endoplasmic Reticulum Focal Adhesion Membrane Macromolecular Complex Melanosome Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Nucleoplasm Cytosol
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Collagen Binding Protein Complex Binding Peptide Binding Poly(A) RNA Binding Unfolded Protein Binding RNA Polymerase Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Protein Binding
	Biological Process	Protein Peptidyl-prolyl Isomerization Extracellular Matrix Organization Positive Regulation Of Multicellular Organism Growth Positive Regulation By Host Of Viral Process Positive Regulation By Host Of Viral Genome Replication Protein Stabilization Bone Development Chaperone-mediated Protein Folding Regulation Of Post-translational Protein Modification	Allantoin Metabolic Process Luteinization Natural Killer Cell Differentiation Citrate Metabolic Process 2-oxoglutarate Metabolic Process Succinate Metabolic Process Oxaloacetate Metabolic Process Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Isoleucine Metabolic Process Valine Metabolic Process Creatine Metabolic Process Fatty Acid Metabolic Process JAK-STAT Cascade Female Pregnancy Lactation Peptidyl-tyrosine Phosphorylation Regulation Of Steroid Metabolic Process Taurine Metabolic Process Lipid Storage Regulation Of Epithelial Cell Differentiation Positive Regulation Of Natural Killer Cell Differentiation Negative Regulation Of Mast Cell Apoptotic Process T Cell Differentiation In Thymus Prolactin Signaling Pathway Regulation Of Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Activated T Cell Proliferation T Cell Homeostasis Positive Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of B Cell Differentiation Positive Regulation Of Gamma-delta T Cell Differentiation Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Creatinine Metabolic Process Development Of Secondary Female Sexual Characteristics Development Of Secondary Male Sexual Characteristics Peyer's Patch Development Positive Regulation Of Inflammatory Response Positive Regulation Of Mast Cell Differentiation JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Prostate Gland Epithelium Morphogenesis Epithelial Cell Differentiation Involved In Prostate Gland Development Mammary Gland Epithelium Development Positive Regulation Of Mast Cell Proliferation Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus
Pathways		Collagen formation Collagen biosynthesis and modifying enzymes	Signaling by PDGF Signaling by FGFR in disease Cytokine Signaling in Immune system Signaling by ERBB4 Signaling by SCF-KIT Signaling by Interleukins Nuclear signaling by ERBB4 Downstream signal transduction Signaling by FGFR1 mutants Interleukin-7 signaling Signaling by FGFR mutants Interleukin-2 signaling Prolactin receptor signaling Signaling by FGFR1 fusion mutants Interleukin-3, 5 and GM-CSF signaling Signaling by Leptin Growth hormone receptor signaling
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		15 interactors: APOB ATP12A BANP CAMLG DNM2 HIST3H3 IRF3 MDM2 PEX19 PRL SGTA STAT5A UBQLN1 UBQLN4 VKORC1	72 interactors: AQP11 BMX BRCA1 BRCA2 BTK CBL CCR5 CD247 CEBPB CENPJ CRK CRKL CSNK2B CTLA4 CYP2C9 EGFR EP300 EPAS1 EPOR ERBB4 ESR1 ESR2 FN1 GHR GLUD1 GNB2 HELZ IL2RB IL2RG IL7R INSR JAK1 JAK2 JAK3 KIT LCK LEF1 MAGEA12 MAPK1 MAPK3 MRPS6 NARF NCOR2 NLK NMI NR3C1 PDGFRA PDGFRB POM121C POU2F1 PPIB PPP2CA PRMT1 PRTFDC1 PTPN1 PTPN11 PTPN2 RBMX SHC1 SRC STAP2 STAT1 STAT3 STAT5B SYK TCF12 TEK TSLP TXNDC11 UGT2B4 WASH2P ZNF596
Entrez ID		5479	6776
HPRD ID		00458	03301
Ensembl ID		ENSG00000166794	ENSG00000126561
Uniprot IDs		P23284	A8K6I5 K7EK35 P42229 Q59GY7
PDB IDs		1CYN 3ICH 3ICI
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Mitotic Cell Cycle JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Response To Growth Hormone Viral Process Regulation Of Body Fluid Levels Cellular Response To Hormone Stimulus JAK-STAT Cascade Positive Regulation Of Mitotic Cell Cycle Phase Transition Lactation Positive Regulation Of Cell Cycle Phase Transition Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Cycle Negative Regulation Of Lipid Binding Negative Regulation Of Interferon-beta Biosynthetic Process Cellular Response To UV-C Positive Regulation Of Mast Cell Differentiation Cellular Response To Vitamin B1 Regulation Of Developmental Growth Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Receptor Metabolic Process Immune System Process Negative Regulation Of Membrane Tubulation MDA-5 Signaling Pathway Macrophage Apoptotic Process Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Steroid Metabolic Process Regulation Of Multicellular Organism Growth Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Mast Cell Differentiation Development Of Secondary Male Sexual Characteristics Regulation Of Mitotic Cell Cycle Regulation Of Cytokine Biosynthetic Process Body Fluid Secretion Cellular Response To Lipid Cellular Response To Oxygen Levels Response To Hormone Traversing Start Control Point Of Mitotic Cell Cycle Peroxisome Membrane Biogenesis Response To Peptide Hormone Cellular Response To Organonitrogen Compound Negative Regulation Of Mast Cell Apoptotic Process Response To Vitamin B1 Response To Ether Negative Regulation Of Defense Response To Virus By Host	Cellular Response To Organic Substance Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Hormone Cell Surface Receptor Signaling Pathway Cellular Response To Hormone Stimulus Protein Autophosphorylation Cellular Response To Stimulus Immune Response Signal Transduction Immune System Process Cellular Response To Organonitrogen Compound Peptidyl-tyrosine Phosphorylation Signaling Cell Communication Cellular Response To Cytokine Stimulus Regulation Of Immune Response Defense Response Response To Cytokine Positive Regulation Of Cellular Metabolic Process JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Peptidyl-amino Acid Modification Intracellular Signal Transduction Growth Hormone Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Cellular Response To Peptide Hormone Stimulus Response To Stimulus Cellular Response To Growth Hormone Stimulus Innate Immune Response Cellular Response To Peptide Response To Organonitrogen Compound Regulation Of Immune System Process Cellular Response To Growth Factor Stimulus Regulation Of Cell Proliferation Organ Development Response To Growth Factor Cytokine-mediated Signaling Pathway JAK-STAT Cascade Regulation Of MAPK Cascade Response To Peptide Hormone Neurotrophin TRK Receptor Signaling Pathway Response To Peptide Fc Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Kinase Activity Response To Growth Hormone Positive Regulation Of Metabolic Process Neurotrophin Signaling Pathway Anatomical Structure Development
Tagcloud ?		abeta abundance accompanies ad animal biomarkers cytokines diverse elisa immunostaining isotope key labeling lack lc microglia microglial ms nervous neurodegenerative neuroinflammation pdia3 pdia6 proper proteomic resident serpinh1 silac validation	advantaged apor arose b8 ba character coincides committed derive die dn epo epor erythropoietin f3epor homeotic hox hypothesize naturally normally preexisting shortened subclones switch truncated unexplored uniquely
Tagcloud (Difference) ?		abeta abundance accompanies ad animal biomarkers cytokines diverse elisa immunostaining isotope key labeling lack lc microglia microglial ms nervous neurodegenerative neuroinflammation pdia3 pdia6 proper proteomic resident serpinh1 silac validation	advantaged apor arose b8 ba character coincides committed derive die dn epo epor erythropoietin f3epor homeotic hox hypothesize naturally normally preexisting shortened subclones switch truncated unexplored uniquely
Tagcloud (Intersection) ?