XRCC5 and GZMB

Number of citations of the paper that reports this interaction (PMID 8760815)
7

Data Source:
BioGRID (enzymatic study)

		XRCC5	GZMB
Gene Name		X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
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Gene Ontology Annotations	Cellular Component	Nuclear Telomere Cap Complex Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm Nucleolus Cytosol Plasma Membrane Membrane Ku70:Ku80 Complex Nonhomologous End Joining Complex	Immunological Synapse Nucleus Cytoplasm Cytosol Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	DNA Binding Damaged DNA Binding Double-stranded DNA Binding Double-stranded Telomeric DNA Binding ATP-dependent DNA Helicase Activity Protein Binding ATP Binding Protein C-terminus Binding Ubiquitin Protein Ligase Binding Telomeric DNA Binding Transcription Regulatory Region DNA Binding Poly(A) RNA Binding 5'-deoxyribose-5-phosphate Lyase Activity	Serine-type Endopeptidase Activity Protein Binding Serine-type Peptidase Activity
	Biological Process	Telomere Maintenance DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Transcription, DNA-templated Brain Development Cell Proliferation Viral Process Positive Regulation Of Type I Interferon Production DNA Duplex Unwinding Response To Drug Innate Immune Response Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Neurogenesis Hematopoietic Stem Cell Differentiation Cellular Response To Fatty Acid Cellular Hyperosmotic Salinity Response Cellular Response To X-ray Establishment Of Integrated Proviral Latency	Proteolysis Apoptotic Process Immune Response Notch Signaling Pathway Granzyme-mediated Apoptotic Signaling Pathway Protein Processing Cytolysis Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Pathways		Cytosolic sensors of pathogen-associated DNA HIV Infection Processing of DNA ends prior to end rejoining Integration of provirus Early Phase of HIV Life Cycle HIV Life Cycle Nonhomologous End-joining (NHEJ) STING mediated induction of host immune responses Double-Strand Break Repair IRF3-mediated induction of type I IFN 2-LTR circle formation Innate Immune System	Signaling by NOTCH2 Signaling by NOTCH Activation, myristolyation of BID and translocation to mitochondria Programmed Cell Death NOTCH2 intracellular domain regulates transcription Intrinsic Pathway for Apoptosis
Drugs			Alpha-D-Mannose
Diseases
GWAS			Vitiligo ( 20410501)
Protein-Protein Interactions		47 interactors: APEX1 APLF AR ATM ATR BAZ1A BRCA1 CD40 CDC16 CEBPA CHAF1A COIL CSNK2A1 ELF3 GZMA GZMB HSF1 LIG3 MSX2 NAA15 NBN NCOA6 NDRG1 ORC2 PARP1 PCNA PDX1 PGR POLA1 POLD1 POLE POLR2A PRKDC RBM14 RUNX2 SGOL1 SUMO1 SUPT4H1 SUPT5H TCF4 TERF2IP TERT TOP2B TYK2 VAV1 WRN XRCC6	26 interactors: BID CASP3 CASP7 CASP8 CASP9 CD2AP CHRM3 DFFA GRIA3 IGF2R LMNA LMNB1 PARP1 PRF1 PRKDC PTGES3 PTK2 RAB27A SERPINB9 SRGN TUBA1A UBE4A UBE4B XRCC4 XRCC5 XRCC6
Entrez ID		7520	3002
HPRD ID		08935	00476
Ensembl ID		ENSG00000079246	ENSG00000100453
Uniprot IDs		P13010	P10144 Q67BC3
PDB IDs		1JEQ 1JEY 1Q2Z 1RW2 3RZ9	1FQ3 1IAU
Enriched GO Terms of Interacting Partners?		DNA Metabolic Process Telomere Maintenance DNA Replication DNA Recombination DNA Repair Cellular Response To DNA Damage Stimulus Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Cellular Response To Stress Double-strand Break Repair Regulation Of Nitrogen Compound Metabolic Process Response To Stress Chromosome Organization Biosynthetic Process DNA-dependent DNA Replication Positive Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Organelle Organization Regulation Of Metabolic Process Cell Cycle Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process RNA Biosynthetic Process RNA Metabolic Process Regulation Of Gene Expression Positive Regulation Of Gene Expression Cellular Response To Stimulus Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Stimulus Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Mitotic Recombination Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process DNA Strand Elongation Base-excision Repair Transcription From RNA Polymerase II Promoter Cell Cycle Process Negative Regulation Of Biosynthetic Process	Apoptotic Process Programmed Cell Death Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell Death Death Execution Phase Of Apoptosis Cellular Response To Stimulus Response To Stimulus Apoptotic Signaling Pathway Protein Processing Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Apoptotic Process Telomere Maintenance Glial Cell Apoptotic Process Regulation Of Cell Death Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Intrinsic Apoptotic Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Establishment Of Integrated Proviral Latency Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Zymogen Activation Response To Abiotic Stimulus Establishment Of Viral Latency Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cell Death Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Signal Transduction Response To Radiation Response To Stress Positive Regulation Of Peptidase Activity Immune Response Immune System Development Double-strand Break Repair Positive Regulation Of Proteolysis Immune System Process Signaling Cellular Hyperosmotic Salinity Response Cell Communication Cellular Response To DNA Damage Stimulus Cellular Response To Stress Regulation Of Endopeptidase Activity Hemopoiesis Organ Development V(D)J Recombination Regulation Of Peptidase Activity
Tagcloud ?		annotation bub california cruz databases david deterioration downloaded exploring geo gse27567 h17 hub inheritance mendelian networks omim omnibus ranked santa topological visualization xpc xrcc4 ybx1 yy1 zfhx3 zfp36 zmat3	adhered autonomous basement cleaved cleaves compromised constituents cremaster cytotoxic deficit destruction diapedesis ectromelia effector enabled expediting extend granzyme homing inflamed interplay intravital killer lamellipodia lymphocytes migrating null proteomic venules
Tagcloud (Difference) ?		annotation bub california cruz databases david deterioration downloaded exploring geo gse27567 h17 hub inheritance mendelian networks omim omnibus ranked santa topological visualization xpc xrcc4 ybx1 yy1 zfhx3 zfp36 zmat3	adhered autonomous basement cleaved cleaves compromised constituents cremaster cytotoxic deficit destruction diapedesis ectromelia effector enabled expediting extend granzyme homing inflamed interplay intravital killer lamellipodia lymphocytes migrating null proteomic venules
Tagcloud (Intersection) ?