XRCC5 and GZMB

Number of citations of the paper that reports this interaction (PubMedID 8760815)
52

Data Source:
BioGRID (enzymatic study)

		XRCC5	GZMB
Description		X-ray repair cross complementing 5	granzyme B
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Extracellular Region Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol Plasma Membrane DNA-dependent Protein Kinase-DNA Ligase 4 Complex Membrane Small-subunit Processome Protein-containing Complex Protein-DNA Complex Secretory Granule Lumen Ku70:Ku80 Complex DNA-dependent Protein Kinase Complex Nonhomologous End Joining Complex Site Of DNA Damage Ribonucleoprotein Complex	Immunological Synapse Extracellular Region Extracellular Space Nucleus Cytoplasm Lysosome Cytosol Membrane Cytolytic Granule Cytolytic Granule Lumen
	Molecular Function	Nucleotide Binding Transcription Cis-regulatory Region Binding DNA Binding DNA Helicase Activity Damaged DNA Binding Double-stranded DNA Binding Double-stranded Telomeric DNA Binding RNA Binding Helicase Activity Protein Binding ATP Binding Enzyme Activator Activity ATP-dependent Activity, Acting On DNA Hydrolase Activity ATP Hydrolysis Activity Ubiquitin Protein Ligase Binding U3 SnoRNA Binding Telomeric DNA Binding Protein-containing Complex Binding DNA End Binding 5'-deoxyribose-5-phosphate Lyase Activity	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Telomere Maintenance Recombinational Repair Activation Of Innate Immune Response Immune System Process DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination DNA Damage Response Telomere Maintenance Via Telomerase Negative Regulation Of Macromolecule Biosynthetic Process Neurogenesis Regulation Of Telomere Maintenance Small-subunit Processome Assembly Ribosome Biogenesis Innate Immune Response Positive Regulation Of Protein Kinase Activity Negative Regulation Of DNA-templated Transcription Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Neurogenesis Hematopoietic Stem Cell Differentiation Protein Localization To Chromosome, Telomeric Region Hematopoietic Stem Cell Proliferation Cellular Response To Gamma Radiation Negative Regulation Of T-circle Formation Cellular Response To Leukemia Inhibitory Factor	Plasma Membrane Repair Positive Regulation Of Immune Response To Tumor Cell Proteolysis Apoptotic Process Protein Secretion Negative Regulation Of Translation Killing Of Cells Of Another Organism Natural Killer Cell Mediated Cytotoxicity Ceramide Biosynthetic Process Proteolysis Involved In Protein Catabolic Process Protein Maturation Pyroptotic Inflammatory Response Granzyme-mediated Programmed Cell Death Signaling Pathway Pyroptotic Cell Death Positive Regulation Of Establishment Of Protein Localization To Mitochondrion
Pathways		2-LTR circle formation Cytosolic sensors of pathogen-associated DNA IRF3-mediated induction of type I IFN Nonhomologous End-Joining (NHEJ) Neutrophil degranulation	NOTCH2 intracellular domain regulates transcription Pyroptosis Activation, myristolyation of BID and translocation to mitochondria Nuclear events stimulated by ALK signaling in cancer
Drugs
Diseases
GWAS			Blood protein levels ( 30072576) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Interleukin-10 levels in non-alcoholic fatty liver disease x mastiha supplementation interaction ( 34025683) Vitiligo ( 20410501 27723757)
Interacting Genes		59 interacting genes: APEX1 AR ATM ATR BAZ1A BRCA1 CD40 CDC16 CEBPA CHAF1A COIL CSNK2A1 DEAF1 DUX4 ELF3 ERCC6 GZMA GZMB HSF1 HSPB1 LIG3 LINC01554 MSX2 NAA15 NBN NCOA6 NDRG1 ORC2 PARP1 PCNA PDX1 PGR POLA1 POLD1 POLE POLR2A PRKDC PTEN RBM14 RNF126 RUNX2 SGO1 SRPK2 SUMO2 SUPT4H1 SUPT5H TCF4 TERF2IP TERT TOP1 TOP2B TYK2 UBC UBE2I UCHL3 VAV1 WRN XRCC6 ZBTB7A	26 interacting genes: BID CASP3 CASP7 CASP8 CASP9 CD2AP CHRM3 DFFA GRIA3 IGF2R LMNA LMNB1 PARP1 PRF1 PRKDC PTGES3 PTK2 RAB27A SERPINB9 SRGN TUBA1A UBE4A UBE4B XRCC4 XRCC5 XRCC6
Entrez ID		7520	3002
HPRD ID		08935	00476
Ensembl ID		ENSG00000079246	ENSG00000100453
Uniprot IDs		P13010	J3KQ52 P10144 Q67BC3 Q6XGZ4
PDB IDs		1JEQ 1JEY 1Q2Z 1RW2 3RZ9 5Y3R 6ERF 6ERG 6ERH 6ZH6 6ZHA 6ZHE 7AXZ 7K0Y 7K17 7K1J 7K1K 7K1N 7LSY 7LT3 7NFC 7NFE 7SGL 7SU3 7SUD 7Z6O 7Z87 7Z88 7ZT6 7ZVT 7ZWA 7ZYG 8AG4 8AG5 8ASC 8BH3 8BHV 8BHY 8BOT 8EZA 8EZB 8RD4	1FQ3 1IAU
Enriched GO Terms of Interacting Partners?		DNA Metabolic Process Nucleic Acid Metabolic Process Nucleus Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA Repair DNA Damage Response Macromolecule Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Response To Stress Regulation Of Macromolecule Metabolic Process Double-strand Break Repair Positive Regulation Of DNA Metabolic Process Chromosome, Telomeric Region Regulation Of DNA Metabolic Process Telomere Maintenance Positive Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process DNA Binding Response To Gamma Radiation Regulation Of RNA Metabolic Process Cellular Response To Stress Double-strand Break Repair Via Nonhomologous End Joining Positive Regulation Of Macromolecule Biosynthetic Process Telomere Organization Regulation Of DNA-templated Transcription Regulation Of Metabolic Process Regulation Of DNA Repair Positive Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process DNA Replication Regulation Of Double-strand Break Repair Chromatin Binding Nucleobase-containing Compound Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Chromosome Organization Positive Regulation Of DNA-templated Transcription DNA Recombination Negative Regulation Of DNA Metabolic Process DNA Strand Elongation Regulation Of Gene Expression Recombinational Repair Response To Ionizing Radiation	DNA-dependent Protein Kinase-DNA Ligase 4 Complex Nonhomologous End Joining Complex Response To Radiation Positive Regulation Of Programmed Cell Death Programmed Cell Death Cell Death Regulation Of Programmed Cell Death DNA-dependent Protein Kinase Complex Apoptotic Process Regulation Of Apoptotic Process Response To Anesthetic Response To Ionizing Radiation Cellular Response To Stress Protein Processing Protein Maturation Response To Cobalt Ion Telomere Maintenance Pyroptotic Inflammatory Response Fibroblast Apoptotic Process Protein-DNA Complex Neuron Apoptotic Process Granzyme-mediated Programmed Cell Death Signaling Pathway Leukocyte Apoptotic Process Positive Regulation Of Apoptotic Process Response To Gamma Radiation Protein-containing Complex Telomere Organization Regulation Of Neuron Apoptotic Process Death Receptor Binding Double-strand Break Repair Via Nonhomologous End Joining Structural Constituent Of Nuclear Lamina Response To Stress Protein Poly-ADP-ribosylation Cysteine-type Endopeptidase Activity Response To UV Positive Regulation Of Neuron Apoptotic Process Enzyme Activator Activity Macromolecule Metabolic Process DNA End Binding Ku70:Ku80 Complex Small-subunit Processome Assembly Chromosome, Telomeric Region Execution Phase Of Apoptosis Response To Light Stimulus Regulation Of Immune Response Apoptotic Signaling Pathway Response To Metal Ion Immune System Process Response To X-ray Regulation Of Immune System Process
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