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XRCC5 and PCNA
Number of citations of the paper that reports this interaction (PubMedID
12393188
)
0
Data Source:
HPRD
(in vitro, in vivo)
XRCC5
PCNA
Description
X-ray repair cross complementing 5
proliferating cell nuclear antigen
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nuclear Telomere Cap Complex
Extracellular Region
Nucleus
Nucleoplasm
Chromosome
Nucleolus
Cytoplasm
Cytosol
Plasma Membrane
DNA-dependent Protein Kinase-DNA Ligase 4 Complex
Membrane
Small-subunit Processome
Protein-containing Complex
Protein-DNA Complex
Secretory Granule Lumen
Ku70:Ku80 Complex
DNA-dependent Protein Kinase Complex
Nonhomologous End Joining Complex
Site Of DNA Damage
Ribonucleoprotein Complex
Cyclin-dependent Protein Kinase Holoenzyme Complex
Chromosome, Telomeric Region
Chromatin
Male Germ Cell Nucleus
Nucleus
Nuclear Lamina
Nucleoplasm
Replication Fork
Centrosome
Nuclear Body
Replisome
Nuclear Replication Fork
PCNA Complex
Extracellular Exosome
PCNA-p21 Complex
Molecular Function
Nucleotide Binding
Transcription Cis-regulatory Region Binding
DNA Binding
DNA Helicase Activity
Damaged DNA Binding
Double-stranded DNA Binding
Double-stranded Telomeric DNA Binding
RNA Binding
Helicase Activity
Protein Binding
ATP Binding
Enzyme Activator Activity
ATP-dependent Activity, Acting On DNA
Hydrolase Activity
ATP Hydrolysis Activity
Ubiquitin Protein Ligase Binding
U3 SnoRNA Binding
Telomeric DNA Binding
Protein-containing Complex Binding
DNA End Binding
5'-deoxyribose-5-phosphate Lyase Activity
Purine-specific Mismatch Base Pair DNA N-glycosylase Activity
DNA Binding
Chromatin Binding
Damaged DNA Binding
Protein Binding
Enzyme Binding
Nuclear Estrogen Receptor Binding
DNA Polymerase Processivity Factor Activity
Receptor Tyrosine Kinase Binding
Dinucleotide Insertion Or Deletion Binding
MutLalpha Complex Binding
Histone Acetyltransferase Binding
Identical Protein Binding
Protein-containing Complex Binding
DNA Polymerase Binding
Biological Process
Telomere Maintenance
Recombinational Repair
Activation Of Innate Immune Response
Immune System Process
DNA Repair
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
DNA Recombination
DNA Damage Response
Telomere Maintenance Via Telomerase
Negative Regulation Of Macromolecule Biosynthetic Process
Neurogenesis
Regulation Of Telomere Maintenance
Small-subunit Processome Assembly
Ribosome Biogenesis
Innate Immune Response
Positive Regulation Of Protein Kinase Activity
Negative Regulation Of DNA-templated Transcription
Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Neurogenesis
Hematopoietic Stem Cell Differentiation
Protein Localization To Chromosome, Telomeric Region
Hematopoietic Stem Cell Proliferation
Cellular Response To Gamma Radiation
Negative Regulation Of T-circle Formation
Cellular Response To Leukemia Inhibitory Factor
Negative Regulation Of Transcription By RNA Polymerase II
DNA Replication
Leading Strand Elongation
Regulation Of DNA Replication
DNA Repair
Base-excision Repair, Gap-filling
Mismatch Repair
Chromatin Organization
DNA Damage Response
Response To Oxidative Stress
Heart Development
Translesion Synthesis
Epithelial Cell Differentiation
Replication Fork Processing
Positive Regulation Of Deoxyribonuclease Activity
Response To Estradiol
Response To Lipid
Cellular Response To UV
Estrous Cycle
Positive Regulation Of DNA Repair
Positive Regulation Of DNA Replication
Response To Cadmium Ion
Cellular Response To Hydrogen Peroxide
Cellular Response To Xenobiotic Stimulus
Response To Dexamethasone
Liver Regeneration
Positive Regulation Of DNA-directed DNA Polymerase Activity
Response To L-glutamate
Mitotic Telomere Maintenance Via Semi-conservative Replication
Pathways
2-LTR circle formation
Cytosolic sensors of pathogen-associated DNA
IRF3-mediated induction of type I IFN
Nonhomologous End-Joining (NHEJ)
Neutrophil degranulation
Translesion synthesis by REV1
Recognition of DNA damage by PCNA-containing replication complex
Translesion Synthesis by POLH
Transcription of E2F targets under negative control by DREAM complex
Polymerase switching on the C-strand of the telomere
Processive synthesis on the C-strand of the telomere
Telomere C-strand (Lagging Strand) Synthesis
Removal of the Flap Intermediate from the C-strand
SUMOylation of DNA replication proteins
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
PCNA-Dependent Long Patch Base Excision Repair
Translesion synthesis by POLK
Translesion synthesis by POLI
Termination of translesion DNA synthesis
HDR through Homologous Recombination (HRR)
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Polymerase switching
Removal of the Flap Intermediate
Processive synthesis on the lagging strand
G1/S-Specific Transcription
E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Liothyronine
Acetylsalicylic acid
Diseases
GWAS
Interacting Genes
59 interacting genes:
APEX1
AR
ATM
ATR
BAZ1A
BRCA1
CD40
CDC16
CEBPA
CHAF1A
COIL
CSNK2A1
DEAF1
DUX4
ELF3
ERCC6
GZMA
GZMB
HSF1
HSPB1
LIG3
LINC01554
MSX2
NAA15
NBN
NCOA6
NDRG1
ORC2
PARP1
PCNA
PDX1
PGR
POLA1
POLD1
POLE
POLR2A
PRKDC
PTEN
RBM14
RNF126
RUNX2
SGO1
SRPK2
SUMO2
SUPT4H1
SUPT5H
TCF4
TERF2IP
TERT
TOP1
TOP2B
TYK2
UBC
UBE2I
UCHL3
VAV1
WRN
XRCC6
ZBTB7A
142 interacting genes:
ALDOA
APEX1
APEX2
ATAD5
ATM
BAZ1B
CBX1
CCNB1
CCND1
CCND3
CCNO
CDC25C
CDC6
CDK1
CDK2
CDK5
CDK6
CDKN1A
CDKN1C
CDKN2A
CDT1
CHAF1A
CHTF18
CHTF8
CMTM5
CREBBP
DHX9
DNMT1
DNTT
DNTTIP2
DSCC1
DTL
EGFR
ENO1
EP300
ERCC5
ERCC6
ERRFI1
ESCO2
EXO1
FAN1
FANCD2
FANCL
FBH1
FEN1
GADD45A
GADD45B
GADD45G
GAPDH
GCK
GPI
HDAC1
HUS1
ING1
KCTD13
KMT5A
LDHA
LIG1
MCL1
MGMT
MLH1
MLH3
MSH2
MSH3
MSH6
MTOR
MUTYH
MYBBP1A
NEDD8
NIPBL
NMRAL1
NSD2
NTHL1
NUTF2
PARP1
PARP10
PARPBP
PCLAF
PFKM
PGAM1
PGK1
PKLR
PMS2
POLB
POLD1
POLD2
POLD3
POLD4
POLDIP2
POLE
POLH
POLI
POLK
POLL
POLM
PPP1CA
PRKDC
PTEN
PTMA
RAD18
RAD9A
RBBP8
RECQL5
RFC1
RFC2
RFC3
RFC4
RFC5
RFWD3
RPA1
S100A8
SDE2
SEC23IP
SIVA1
SLC30A8
SMARCAD1
SPG21
SUB1
SUMO1
TCOF1
TDG
TIRAP
TMEM218
TPI1
UBB
UBC
UBE2A
UBE2B
UBE2D3
UBE2I
UBE3D
UHRF1
UNG
USP4
WDR48
WRN
XPA
XRCC1
XRCC5
XRCC6
YBX1
ZBTB1
Entrez ID
7520
5111
HPRD ID
08935
01456
Ensembl ID
ENSG00000079246
ENSG00000132646
Uniprot IDs
P13010
P12004
PDB IDs
1JEQ
1JEY
1Q2Z
1RW2
3RZ9
5Y3R
6ERF
6ERG
6ERH
6ZH6
6ZHA
6ZHE
7AXZ
7K0Y
7K17
7K1J
7K1K
7K1N
7LSY
7LT3
7NFC
7NFE
7SGL
7SU3
7SUD
7Z6O
7Z87
7Z88
7ZT6
7ZVT
7ZWA
7ZYG
8AG4
8AG5
8ASC
8BH3
8BHV
8BHY
8BOT
8EZA
8EZB
8RD4
1AXC
1U76
1U7B
1UL1
1VYJ
1VYM
1W60
2ZVK
2ZVL
2ZVM
3JA9
3P87
3TBL
3VKX
3WGW
4D2G
4RJF
4ZTD
5E0T
5E0U
5E0V
5IY4
5MAV
5MLO
5MLW
5MOM
5YCO
5YD8
6CBI
6EHT
6FCM
6FCN
6GIS
6GWS
6HVO
6K3A
6QC0
6QCG
6S1M
6S1N
6S1O
6TNY
6TNZ
6VVO
7EFA
7KQ0
7KQ1
7M5L
7M5M
7M5N
7NV0
7NV1
7QNZ
7QO1
8B8T
8COB
8E84
8F5Q
8GCJ
8GL9
8GLA
8UI7
8UI8
8UI9
8UII
8UMT
8UMU
8UMV
8UMW
8UMY
8UN0
8YJH
8YJL
8YJQ
8YJR
8YJS
8YJU
8YJV
8YJW
8YJZ
9B8S
9B8T
9CG4
9CHM
9CL7
9CMA
9EOA
9F6D
9F6E
9F6F
9GY0
Enriched GO Terms of Interacting Partners
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DNA Metabolic Process
Nucleic Acid Metabolic Process
Nucleus
Nucleoplasm
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
DNA Repair
DNA Damage Response
Macromolecule Metabolic Process
Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
Response To Stress
Regulation Of Macromolecule Metabolic Process
Double-strand Break Repair
Positive Regulation Of DNA Metabolic Process
Chromosome, Telomeric Region
Regulation Of DNA Metabolic Process
Telomere Maintenance
Positive Regulation Of Metabolic Process
Regulation Of RNA Biosynthetic Process
DNA Binding
Response To Gamma Radiation
Regulation Of RNA Metabolic Process
Cellular Response To Stress
Double-strand Break Repair Via Nonhomologous End Joining
Positive Regulation Of Macromolecule Biosynthetic Process
Telomere Organization
Regulation Of DNA-templated Transcription
Regulation Of Metabolic Process
Regulation Of DNA Repair
Positive Regulation Of RNA Biosynthetic Process
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Biosynthetic Process
Regulation Of Macromolecule Biosynthetic Process
DNA Replication
Regulation Of Double-strand Break Repair
Chromatin Binding
Nucleobase-containing Compound Biosynthetic Process
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Chromosome Organization
Positive Regulation Of DNA-templated Transcription
DNA Recombination
Negative Regulation Of DNA Metabolic Process
DNA Strand Elongation
Regulation Of Gene Expression
Recombinational Repair
Response To Ionizing Radiation
DNA Damage Response
DNA Repair
DNA Metabolic Process
Cellular Response To Stress
Nucleobase-containing Compound Metabolic Process
Nucleic Acid Metabolic Process
Nucleus
Nucleoplasm
Response To Stress
DNA Replication
DNA Recombination
Macromolecule Metabolic Process
Damaged DNA Binding
Double-strand Break Repair
DNA Biosynthetic Process
Regulation Of DNA Metabolic Process
Response To Radiation
DNA Binding
Postreplication Repair
Response To UV
Positive Regulation Of DNA Metabolic Process
DNA Synthesis Involved In DNA Repair
Recombinational Repair
Base-excision Repair
Chromosome Organization
DNA-templated DNA Replication
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Double-strand Break Repair Via Homologous Recombination
Mismatch Repair
DNA-directed DNA Polymerase Activity
Response To Light Stimulus
Translesion Synthesis
Somatic Hypermutation Of Immunoglobulin Genes
Regulation Of DNA Recombination
Negative Regulation Of Metabolic Process
DNA Clamp Loader Activity
Somatic Diversification Of Immune Receptors Via Somatic Mutation
Regulation Of Cell Cycle Phase Transition
Nucleobase-containing Compound Biosynthetic Process
Regulation Of Primary Metabolic Process
Mitotic DNA Integrity Checkpoint Signaling
Somatic Diversification Of Immunoglobulins
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Cell Cycle Process
Negative Regulation Of DNA Metabolic Process
DNA Polymerase Activity
Somatic Cell DNA Recombination
Ctf18 RFC-like Complex
Glycolytic Process
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