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XRCC5 and MSX2
Number of citations of the paper that reports this interaction (PubMedID
12145310
)
0
Data Source:
HPRD
(in vitro)
XRCC5
MSX2
Description
X-ray repair cross complementing 5
msh homeobox 2
Image
No pdb structure
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nuclear Telomere Cap Complex
Extracellular Region
Nucleus
Nucleoplasm
Chromosome
Nucleolus
Cytoplasm
Cytosol
Plasma Membrane
DNA-dependent Protein Kinase-DNA Ligase 4 Complex
Membrane
Small-subunit Processome
Protein-containing Complex
Protein-DNA Complex
Secretory Granule Lumen
Ku70:Ku80 Complex
DNA-dependent Protein Kinase Complex
Nonhomologous End Joining Complex
Site Of DNA Damage
Ribonucleoprotein Complex
Chromatin
Nucleus
Transcription Regulator Complex
Cytosol
Nuclear Speck
Molecular Function
Nucleotide Binding
Transcription Cis-regulatory Region Binding
DNA Binding
DNA Helicase Activity
Damaged DNA Binding
Double-stranded DNA Binding
Double-stranded Telomeric DNA Binding
RNA Binding
Helicase Activity
Protein Binding
ATP Binding
Enzyme Activator Activity
ATP-dependent Activity, Acting On DNA
Hydrolase Activity
ATP Hydrolysis Activity
Ubiquitin Protein Ligase Binding
U3 SnoRNA Binding
Telomeric DNA Binding
Protein-containing Complex Binding
DNA End Binding
5'-deoxyribose-5-phosphate Lyase Activity
Transcription Cis-regulatory Region Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA Binding
Protein Binding
Sequence-specific DNA Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Telomere Maintenance
Recombinational Repair
Activation Of Innate Immune Response
Immune System Process
DNA Repair
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
DNA Recombination
DNA Damage Response
Telomere Maintenance Via Telomerase
Negative Regulation Of Macromolecule Biosynthetic Process
Neurogenesis
Regulation Of Telomere Maintenance
Small-subunit Processome Assembly
Ribosome Biogenesis
Innate Immune Response
Positive Regulation Of Protein Kinase Activity
Negative Regulation Of DNA-templated Transcription
Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Neurogenesis
Hematopoietic Stem Cell Differentiation
Protein Localization To Chromosome, Telomeric Region
Hematopoietic Stem Cell Proliferation
Cellular Response To Gamma Radiation
Negative Regulation Of T-circle Formation
Cellular Response To Leukemia Inhibitory Factor
Negative Regulation Of Transcription By RNA Polymerase II
Ossification
Osteoblast Differentiation
Chondrocyte Development
Osteoblast Development
Outflow Tract Septum Morphogenesis
Outflow Tract Morphogenesis
Cardiac Conduction System Development
Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Endochondral Bone Growth
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Cell Population Proliferation
Animal Organ Morphogenesis
Anterior/posterior Pattern Specification
Signal Transduction Involved In Regulation Of Gene Expression
Embryonic Limb Morphogenesis
BMP Signaling Pathway
Positive Regulation Of BMP Signaling Pathway
Embryonic Forelimb Morphogenesis
Embryonic Hindlimb Morphogenesis
Wound Healing, Spreading Of Epidermal Cells
Embryonic Nail Plate Morphogenesis
Wound Healing
Odontogenesis
Embryonic Digit Morphogenesis
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Fat Cell Differentiation
Negative Regulation Of Keratinocyte Differentiation
Positive Regulation Of Osteoblast Differentiation
Negative Regulation Of DNA-templated Transcription
Embryonic Morphogenesis
Stem Cell Differentiation
Cartilage Development
Positive Regulation Of Timing Of Catagen
Bone Trabecula Formation
Bone Morphogenesis
Cranial Suture Morphogenesis
Frontal Suture Morphogenesis
Branching Involved In Mammary Gland Duct Morphogenesis
Mammary Gland Epithelium Development
Cell Surface Receptor Signaling Pathway Involved In Heart Development
Enamel Mineralization
Cellular Response To Growth Factor Stimulus
Cellular Response To Estradiol Stimulus
Activation Of Meiosis
Mesenchymal Cell Apoptotic Process
Positive Regulation Of Mesenchymal Cell Apoptotic Process
Pathways
2-LTR circle formation
Cytosolic sensors of pathogen-associated DNA
IRF3-mediated induction of type I IFN
Nonhomologous End-Joining (NHEJ)
Neutrophil degranulation
Regulation of RUNX2 expression and activity
Drugs
Diseases
Enlarged parietal foramina/cranium bifidum
Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome
GWAS
Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) (
28090653
)
Alzheimer's disease (
33074286
)
Blond vs. brown/black hair color (
30531825
)
Chin dimples (
27182965
)
Chronotype (
30696823
)
Depressive symptoms (SSRI exposure interaction) (
25649181
)
Metabolite levels (
23823483
)
Night sleep phenotypes (
27126917
)
Red vs. brown/black hair color (
30531825
)
Resistant hypertension (
30237584
)
Stroke (
26089329
)
Interacting Genes
59 interacting genes:
APEX1
AR
ATM
ATR
BAZ1A
BRCA1
CD40
CDC16
CEBPA
CHAF1A
COIL
CSNK2A1
DEAF1
DUX4
ELF3
ERCC6
GZMA
GZMB
HSF1
HSPB1
LIG3
LINC01554
MSX2
NAA15
NBN
NCOA6
NDRG1
ORC2
PARP1
PCNA
PDX1
PGR
POLA1
POLD1
POLE
POLR2A
PRKDC
PTEN
RBM14
RNF126
RUNX2
SGO1
SRPK2
SUMO2
SUPT4H1
SUPT5H
TCF4
TERF2IP
TERT
TOP1
TOP2B
TYK2
UBC
UBE2I
UCHL3
VAV1
WRN
XRCC6
ZBTB7A
53 interacting genes:
ATXN1
CCDC102B
CEBPA
CLIC3
DLX2
DLX5
EPHB6
FBXW2
FOXH1
GATA2
GTF2F1
GTF2F2
HOXC9
LENG8
MAGED1
MAPK1
MAPK1IP1L
MGAT5B
MSX1
NAF1
NR3C1
PATZ1
PIAS2
PITX1
POLR3D
POU1F1
POU2AF1
POU2F2
POU6F2
PPARG
PRR13
RBPMS2
RHOXF2
RUNX2
SMAP2
SOX5
SPEN
TCF7L2
TENT5D
TLE1
TLE2
TLE5
TLX3
TOLLIP
TSSK3
VEZF1
XRCC5
XRCC6
YTHDF1
ZBTB17
ZC3H10
ZDHHC2
ZFHX3
Entrez ID
7520
4488
HPRD ID
08935
00421
Ensembl ID
ENSG00000079246
ENSG00000120149
Uniprot IDs
P13010
D6RIS4
P35548
PDB IDs
1JEQ
1JEY
1Q2Z
1RW2
3RZ9
5Y3R
6ERF
6ERG
6ERH
6ZH6
6ZHA
6ZHE
7AXZ
7K0Y
7K17
7K1J
7K1K
7K1N
7LSY
7LT3
7NFC
7NFE
7SGL
7SU3
7SUD
7Z6O
7Z87
7Z88
7ZT6
7ZVT
7ZWA
7ZYG
8AG4
8AG5
8ASC
8BH3
8BHV
8BHY
8BOT
8EZA
8EZB
8RD4
Enriched GO Terms of Interacting Partners
?
DNA Metabolic Process
Nucleic Acid Metabolic Process
Nucleus
Nucleoplasm
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
DNA Repair
DNA Damage Response
Macromolecule Metabolic Process
Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
Response To Stress
Regulation Of Macromolecule Metabolic Process
Double-strand Break Repair
Positive Regulation Of DNA Metabolic Process
Chromosome, Telomeric Region
Regulation Of DNA Metabolic Process
Telomere Maintenance
Positive Regulation Of Metabolic Process
Regulation Of RNA Biosynthetic Process
DNA Binding
Response To Gamma Radiation
Regulation Of RNA Metabolic Process
Cellular Response To Stress
Double-strand Break Repair Via Nonhomologous End Joining
Positive Regulation Of Macromolecule Biosynthetic Process
Telomere Organization
Regulation Of DNA-templated Transcription
Regulation Of Metabolic Process
Regulation Of DNA Repair
Positive Regulation Of RNA Biosynthetic Process
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Biosynthetic Process
Regulation Of Macromolecule Biosynthetic Process
DNA Replication
Regulation Of Double-strand Break Repair
Chromatin Binding
Nucleobase-containing Compound Biosynthetic Process
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Chromosome Organization
Positive Regulation Of DNA-templated Transcription
DNA Recombination
Negative Regulation Of DNA Metabolic Process
DNA Strand Elongation
Regulation Of Gene Expression
Recombinational Repair
Response To Ionizing Radiation
Regulation Of RNA Metabolic Process
DNA Binding
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Metabolic Process
Regulation Of RNA Biosynthetic Process
Regulation Of Primary Metabolic Process
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Transcription Cis-regulatory Region Binding
Negative Regulation Of DNA-templated Transcription
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
DNA-binding Transcription Factor Activity
Chromatin
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Regulation Of Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Metabolic Process
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Nucleus
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Transcription Regulator Complex
Negative Regulation Of Biosynthetic Process
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Negative Regulation Of Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Embryonic Morphogenesis
DNA-templated Transcription
Sequence-specific Double-stranded DNA Binding
Nucleoplasm
Cell Fate Commitment
Positive Regulation Of Developmental Process
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Positive Regulation Of Cell Differentiation
Regulation Of Cell Differentiation
GABAergic Neuron Differentiation
Developmental Process
Transcription Factor TFIIF Complex
Protein-DNA Complex
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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