XRCC5 and PDX1

Number of citations of the paper that reports this interaction (PubMedID 16166097)
0

Data Source:
BioGRID (affinity chromatography technology, pull down)

		XRCC5	PDX1
Description		X-ray repair cross complementing 5	pancreatic and duodenal homeobox 1
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Extracellular Region Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol Plasma Membrane DNA-dependent Protein Kinase-DNA Ligase 4 Complex Membrane Small-subunit Processome Protein-containing Complex Protein-DNA Complex Secretory Granule Lumen Ku70:Ku80 Complex DNA-dependent Protein Kinase Complex Nonhomologous End Joining Complex Site Of DNA Damage Ribonucleoprotein Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck
	Molecular Function	Nucleotide Binding Transcription Cis-regulatory Region Binding DNA Binding DNA Helicase Activity Damaged DNA Binding Double-stranded DNA Binding Double-stranded Telomeric DNA Binding RNA Binding Helicase Activity Protein Binding ATP Binding Enzyme Activator Activity ATP-dependent Activity, Acting On DNA Hydrolase Activity ATP Hydrolysis Activity Ubiquitin Protein Ligase Binding U3 SnoRNA Binding Telomeric DNA Binding Protein-containing Complex Binding DNA End Binding 5'-deoxyribose-5-phosphate Lyase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Sequence-specific DNA Binding Protein-containing Complex Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding
	Biological Process	Telomere Maintenance Recombinational Repair Activation Of Innate Immune Response Immune System Process DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination DNA Damage Response Telomere Maintenance Via Telomerase Negative Regulation Of Macromolecule Biosynthetic Process Neurogenesis Regulation Of Telomere Maintenance Small-subunit Processome Assembly Ribosome Biogenesis Innate Immune Response Positive Regulation Of Protein Kinase Activity Negative Regulation Of DNA-templated Transcription Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Neurogenesis Hematopoietic Stem Cell Differentiation Protein Localization To Chromosome, Telomeric Region Hematopoietic Stem Cell Proliferation Cellular Response To Gamma Radiation Negative Regulation Of T-circle Formation Cellular Response To Leukemia Inhibitory Factor	Negative Regulation Of Transcription By RNA Polymerase II Liver Development Type B Pancreatic Cell Differentiation Glucose Metabolic Process Generation Of Precursor Metabolites And Energy DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Smoothened Signaling Pathway Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Response To Glucose Animal Organ Morphogenesis Response To Iron(II) Ion Response To Chlorate Glucose Mediated Signaling Pathway Regulation Of Gene Expression Morphogenesis Of Embryonic Epithelium Insulin Secretion Cell Differentiation Pancreas Development Exocrine Pancreas Development Endocrine Pancreas Development Animal Organ Regeneration Response To Nutrient Levels Positive Regulation Of Insulin Secretion Response To Vitamin Response To Lipid Response To Cytokine Response To Nicotine Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Enteroendocrine Cell Differentiation Regulation Of Cell Population Proliferation Glucose Homeostasis Response To L-leucine Response To Alkaloid Type B Pancreatic Cell Proliferation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Development Stem Cell Differentiation Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Response To Glucocorticoid Transdifferentiation Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Response To Fatty Acid Type B Pancreatic Cell Apoptotic Process Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Cellular Response To Acadesine Positive Regulation Of Type B Pancreatic Cell Proliferation Negative Regulation Of Type B Pancreatic Cell Apoptotic Process
Pathways		2-LTR circle formation Cytosolic sensors of pathogen-associated DNA IRF3-mediated induction of type I IFN Nonhomologous End-Joining (NHEJ) Neutrophil degranulation	Regulation of gene expression in beta cells Regulation of gene expression in early pancreatic precursor cells Developmental Lineage of Pancreatic Acinar Cells Developmental Lineage of Pancreatic Ductal Cells Developmental Lineage of Multipotent Pancreatic Progenitor Cells
Drugs
Diseases			Permanent neonatal diabetes mellitus (PNDM) Pancreatic agenesis Maturity onset diabetes of the young (MODY)
GWAS			Acute insulin response ( 28490609) Age at first sexual intercourse ( 34211149) Alanine aminotransferase levels ( 33547301) Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Birth weight ( 31043758) Blood sugar levels ( 29403010) Body mass index ( 26426971) Fasting blood glucose ( 22581228 25631608) Fasting blood glucose (BMI interaction) ( 22581228) Fasting plasma glucose ( 28270201) Glycated hemoglobin levels ( 28898252) Pancreatic cancer ( 25086665 26098869 29422604) Peak insulin response ( 28490609)
Interacting Genes		59 interacting genes: APEX1 AR ATM ATR BAZ1A BRCA1 CD40 CDC16 CEBPA CHAF1A COIL CSNK2A1 DEAF1 DUX4 ELF3 ERCC6 GZMA GZMB HSF1 HSPB1 LIG3 LINC01554 MSX2 NAA15 NBN NCOA6 NDRG1 ORC2 PARP1 PCNA PDX1 PGR POLA1 POLD1 POLE POLR2A PRKDC PTEN RBM14 RNF126 RUNX2 SGO1 SRPK2 SUMO2 SUPT4H1 SUPT5H TCF4 TERF2IP TERT TOP1 TOP2B TYK2 UBC UBE2I UCHL3 VAV1 WRN XRCC6 ZBTB7A	13 interacting genes: ATF3 CREB1 IAPP MAFA NEUROD1 PBX1 PCIF1 PRKDC SLC2A2 SPOP TCF3 XRCC5 XRCC6
Entrez ID		7520	3651
HPRD ID		08935	02843
Ensembl ID		ENSG00000079246	ENSG00000139515
Uniprot IDs		P13010	P52945
PDB IDs		1JEQ 1JEY 1Q2Z 1RW2 3RZ9 5Y3R 6ERF 6ERG 6ERH 6ZH6 6ZHA 6ZHE 7AXZ 7K0Y 7K17 7K1J 7K1K 7K1N 7LSY 7LT3 7NFC 7NFE 7SGL 7SU3 7SUD 7Z6O 7Z87 7Z88 7ZT6 7ZVT 7ZWA 7ZYG 8AG4 8AG5 8ASC 8BH3 8BHV 8BHY 8BOT 8EZA 8EZB 8RD4	6F8F 7KPK
Enriched GO Terms of Interacting Partners?		DNA Metabolic Process Nucleic Acid Metabolic Process Nucleus Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA Repair DNA Damage Response Macromolecule Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Response To Stress Regulation Of Macromolecule Metabolic Process Double-strand Break Repair Positive Regulation Of DNA Metabolic Process Chromosome, Telomeric Region Regulation Of DNA Metabolic Process Telomere Maintenance Positive Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process DNA Binding Response To Gamma Radiation Regulation Of RNA Metabolic Process Cellular Response To Stress Double-strand Break Repair Via Nonhomologous End Joining Positive Regulation Of Macromolecule Biosynthetic Process Telomere Organization Regulation Of DNA-templated Transcription Regulation Of Metabolic Process Regulation Of DNA Repair Positive Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process DNA Replication Regulation Of Double-strand Break Repair Chromatin Binding Nucleobase-containing Compound Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Chromosome Organization Positive Regulation Of DNA-templated Transcription DNA Recombination Negative Regulation Of DNA Metabolic Process DNA Strand Elongation Regulation Of Gene Expression Recombinational Repair Response To Ionizing Radiation	DNA-dependent Protein Kinase Complex DNA-dependent Protein Kinase-DNA Ligase 4 Complex Nonhomologous End Joining Complex Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulator Complex DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Transcription Regulator Complex Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II DNA End Binding Ku70:Ku80 Complex Small-subunit Processome Assembly Positive Regulation Of Macromolecule Biosynthetic Process Double-stranded DNA Binding Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Protein-DNA Complex DNA Binding Chromatin DNA-binding Transcription Factor Activity Regulation Of Cell Differentiation Leukocyte Differentiation B Cell Lineage Commitment Response To Gamma Radiation Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Regulation Of Cell Population Proliferation Positive Regulation Of DNA-templated Transcription RNA Polymerase II-specific DNA-binding Transcription Factor Binding 5'-deoxyribose-5-phosphate Lyase Activity Double-strand Break Repair Via Nonhomologous End Joining Immunoglobulin V(D)J Recombination Nuclear Telomere Cap Complex Double-stranded Telomeric DNA Binding Positive Regulation Of RNA Metabolic Process DNA Recombination U3 SnoRNA Binding Positive Regulation Of Cell Differentiation Positive Regulation Of Apoptotic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Nucleobase-containing Compound Metabolic Process Hormone Secretion Sequence-specific Double-stranded DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Telomere Maintenance Hormone Transport Regulation Of Gene Expression V(D)J Recombination DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
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