XRCC5 and RBM14

Number of citations of the paper that reports this interaction (PMID 11443112)
35

Data Source:
HPRD (in vitro)

		XRCC5	RBM14
Gene Name		X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)	RNA binding motif protein 14
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Gene Ontology Annotations	Cellular Component	Nuclear Telomere Cap Complex Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm Nucleolus Cytosol Plasma Membrane Membrane Ku70:Ku80 Complex Nonhomologous End Joining Complex	Nucleoplasm Transcription Factor Complex Nucleolus Mediator Complex Ribonucleoprotein Complex
	Molecular Function	DNA Binding Damaged DNA Binding Double-stranded DNA Binding Double-stranded Telomeric DNA Binding ATP-dependent DNA Helicase Activity Protein Binding ATP Binding Protein C-terminus Binding Ubiquitin Protein Ligase Binding Telomeric DNA Binding Transcription Regulatory Region DNA Binding Poly(A) RNA Binding 5'-deoxyribose-5-phosphate Lyase Activity	Nucleotide Binding RNA Polymerase II Transcription Cofactor Activity RNA Binding Protein Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Protein Binding, Bridging Poly(A) RNA Binding
	Biological Process	Telomere Maintenance DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Transcription, DNA-templated Brain Development Cell Proliferation Viral Process Positive Regulation Of Type I Interferon Production DNA Duplex Unwinding Response To Drug Innate Immune Response Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Neurogenesis Hematopoietic Stem Cell Differentiation Cellular Response To Fatty Acid Cellular Hyperosmotic Salinity Response Cellular Response To X-ray Establishment Of Integrated Proviral Latency	DNA Replication DNA Repair DNA Recombination Transcription From RNA Polymerase II Promoter Response To Hormone Histone Deacetylation Intracellular Estrogen Receptor Signaling Pathway Glucocorticoid Receptor Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways		Cytosolic sensors of pathogen-associated DNA HIV Infection Processing of DNA ends prior to end rejoining Integration of provirus Early Phase of HIV Life Cycle HIV Life Cycle Nonhomologous End-joining (NHEJ) STING mediated induction of host immune responses Double-Strand Break Repair IRF3-mediated induction of type I IFN 2-LTR circle formation Innate Immune System
Drugs
Diseases
GWAS			Bipolar disorder ( 21926972)
Protein-Protein Interactions		47 interactors: APEX1 APLF AR ATM ATR BAZ1A BRCA1 CD40 CDC16 CEBPA CHAF1A COIL CSNK2A1 ELF3 GZMA GZMB HSF1 LIG3 MSX2 NAA15 NBN NCOA6 NDRG1 ORC2 PARP1 PCNA PDX1 PGR POLA1 POLD1 POLE POLR2A PRKDC RBM14 RUNX2 SGOL1 SUMO1 SUPT4H1 SUPT5H TCF4 TERF2IP TERT TOP2B TYK2 VAV1 WRN XRCC6	11 interactors: EP300 NCOA6 NR3C1 PARP1 QKI RUNX1 RUNX2 SS18 SYT1 TARBP2 XRCC5
Entrez ID		7520	10432
HPRD ID		08935	11485
Ensembl ID		ENSG00000079246
Uniprot IDs		P13010	Q96PK6
PDB IDs		1JEQ 1JEY 1Q2Z 1RW2 3RZ9	2DNP
Enriched GO Terms of Interacting Partners?		DNA Metabolic Process Telomere Maintenance DNA Replication DNA Recombination DNA Repair Cellular Response To DNA Damage Stimulus Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Cellular Response To Stress Double-strand Break Repair Regulation Of Nitrogen Compound Metabolic Process Response To Stress Chromosome Organization Biosynthetic Process DNA-dependent DNA Replication Positive Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Organelle Organization Regulation Of Metabolic Process Cell Cycle Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process RNA Biosynthetic Process RNA Metabolic Process Regulation Of Gene Expression Positive Regulation Of Gene Expression Cellular Response To Stimulus Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Stimulus Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Mitotic Recombination Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process DNA Strand Elongation Base-excision Repair Transcription From RNA Polymerase II Promoter Cell Cycle Process Negative Regulation Of Biosynthetic Process	RNA Metabolic Process Positive Regulation Of Gene Expression Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Transcription, DNA-templated Heterocycle Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Response To Organic Substance DNA-templated Transcription, Initiation Glucocorticoid Receptor Signaling Pathway Nitrogen Compound Metabolic Process Cellular Response To Organic Substance Hemopoiesis Regulation Of Transcription, DNA-templated Immune System Development Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Biosynthetic Process Anatomical Structure Development Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Developmental Process Regulation Of Metabolic Process System Development Organ Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Immune System Process Myeloid Cell Differentiation Negative Regulation Of Gene Expression Response To Stimulus Multicellular Organismal Development Cell Differentiation Cellular Response To Stimulus Chordate Embryonic Development Anatomical Structure Morphogenesis Stem Cell Differentiation
Tagcloud ?		annotation bub california cruz databases david deterioration downloaded exploring geo gse27567 h17 hub inheritance mendelian networks omim omnibus ranked santa topological visualization xpc xrcc4 ybx1 yy1 zfhx3 zfp36 zmat3	aggregating conjugation detergent dialkylated eif4a1 g3bp glycine granular hek hnrnps identities immunocytochemistry insoluble isotope nono oligomerization pabpc1 paraspeckle proteinopathies psf ptm quantitate rgg rrm s6 silac tdp tls ubiquitination
Tagcloud (Difference) ?		annotation bub california cruz databases david deterioration downloaded exploring geo gse27567 h17 hub inheritance mendelian networks omim omnibus ranked santa topological visualization xpc xrcc4 ybx1 yy1 zfhx3 zfp36 zmat3	aggregating conjugation detergent dialkylated eif4a1 g3bp glycine granular hek hnrnps identities immunocytochemistry insoluble isotope nono oligomerization pabpc1 paraspeckle proteinopathies psf ptm quantitate rgg rrm s6 silac tdp tls ubiquitination
Tagcloud (Intersection) ?