PMS1 and MLH1

Number of citations of the paper that reports this interaction (PMID 11292842)
19

Data Source:
HPRD (two hybrid, in vivo)

		PMS1	MLH1
Gene Name		PMS1 postmeiotic segregation increased 1 (S. cerevisiae)	mutL homolog 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus MutLalpha Complex	Synaptonemal Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chiasma Membrane MutLalpha Complex
	Molecular Function	DNA Binding Single-stranded DNA Binding ATP Binding ATPase Activity Mismatched DNA Binding	Single-stranded DNA Binding Protein Binding ATP Binding ATPase Activity Guanine/thymine Mispair Binding MutSalpha Complex Binding
	Biological Process	Mismatch Repair Response To Drug	Nuclear-transcribed MRNA Poly(A) Tail Shortening Resolution Of Meiotic Recombination Intermediates DNA Repair Mismatch Repair Double-strand Break Repair Via Nonhomologous End Joining Male Meiosis Chromosome Segregation Synapsis Spermatogenesis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Somatic Hypermutation Of Immunoglobulin Genes Meiotic Metaphase I Plate Congression Isotype Switching Negative Regulation Of Mitotic Recombination Oogenesis Meiotic Spindle Midzone Assembly
Pathways			Meiotic recombination Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch Repair
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661) Subcutaneous adipose tissue ( 22589738)
Protein-Protein Interactions		1 interactors: MLH1	74 interactors: ABCC3 ABHD16A ACER3 ACTG2 AGR2 AIFM1 ALDOA ANXA6 AP2B1 APRT ARAF ASS1 ATF2 BLM BRCA1 CAB39L CAPN5 CASP3 CKAP4 CKB CXorf57 DDX47 EEF1G EEF2 EIF2A ELP6 EXO1 EXOC3 FBXO32 FCGBP FLNB FRMD6 GABARAP GSTP1 IGKC KPNA2 LGALS4 MAP2K6 MBD4 MLH3 MSH3 MSH4 MUC2 MYC MYL6 MYOG NDRG1 NT5C3B ORC4 PARP12 PARVA PCNA PMS1 PMS2 PSMA1 PTGDS PTPRH RAD23B RAD9A RAPGEFL1 SEC61A1 SELENBP1 SERPINF1 SPERT SQSTM1 STAP2 TRIM23 TRIM29 TXN TXN2 UBOX5 VAMP8 ZC3H11A ZER1
Entrez ID		5378	4292
HPRD ID		02597	00390
Ensembl ID		ENSG00000064933	ENSG00000076242
Uniprot IDs		B4DMF4 P54277	P40692 Q59EG3
PDB IDs		2CS1	3NA3 3RBN
Enriched GO Terms of Interacting Partners?		Meiotic Spindle Midzone Assembly Meiotic Metaphase I Plate Congression Negative Regulation Of Mitotic Recombination Regulation Of Mitotic Recombination Male Meiosis Chromosome Segregation Spindle Midzone Assembly Resolution Of Meiotic Recombination Intermediates Somatic Hypermutation Of Immunoglobulin Genes Somatic Diversification Of Immune Receptors Via Somatic Mutation Double-strand Break Repair Via Nonhomologous End Joining Chromosome Separation Negative Regulation Of DNA Recombination Nuclear-transcribed MRNA Poly(A) Tail Shortening Isotype Switching Metaphase Plate Congression Somatic Recombination Of Immunoglobulin Gene Segments Somatic Diversification Of Immunoglobulins Establishment Of Chromosome Localization Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response Reciprocal Meiotic Recombination B Cell Activation Involved In Immune Response Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Synapsis Mismatch Repair Homologous Chromosome Segregation Male Meiosis Immunoglobulin Production Regulation Of DNA Recombination Oogenesis MRNA 3'-end Processing Meiotic Chromosome Segregation Spindle Assembly Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of DNA Metabolic Process RNA 3'-end Processing Meiosis I Female Gamete Generation Spindle Organization Nuclear-transcribed MRNA Catabolic Process Double-strand Break Repair Leukocyte Activation Involved In Immune Response B Cell Activation MRNA Catabolic Process Meiotic Nuclear Division Immunoglobulin Mediated Immune Response B Cell Mediated Immunity RNA Catabolic Process Intrinsic Apoptotic Signaling Pathway Meiotic Cell Cycle Chromosome Segregation	Cellular Response To Stress Cellular Response To DNA Damage Stimulus Cellular Response To Stimulus Response To Stimulus Mismatch Repair Response To Stress DNA Metabolic Process DNA Catabolic Process DNA Recombination Negative Regulation Of Cell Cycle DNA Repair Cell Cycle Cell Cycle Process Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Response To Organic Substance DNA Damage Checkpoint Mitotic DNA Damage Checkpoint Mucus Secretion Regulation Of Cell Cycle Mitotic DNA Integrity Checkpoint Nitrogen Compound Metabolic Process Cellular Response To Organic Substance Apoptotic Process Programmed Cell Death Nucleic Acid Phosphodiester Bond Hydrolysis Cell Death Death Response To Abiotic Stimulus Cell Cycle Checkpoint Apoptotic Signaling Pathway Nucleobase-containing Compound Metabolic Process Cellular Response To Dexamethasone Stimulus Metabolic Process Regulation Of Cellular Protein Metabolic Process Response To Dexamethasone Homeostatic Process Mitotic Cell Cycle Checkpoint Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Catabolic Process, Exonucleolytic Somatic Recombination Of Immunoglobulin Gene Segments G2 DNA Damage Checkpoint DNA Catabolic Process, Endonucleolytic Regulation Of Apoptotic DNA Fragmentation Somatic Diversification Of Immunoglobulins Reciprocal Meiotic Recombination Anatomical Structure Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Actin-mediated Cell Contraction
Tagcloud ?		abnormally angiogenesis antiapoptotic carcinomas colon division enhances immunoreaction immunostaining inactivated inactivation intensity labeled mismatch mlh1 mmr mmrp msh2 msh6 pms2 polyp polyps powerful predominantly rarely repair section suppress survivin	9p24 actionable arid1a atlas barr bystander cd274 cdkn2a classifier comes comprises cpg ebv enrollment epstein fail gastrogenus genomically harbor innocent instability intimately l2 lytic microsatellite msi noncoding pdcd1lg2 qualify
Tagcloud (Difference) ?		abnormally angiogenesis antiapoptotic carcinomas colon division enhances immunoreaction immunostaining inactivated inactivation intensity labeled mismatch mmr mmrp msh2 msh6 pms2 polyp polyps powerful predominantly rarely repair section suppress survivin	9p24 actionable arid1a atlas barr bystander cd274 cdkn2a classifier comes comprises cpg ebv enrollment epstein fail gastrogenus genomically harbor innocent instability intimately l2 lytic microsatellite msi noncoding pdcd1lg2 qualify
Tagcloud (Intersection) ?		mlh1