PMS1 and DYNLT3

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		PMS1	DYNLT3
Name		PMS1 homolog 1, mismatch repair system component	dynein light chain Tctex-type 3
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Mismatch Repair Complex MutLalpha Complex	Chromosome, Centromeric Region Kinetochore Nucleus Chromosome Cytoplasm Cytoskeleton Cytoplasmic Dynein Complex Microtubule Dynein Complex Mitotic Spindle Astral Microtubule
	Molecular Function	DNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Enzyme Binding Mismatched DNA Binding ATP-dependent DNA Damage Sensor Activity	Protein Binding Identical Protein Binding Dynein Intermediate Chain Binding
	Biological Process	DNA Repair Mismatch Repair DNA Damage Response Response To Xenobiotic Stimulus	Microtubule-based Movement Regulation Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Cell Division
GWAS		Cerebral amyloid angiopathy x sex interaction in Alzheimer’s disease ( 34020725 ) Ferritin levels ( 25162662 ) Iron status biomarkers (ferritin levels) ( 28334935 ) Lung cancer (SNP x SNP interaction) ( 24325914 ) Obesity-related traits ( 23251661 ) Subcutaneous adipose tissue ( 22589738 )	No GWAS studies recorded
Novel Interactors		None recorded	4 novel interactors: CYBB FOS IFITM1 UIMC1
Interacting Genes		4 interacting genes: CDC42 DYNLT3 MLH1 RNF10	11 interacting genes: C2orf15 CCL28 CD5 DYNC1I1 DYNC1I2 NIF3L1 PMS1 PVR TESC VDAC1 ZC3H14
Entrez ID		5378	6990
HPRD ID		02597	02249
Ensembl ID		ENSG00000064933	ENSG00000165169
Uniprot IDs		B4DIH7 B7ZAA0 E9PC40 I6L9H5 P54277 Q3BDU3 Q5XG96	P51808
PDB IDs		2CS1	Not available
GO Terms Enriched among Interactors		Apolipoprotein A-I Receptor Binding Endothelin Receptor Signaling Pathway Involved In Heart Process Neuropilin Signaling Pathway GBD Domain Binding Storage Vacuole Microtubule-based Process Meiotic Spindle Midzone Assembly Meiotic Metaphase Chromosome Alignment Guanine/thymine Mispair Binding Male Meiosis Chromosome Segregation Homologous Chromosome Segregation MutLalpha Complex Female Meiosis Chromosome Segregation Chiasma Late Recombination Nodule Mismatch Repair Complex Meiotic Metaphase I Homologous Chromosome Alignment Negative Regulation Of Mitotic Recombination Mitotic Spindle Astral Microtubule Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Positive Regulation Of Pinocytosis G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Positive Regulation Of Isotype Switching To IgA Isotypes MutSalpha Complex Binding Regulation Of Mitotic Recombination Establishment Of Golgi Localization Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Negative Regulation Of Schwann Cell Proliferation Leading Edge Membrane Thioesterase Binding Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Neuron Fate Determination Golgi Transport Complex Positive Regulation Of Cell Cycle Telomere Localization Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Activity Mismatched DNA Binding Positive Regulation Of Isotype Switching To IgG Isotypes Positive Regulation Of Pseudopodium Assembly Endothelin Receptor Signaling Pathway Microtubule-based Movement Somatic Hypermutation Of Immunoglobulin Genes Spindle Midzone Assembly Golgi Localization Meiotic Chromosome Segregation	Dynein Light Chain Binding Dynein Heavy Chain Binding Cytoplasmic Dynein Complex