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MDM2 and TRIM27
Number of citations of the paper that reports this interaction (PubMedID
20972456
)
43
Data Source:
BioGRID
(enzymatic study)
MDM2
TRIM27
Description
MDM2 proto-oncogene
tripartite motif containing 27
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Plasma Membrane
Postsynaptic Density
Nuclear Body
Transcription Repressor Complex
Endocytic Vesicle Membrane
Protein-containing Complex
Centriolar Satellite
Glutamatergic Synapse
Fibrillar Center
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Mitochondrion
Endosome
Early Endosome
Cytosol
PML Body
Retromer Complex
Nuclear Membrane
Molecular Function
P53 Binding
Ubiquitin-protein Transferase Activity
Protein Binding
5S RRNA Binding
Zinc Ion Binding
Transferase Activity
Ligase Activity
SUMO Transferase Activity
Enzyme Binding
Protein Domain Specific Binding
Ubiquitin Protein Ligase Binding
Receptor Serine/threonine Kinase Binding
Identical Protein Binding
Peroxisome Proliferator Activated Receptor Binding
Ribonucleoprotein Complex Binding
Ubiquitin Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
NEDD8 Ligase Activity
Disordered Domain Specific Binding
Nucleic Acid Binding
DNA Binding
Transcription Coactivator Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Transferase Activity
SUMO Transferase Activity
Identical Protein Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Phosphatidylinositol 3-kinase Inhibitor Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Protein Polyubiquitination
Blood Vessel Development
Blood Vessel Remodeling
Regulation Of Heart Rate
Heart Valve Development
Atrioventricular Valve Morphogenesis
Endocardial Cushion Morphogenesis
Ventricular Septum Development
Atrial Septum Development
Ubiquitin-dependent Protein Catabolic Process
Apoptotic Process
Traversing Start Control Point Of Mitotic Cell Cycle
Heart Development
Positive Regulation Of Cell Population Proliferation
Response To Xenobiotic Stimulus
Response To Toxic Substance
Response To Iron Ion
Regulation Of Gene Expression
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Negative Regulation Of Protein Processing
Negative Regulation Of Neuron Projection Development
Protein Ubiquitination
Protein Sumoylation
DNA Damage Response, Signal Transduction By P53 Class Mediator
Protein Destabilization
Response To Magnesium Ion
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Protein Localization To Nucleus
Regulation Of Protein Catabolic Process
Response To Cocaine
Negative Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Protein-containing Complex Organization
Establishment Of Protein Localization
Response To Ether
Positive Regulation Of Cell Cycle
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of Mitotic Cell Cycle
Response To Antibiotic
Positive Regulation Of Protein Export From Nucleus
Response To Steroid Hormone
Positive Regulation Of Muscle Cell Differentiation
Proteolysis Involved In Protein Catabolic Process
Regulation Of Cell Cycle
Protein Autoubiquitination
Cardiac Septum Morphogenesis
Protein-containing Complex Assembly
Regulation Of Biological Quality
Cellular Response To Hydrogen Peroxide
Cellular Response To Antibiotic
Cellular Response To Vitamin B1
Cellular Response To Alkaloid
Cellular Response To Growth Factor Stimulus
Cellular Response To Peptide Hormone Stimulus
Cellular Response To Estrogen Stimulus
Cellular Response To Hypoxia
Cellular Response To Gamma Radiation
Cellular Response To UV-C
Signal Transduction By P53 Class Mediator
Fibroblast Activation
Cellular Response To Actinomycin D
Regulation Of Postsynaptic Neurotransmitter Receptor Internalization
Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission
Negative Regulation Of Signal Transduction By P53 Class Mediator
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Response To Formaldehyde
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Amyloid Fibril Formation
Response To Water-immersion Restraint Stress
Negative Regulation Of Apoptotic Signaling Pathway
Negative Regulation Of Transcription By RNA Polymerase II
Spermatogenesis
Negative Regulation Of Autophagy
Positive Regulation Of Autophagy
Protein Ubiquitination
Protein Sumoylation
Negative Regulation Of Type I Interferon Production
Positive Regulation Of Type I Interferon Production
Negative Regulation Of Viral Transcription
Arp2/3 Complex-mediated Actin Nucleation
Retrograde Transport, Endosome To Golgi
Suppression Of Viral Release By Host
Innate Immune Response
Negative Regulation Of Gene Expression, Epigenetic
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Actin Nucleation
Protein K63-linked Ubiquitination
Pathways
AKT phosphorylates targets in the cytosol
Oxidative Stress Induced Senescence
Oncogene Induced Senescence
SUMOylation of transcription factors
SUMOylation of ubiquitinylation proteins
Trafficking of AMPA receptors
Constitutive Signaling by AKT1 E17K in Cancer
Ub-specific processing proteases
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Degradation
Regulation of TP53 Activity through Methylation
Stabilization of p53
Regulation of RUNX3 expression and activity
Signaling by ALK fusions and activated point mutants
Degradation of CDH1
NPAS4 regulates expression of target genes
SUMOylation of ubiquitinylation proteins
Regulation of PTEN stability and activity
Suppression of apoptosis
Drugs
Zinc
Cis-[4,5-Bis-(4-Bromophenyl)-2-(2-Ethoxy-4-Methoxyphenyl)-4,5-Dihydroimidazol-1-Yl]-[4-(2-Hydroxyethyl)Piperazin-1-Yl]Methanone
Cis-[4,5-Bis-(4-Chlorophenyl)-2-(2-Isopropoxy-4-Methoxyphenyl)-4,5-Dihyd Roimidazol-1-Yl]-Piperazin-1-Yl-Methanone
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Diseases
Penile cancer
Alveolar rhabdomyosarcoma
Choriocarcinoma
Osteosarcoma
Glioma
GWAS
Pneumoconiosis in silica exposure (
24986923
)
Red blood cell count (
32888494
)
Alopecia areata (
25608926
)
Asthma (
31619474
32296059
29273806
)
Asthma and major depressive disorder (
31619474
)
Autism spectrum disorder or schizophrenia (
28540026
)
Body size at age 10 (
32376654
)
Brain morphology (MOSTest) (
32665545
)
Childhood and early adolescence aggressive behavior (
26087016
)
Daytime sleep phenotypes (
27126917
)
Estimated glomerular filtration rate in diabetes (
31451708
)
Experiencing mood swings (
29500382
)
Feeling miserable (
29500382
)
Fish- and plant-related diet (
32066663
)
General risk tolerance (MTAG) (
30643258
)
Hand grip strength (
29691431
)
Heel bone mineral density (
30598549
)
Hemoglobin levels (
32327693
)
Liver iron content (
34128465
)
Lung cancer in ever smokers (
28604730
)
Neurociticism (
29500382
)
Platelet aggregation (
20526338
)
Pre-treatment viral load in HIV-1 infection (
31219150
)
Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) (
26651848
)
Schizophrenia (
30285260
)
Social communication problems (
24047820
)
Subcortical volume (MOSTest) (
32665545
)
Triglyceride levels (
32203549
)
Interacting Genes
271 interacting genes:
ABL1
ABL2
ADRB2
AKAP5
AKT1
ANKRD17
APEX1
APOB
APP
AR
ARRB1
ARRB2
ATF3
ATF4
ATM
ATP2A2
ATRX
AURKA
BAIAP2L1
BRINP1
BTK
BTRC
CANX
CASP2
CASP3
CCAR1
CCDC3
CCNG1
CDC34
CDKN2A
CHEK2
CLSTN1
CLU
COPS5
CREBBP
CSNK2A1
CSNK2A2
CSNK2B
CTBP2
CWC25
DAPK1
DAPK3
DAXX
DDX24
DDX42
DHFR
DLG4
DNAJB4
DYRK2
EGLN3
EID1
EP300
ESR1
EZR
F3
FBXO31
FHL2
FKBP1A
FOS
FOXO1
FOXO3
FOXP3
G3BP2
GADD45A
GCAT
GLIS2
GNL3
GORAB
GRK2
GSK3B
GTF2E2
GYS2
H2BC21
H3-4
HCK
HDAC1
HEY1
HIF1A
HIPK2
HLA-DMB
HMGA2
HMGN1
HNRNPK
HSP90B1
IER3
IGF1R
IL33
IRF1
IRF2
JMY
JUN
JUND
KAT2B
KAT5
KIAA1671
KPNA1
LMO7
MAGEA2
MAGEC2
MAP1LC3A
MAP2
MAPKAPK2
MAPT
MDM4
MED1
MKRN3
MS4A1
MTBP
MYC
MYD88
MYDGF
NACA
NAT10
NCL
NDUFS1
NGFR
NOLC1
NOTCH1
NPIPB3
NPM1
NR1I2
NR3C1
NRON
NUCKS1
NUMB
OVOL2
PADI4
PAK6
PBX1
PBXIP1
PDCD1
PDE4D
PDIA3
PDLIM7
PDS5A
PGAM2
PHF7
PHLDB3
PIAS1
PJA1
PKM
PLK1
PML
POLE
POT1
PPIB
PPM1D
PPP1R10
PRDM2
PRKN
PSMA3
PSMC5
PSMD10
PSMD4
PSME3
PTK2
RAB8A
RAD23A
RALY
RANBP1
RANBP2
RARA
RASSF1
RB1
RBBP6
RBM10
RBM38
RESF1
RIDA
RLIM
RNF10
RNF115
RNF126
RNF8
RPL11
RPL22
RPL26
RPL36A
RPL4
RPL5
RPS23
RPS3
RPS5
RRM2B
RRP1
RSL1D1
RUVBL2
RYBP
RYR2
S100A1
S100A2
S100A4
S100A6
S100B
SDHC
SESN2
SET
SETD7
SETDB1
SHPK
SIRT2
SIRT3
SMARCA2
SMARCA4
SMARCE1
SMG7
SNCA
SORBS2
SRC
SREK1
SRSF11
SUMO1
TAF1
TBP
TCAP
TFIP11
TOP1
TP53
TP53I3
TP53RK
TP73
TPR
TPT1
TRAF5
TRIB3
TRIM13
TRIM23
TRIM27
TRIM4
TRIM9
TSG101
UBB
UBC
UBE2A
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2G2
UBE2H
UBE2I
UBE2J2
UBE2K
UBE2L3
UBE2N
UBE2O
UBE2Q1
UBE2Q2
UBE2R2
UBE2S
UBE2U
UBE2Z
UBE3A
UBQLN4
UBTF
USP15
USP2
USP7
VCP
VEGFA
WRN
WT1
XBP1
XIAP
XPC
YY1AP1
ZNF133
ZNF420
353 interacting genes:
ABCA1
ABCF3
ABHD17A
ACSF3
AEN
AIRIM
AMMECR1
AMOTL2
AP1M1
ARHGEF3
ARHGEF5
ARID5A
ARIH2
ARMC7
ARNT2
ARPIN
ATOSA
ATOSB
ATPAF2
ATXN7
AXIN1
BABAM1
BAG1
BAG3
BAG5
BEGAIN
BEX2
BMI1
BMP7
BYSL
CAPN7
CARD10
CATSPER1
CBX8
CCDC102B
CCDC185
CCDC187
CCDC198
CCDC87
CCDC92
CCHCR1
CDC20B
CDC23
CDC7
CDK18
CDKL3
CFAP206
CFTR
CHCHD3
CHD4
CHUK
CIMIP4
CKS1B
CLK2
CNNM3
COX5B
CPNE2
CPNE7
CREB5
CSRP2
CWF19L2
DBF4B
DCX
DDX6
DGCR6
DMRT3
DNMT1
DTNB
DTNBP1
EHHADH
EID1
EIF3D
EIF3E
EIF4A3
EIF4E
EIF4E2
ENKD1
EPC1
ERCC3
EXOC8
FAM110A
FAM161A
FAM193B
FAM83A
FAM90A1
FANCM
FARS2
FASTKD5
FBF1
FBXL19
FBXW5
FHL3
FNDC11
FOXB1
FOXC2
FXYD6
GADD45GIP1
GAS2L2
GATAD2B
GCC2-AS1
GEM
GFAP
GFI1B
GFM2
GLYCTK
GNE
GNPDA2
GPANK1
GPKOW
GRB14
GRB2
GSE1
GTF2F1
HAPLN2
HAUS1
HCK
HDAC1
HDAC4
HGS
HIP1R
HNRNPLL
HOXB5
HOXB9
HOXC8
HR
HYCC1
HYCC2
IGFN1
IKBKB
IKBKE
IL16
ILF2
ILK
INO80B
INPP5J
IP6K3
IQCE
IQCN
IQUB
JOSD1
KANSL1
KAT14
KAT5
KCTD15
KCTD9
KIF1A
KIF9
KIFC3
KRT3
KRT75
KRT76
LAGE3
LASP1
LENG1
LGALS14
LINC00526
LINGO1
LMNB2
LMO1
LMO4
LNX1
LONRF1
MAD2L2
MAGEA11
MAGED4B
MAGEF1
MAGOHB
MAPKBP1
MAT2B
MBD4
MCM7
MCOLN1
MDM2
MED21
MEMO1
MIA3
MID2
MOS
MRPL40
MSRB1
MTMR6
MVP
MYO15B
NCK2
NCOA1
NDE1
NEBL
NEDD9
NEIL2
NEK6
NELFE
NIF3L1
NME7
NOTCH2NLA
NR1D2
NTAQ1
NUDT21
OAS1
OGT
OTUB2
P2RX7
PIAS1
PIAS2
PIAS3
PIAS4
PIBF1
PIMREG
PIN1
PLEKHN1
PML
POLE2
POLR1C
POLR3C
POM121
PPID
PPL
PPP1R18
PRAM1
PRKAA1
PRPF18
PRPF31
PRR35
PSMA1
PSMB1
PSMB3
PTPMT1
PTPN23
PUS7L
QARS1
RAB29
RAMAC
RB1
RBM23
RBM41
RBX1
RCOR3
REL
RHPN1
RIBC1
RIN1
RNF213
RNF25
RNF6
RSPH14
RXRB
SCNM1
SDCBP
SH2D4A
SHANK3
SIAH1
SIRPA
SLC15A3
SMARCB1
SMARCD1
SMG9
SNRPA
SNRPB2
SORBS3
SPATA2
SPATC1L
SQSTM1
SRSF2
STAMBPL1
STK16
STK25
STK26
SYNGAP1
SYT17
SYT6
TACO1
TBC1D22B
TCEA2
TCEANC
TCHP
THOC1
TLE5
TMSB4X
TMSB4XP6
TNS4
TPM3
TPRKB
TRAF4
TRAF5
TRIM11
TRIM21
TRIM23
TRIM29
TRIM31
TRIM32
TRIM42
TRIM43
TRIM50
TRIM55
TRIM9
TSGA10IP
TSHZ3
TTLL10
TUBGCP4
TUFT1
TXNDC9
UBASH3A
UBC
UBE2A
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2I
UBE2J1
UBE2K
UBE2L6
UBE2N
UBE2O
UBE2T
UBE2U
UBE2W
UBE2Z
UBL5
UCHL3
UCHL5
UHRF2
USE1
USP2
UTP14C
UTP23
VEZF1
VPS25
VPS28
VPS9D1
WT1-AS
XPA
YJU2
ZBTB16
ZC2HC1C
ZFC3H1
ZFHX3
ZFYVE21
ZGPAT
ZMYND19
ZNF250
ZNF384
ZNF414
ZNF417
ZNF446
ZNF572
ZNF580
ZNF581
ZNF587
ZNF688
ZNF79
Entrez ID
4193
5987
HPRD ID
01272
15996
Ensembl ID
ENSG00000135679
ENSG00000204713
Uniprot IDs
A0A0A8KB75
A7UKX7
A7UKX8
A7UKX9
G3XA89
Q00987
Q96DS0
A0A1U9X8R9
P14373
PDB IDs
1RV1
1T4E
1T4F
1YCR
1Z1M
2AXI
2C6A
2C6B
2F1Y
2FOP
2GV2
2HDP
2LZG
2M86
2MPS
2RUH
2VJE
2VJF
3EQS
3G03
3IUX
3IWY
3JZK
3JZR
3JZS
3LBK
3LBL
3LNJ
3LNZ
3MQS
3TJ2
3TPX
3TU1
3V3B
3VBG
3VZV
3W69
4DIJ
4ERE
4ERF
4HBM
4HFZ
4HG7
4JV7
4JV9
4JVE
4JVR
4JWR
4MDN
4MDQ
4OAS
4OBA
4OCC
4ODE
4ODF
4OGN
4OGT
4OGV
4OQ3
4QO4
4QOC
4UD7
4UE1
4UMN
4WT2
4XXB
4ZFI
4ZGK
4ZYC
4ZYF
4ZYI
5AFG
5C5A
5HMH
5HMI
5HMK
5J7F
5J7G
5LAV
5LAW
5LAY
5LAZ
5LN2
5MNJ
5OAI
5OC8
5SWK
5TRF
5UMM
5VK0
5WTS
5XXK
5Z02
5ZXF
6AAW
6GGN
6H22
6HFA
6I29
6I3S
6IM9
6KZU
6Q96
6Q9H
6Q9L
6Q9O
6SQO
6T2D
6T2E
6T2F
6Y4Q
6YR6
7AD0
7AI0
7AI1
7AYE
7BIR
7BIT
7BIV
7BJ0
7BJ6
7BMG
7KJM
7NA1
7NA2
7NA3
7NA4
7NUS
7QDQ
8AEU
8BGU
8EI9
8EIA
8EIB
8EIC
8F0Z
8F10
8F12
8F13
8GCG
8J81
8P0D
8PWC
9GFC
Enriched GO Terms of Interacting Partners
?
Nucleus
Nucleoplasm
Macromolecule Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Regulation Of Primary Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Cellular Response To Stress
Ubiquitin Conjugating Enzyme Activity
Positive Regulation Of Metabolic Process
Negative Regulation Of Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of RNA Metabolic Process
Protein Modification Process
Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Protein Metabolic Process
Regulation Of Programmed Cell Death
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Apoptotic Process
Post-translational Protein Modification
Protein Modification By Small Protein Conjugation
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Protein Metabolic Process
Modification-dependent Protein Catabolic Process
Regulation Of RNA Metabolic Process
Protein Ubiquitination
Regulation Of Signal Transduction
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of DNA-templated Transcription
Proteolysis Involved In Protein Catabolic Process
Positive Regulation Of RNA Biosynthetic Process
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Macromolecule Biosynthetic Process
Macromolecule Catabolic Process
DNA Damage Response
Positive Regulation Of Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Signal Transduction By P53 Class Mediator
Cytosol
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of RNA Metabolic Process
Regulation Of Signaling
Regulation Of Cell Communication
Response To Stress
Protein Binding
Ubiquitin Conjugating Enzyme Activity
Nucleus
Protein Modification By Small Protein Conjugation
Post-translational Protein Modification
Protein Ubiquitination
Protein Polyubiquitination
Nucleoplasm
Protein Modification Process
Modification-dependent Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Ubiquitin-protein Transferase Activity
Macromolecule Metabolic Process
Proteolysis Involved In Protein Catabolic Process
Protein K48-linked Ubiquitination
SUMO Transferase Activity
Macromolecule Catabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Protein K63-linked Ubiquitination
Regulation Of RNA Metabolic Process
Protein Metabolic Process
Ubiquitin Protein Ligase Activity
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Cytoplasm
Ubiquitin Protein Ligase Binding
Protein K6-linked Ubiquitination
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Macromolecule Metabolic Process
Protein Monoubiquitination
Regulation Of Primary Metabolic Process
Proteolysis
Zinc Ion Binding
PML Body
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Cytosol
Regulation Of Gene Expression
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Protein Sumoylation
Transferase Activity
Protein K11-linked Ubiquitination
ATP Binding
Negative Regulation Of Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
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Tagcloud (Intersection)
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