MDM2 and UBE3A

  • Number of citations of the paper that reports this interaction (PMID 11486026)
  • 17
  • Data Source:
  • BioGRID (enzymatic study)

MDM2

UBE3A

Gene Name MDM2 proto-oncogene, E3 ubiquitin protein ligase ubiquitin protein ligase E3A
Image
Gene Ontology Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions 185 interactors: ABL1 ADRB2 ADRBK1 AKT1 ANKRD17 APEX1 APP AR ARRB2 ATF3 ATF4 ATM ATP2A2 AURKA BAIAP2L1 BRINP1 BTRC CANX CASP2 CASP3 CCAR1 CCNG1 CDH1 CDKN2A CHEK2 CLSTN1 CLU COPS5 CREBBP CTBP2 CWC25 DAPK1 DAPK3 DAXX DHFR DLG4 DNAJB4 DYRK2 E2F1 EID1 EP300 ESR1 EZR FOXO1 G3BP2 GADD45A GCAT GLTSCR2 GNL3 GORAB GSK3B GTF2E1 GTF2E2 HDAC1 HIF1A HIPK2 HIST2H2BE HIST3H3 HLA-DMB HRSP12 HSP90B1 IGF1R IRF1 IRF2 JMY JUN JUND KAT2B KAT5 LMO7 MDM4 MED1 MKRN3 MS4A1 MTBP MYD88 MYDGF NACA NCL NOTCH1 NPM1 NR3C1 NUMB PAK6 PBX1 PDE4D PDIA3 PDLIM7 PGAM2 PHF7 PIAS1 PJA1 PKM PLK1 PML POLE POT1 PPIB PPM1D PSMA3 PSMC5 PSMD10 PSMD4 PSME3 PTK2 RAB8A RABL6 RAD23A RANBP1 RANBP2 RASSF1 RB1 RBM38 RCHY1 RNF10 RNF126 RNF8 RPL11 RPL26 RPL5 RPS23 RPS27A RPS3 RPS7 RRM2B RUVBL2 RYBP RYR2 S100A1 S100A2 S100A4 S100A6 S100B SDHC SENP3 SESN2 SET SETDB1 SHPK SMARCA2 SMARCA4 SMARCE1 SORBS2 SREK1 SRSF11 SUMO1 TAF1 TBP TCAP TERT TOP1 TP53 TP73 TPR TPT1 TRAF5 TRIM23 TRIM27 TRIM4 TRIM9 TSC22D3 TSG101 UBB UBE2A UBE2D1 UBE2D2 UBE2D3 UBE2E2 UBE2E3 UBE2G2 UBE2I UBE2K UBE2L3 UBE2M UBE2U UBE2Z UBE3A UBQLN4 UBTF USP2 USP7 WT1 XPC YY1AP1 ZNF133 80 interactors: ADRM1 AFG3L1P AFTPH AHSP ANXA1 APP AR ARC ASAP3 ATG9A BARD1 BLK BPY2 BPY2B BPY2C BRCA1 C11orf49 CDKN1B CEBPZ DLG1 EAPP EID1 EIF4G1 HBA1 HPCAL4 HSPA4 JADE1 KLHL38 LCK MAGEA8 MCM7 MDM2 MEOX2 NDUFA13 NELFCD NOMO2 PARVA PDE1B PGR PML POLE4 PRDX1 PSAP PSMC3 PSMD4 RAD23A RAD23B RARA RMI1 RNF2 SACS SCAMP1 SCRIB SGK223 SHBG SMAD9 SOD1 SUMO3 TAT TBC1D14 TCF19 TP53 TRIM65 TSC2 TTC3 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2G1 UBE2G2 UBE2L3 UBE2L6 UBQLN2 UCHL5 YOD1 YWHAE YWHAZ
Entrez ID 4193 7337
HPRD ID 01272 03375
Ensembl ID ENSG00000135679 ENSG00000114062
Uniprot IDs A7UKX7 A7UKX8 A7UKX9 G3XA89 Q00987 Q96DS0 Q05086 Q9BUI6 Q9H2G0
PDB IDs 1RV1 1T4E 1T4F 1YCR 1Z1M 2AXI 2C6A 2C6B 2F1Y 2FOP 2GV2 2HDP 2LZG 2M86 2VJE 2VJF 3EQS 3G03 3IUX 3IWY 3JZK 3JZR 3JZS 3LBK 3LBL 3LNJ 3LNZ 3TJ2 3TPX 3TU1 3V3B 3VBG 3VZV 3W69 4DIJ 4ERE 4ERF 4HBM 4HFZ 4JV7 4JV9 4JVE 4JVR 4JWR 1C4Z 1D5F 1EQX 2KR1 4GIZ
Enriched GO Terms of Interacting Partners?
Tagcloud ?
abundance  bound  cbp  coactivator  destabilizer  directed  e1a  endogenous  h1  implies  implying  interactions  intimately  naturally  normally  occurring  operate  overproducing  p300  p53  regard  serves  stability  stabilizing  steps  taken  translates  turnover  underscored 
2h5  accompanies  anova  dynactin  gadd45a  gtf2h5  invites  keuls  macaques  malfunctioning  nbn1  ndd  ndds  newman  ovx  perimenopausal  presenilin1  proteosome  psen1  rad23a  raphe  scna  serotonin  speculation  subserving  symptomology  ube2d3  ubea5  ubiquinase 
Tagcloud (Difference) ?
abundance  bound  cbp  coactivator  destabilizer  directed  e1a  endogenous  h1  implies  implying  interactions  intimately  naturally  normally  occurring  operate  overproducing  p300  p53  regard  serves  stability  stabilizing  steps  taken  translates  turnover  underscored 
2h5  accompanies  anova  dynactin  gadd45a  gtf2h5  invites  keuls  macaques  malfunctioning  nbn1  ndd  ndds  newman  ovx  perimenopausal  presenilin1  proteosome  psen1  rad23a  raphe  scna  serotonin  speculation  subserving  symptomology  ube2d3  ubea5  ubiquinase 
Tagcloud (Intersection) ?