MDM2 and PSME3

Number of citations of the paper that reports this interaction (PMID 18309296)
33

Data Source:
HPRD (in vitro)

		MDM2	PSME3
Gene Name		MDM2 proto-oncogene, E3 ubiquitin protein ligase	proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Nuclear Body Endocytic Vesicle Membrane Protein Complex Synapse	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Cytosol Proteasome Activator Complex Membrane
	Molecular Function	P53 Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Enzyme Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Peroxisome Proliferator Activated Receptor Binding Ubiquitin Protein Ligase Activity Scaffold Protein Binding	P53 Binding Protein Binding Endopeptidase Activator Activity MDM2/MDM4 Family Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Protein Complex Assembly DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Traversing Start Control Point Of Mitotic Cell Cycle Epidermal Growth Factor Receptor Signaling Pathway Synaptic Transmission Positive Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Response To Carbohydrate Response To Iron Ion Positive Regulation Of Gene Expression Viral Process Protein Ubiquitination Peptidyl-lysine Modification Protein Destabilization Response To Magnesium Ion Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Localization To Nucleus Fc-epsilon Receptor Signaling Pathway Regulation Of Protein Catabolic Process Response To Cocaine Response To Drug Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Morphine Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Innate Immune Response Establishment Of Protein Localization Response To Ether Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Mitotic Cell Cycle Response To Antibiotic Positive Regulation Of Protein Export From Nucleus Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Cellular Response To Hydrogen Peroxide Negative Regulation Of Cell Cycle Arrest Cellular Response To Acid Chemical Cellular Response To Antibiotic Cellular Response To Vitamin B1 Cellular Response To Alkaloid Cellular Response To Peptide Hormone Stimulus Cellular Response To Estrogen Stimulus Cellular Response To Hypoxia Cellular Response To UV-C	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Mitotic Cell Cycle Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Regulation Of Cellular Amino Acid Metabolic Process Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Gene Expression Positive Regulation Of Endopeptidase Activity Viral Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Nitrogen Compound Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Small Molecule Metabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease Cellular Senescence p53-Dependent G1/S DNA damage checkpoint AKT phosphorylates targets in the cytosol Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade Stabilization of p53 Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Signaling by PDGF DAP12 interactions GAB1 signalosome Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling PI3K/AKT Signaling in Cancer Adaptive Immune System Transmission across Chemical Synapses PIP3 activates AKT signaling Oncogene Induced Senescence p53-Dependent G1 DNA Damage Response PI3K events in ERBB2 signaling Downstream signaling of activated FGFR G1/S DNA Damage Checkpoints Innate Immune System Signalling by NGF Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Trafficking of AMPA receptors Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR Oxidative Stress Induced Senescence Cell Cycle Checkpoints Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity	Hedgehog 'off' state misspliced GSK3beta mutants stabilize beta-catenin Hh ligand biogenesis disease T41 mutants of beta-catenin aren't phosphorylated Downstream signaling events of B Cell Receptor (BCR) Degradation of beta-catenin by the destruction complex Stabilization of p53 S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling Removal of licensing factors from origins Switching of origins to a post-replicative state Mitotic G1-G1/S phases Regulation of mRNA stability by proteins that bind AU-rich elements misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling DNA Replication Pre-Initiation S45 mutants of beta-catenin aren't phosphorylated APC/C:Cdc20 mediated degradation of mitotic proteins Regulation of APC/C activators between G1/S and early anaphase SCF(Skp2)-mediated degradation of p27/p21 deletions in the AMER1 gene destabilize the destruction complex Autodegradation of the E3 ubiquitin ligase COP1 AMER1 mutants destabilize the destruction complex Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint PCP/CE pathway Adaptive Immune System CDK-mediated phosphorylation and removal of Cdc6 Hedgehog ligand biogenesis APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids HIV Infection Ubiquitin-dependent degradation of Cyclin D APC truncation mutants have impaired AXIN binding Assembly of the pre-replicative complex Autodegradation of Cdh1 by Cdh1:APC/C p53-Dependent G1 DNA Damage Response S37 mutants of beta-catenin aren't phosphorylated XAV939 inhibits tankyrase, stabilizing AXIN p53-Independent DNA Damage Response p53-Independent G1/S DNA damage checkpoint G1/S DNA Damage Checkpoints Vpu mediated degradation of CD4 Synthesis of DNA M/G1 Transition Ubiquitin-dependent degradation of Cyclin D1 TCF dependent signaling in response to WNT SCF-beta-TrCP mediated degradation of Emi1 degradation of AXIN Signaling by Hedgehog Regulation of mitotic cell cycle Degradation of GLI1 by the proteasome degradation of DVL Cell Cycle Checkpoints Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Regulation of Apoptosis Degradation of GLI2 by the proteasome Signaling by the B Cell Receptor (BCR) Vif-mediated degradation of APOBEC3G Ubiquitin Mediated Degradation of Phosphorylated Cdc25A p53-Dependent G1/S DNA damage checkpoint truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Signaling by Wnt Cyclin E associated events during G1/S transition APC/C:Cdc20 mediated degradation of Securin AUF1 (hnRNP D0) destabilizes mRNA CDK-mediated phosphorylation and removal of Cdc6 RNF mutants show enhanced WNT signaling and proliferation G1/S Transition truncations of AMER1 destabilize the destruction complex Processing-defective Hh variants abrogate ligand secretion Host Interactions of HIV factors phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex Regulation of activated PAK-2p34 by proteasome mediated degradation AXIN missense mutants destabilize the destruction complex S Phase APC/C-mediated degradation of cell cycle proteins Cyclin A:Cdk2-associated events at S phase entry SCF(Skp2)-mediated degradation of p27/p21 Mitotic Metaphase and Anaphase Regulation of ornithine decarboxylase (ODC) Antigen processing: Ubiquitination & Proteasome degradation Orc1 removal from chromatin Mitotic Anaphase M Phase APC truncation mutants are not K63 polyubiquitinated Metabolism of amino acids and derivatives Hedgehog 'on' state Programmed Cell Death Class I MHC mediated antigen processing & presentation Regulation of DNA replication Cell Cycle, Mitotic beta-catenin independent WNT signaling Orc1 removal from chromatin Activation of NF-kappaB in B cells Asymmetric localization of PCP proteins deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Cross-presentation of soluble exogenous antigens (endosomes) Antigen processing-Cross presentation CDT1 association with the CDC6:ORC:origin complex ER-Phagosome pathway
Drugs		Cis-[4,5-Bis-(4-Bromophenyl)-2-(2-Ethoxy-4-Methoxyphenyl)-4,5-Dihydroimidazol-1-Yl]-[4-(2-Hydroxyethyl)Piperazin-1-Yl]Methanone Cis-[4,5-Bis-(4-Chlorophenyl)-2-(2-Isopropoxy-4-Methoxyphenyl)-4,5-Dihyd Roimidazol-1-Yl]-Piperazin-1-Yl-Methanone
Diseases
GWAS
Protein-Protein Interactions		185 interactors: ABL1 ADRB2 ADRBK1 AKT1 ANKRD17 APEX1 APP AR ARRB2 ATF3 ATF4 ATM ATP2A2 AURKA BAIAP2L1 BRINP1 BTRC CANX CASP2 CASP3 CCAR1 CCNG1 CDH1 CDKN2A CHEK2 CLSTN1 CLU COPS5 CREBBP CTBP2 CWC25 DAPK1 DAPK3 DAXX DHFR DLG4 DNAJB4 DYRK2 E2F1 EID1 EP300 ESR1 EZR FOXO1 G3BP2 GADD45A GCAT GLTSCR2 GNL3 GORAB GSK3B GTF2E1 GTF2E2 HDAC1 HIF1A HIPK2 HIST2H2BE HIST3H3 HLA-DMB HRSP12 HSP90B1 IGF1R IRF1 IRF2 JMY JUN JUND KAT2B KAT5 LMO7 MDM4 MED1 MKRN3 MS4A1 MTBP MYD88 MYDGF NACA NCL NOTCH1 NPM1 NR3C1 NUMB PAK6 PBX1 PDE4D PDIA3 PDLIM7 PGAM2 PHF7 PIAS1 PJA1 PKM PLK1 PML POLE POT1 PPIB PPM1D PSMA3 PSMC5 PSMD10 PSMD4 PSME3 PTK2 RAB8A RABL6 RAD23A RANBP1 RANBP2 RASSF1 RB1 RBM38 RCHY1 RNF10 RNF126 RNF8 RPL11 RPL26 RPL5 RPS23 RPS27A RPS3 RPS7 RRM2B RUVBL2 RYBP RYR2 S100A1 S100A2 S100A4 S100A6 S100B SDHC SENP3 SESN2 SET SETDB1 SHPK SMARCA2 SMARCA4 SMARCE1 SORBS2 SREK1 SRSF11 SUMO1 TAF1 TBP TCAP TERT TOP1 TP53 TP73 TPR TPT1 TRAF5 TRIM23 TRIM27 TRIM4 TRIM9 TSC22D3 TSG101 UBB UBE2A UBE2D1 UBE2D2 UBE2D3 UBE2E2 UBE2E3 UBE2G2 UBE2I UBE2K UBE2L3 UBE2M UBE2U UBE2Z UBE3A UBQLN4 UBTF USP2 USP7 WT1 XPC YY1AP1 ZNF133	35 interactors: ADAP1 AICDA ATN1 ATP5B BBS2 CASP3 CASP6 CASP7 COIL CREBBP DIP2A DTNBP1 EAF1 FBXO7 FXR2 HSPA5 ITPKB KANSL1 MDM2 NCOA3 NUDT18 PFDN5 PRKAB2 PRR13 SERF2 SIRT1 SMURF1 SPG7 TBXA2R TNFAIP8L1 TP53 TXN2 WDR25 YWHAQ ZCCHC10
Entrez ID		4193	10197
HPRD ID		01272	05500
Ensembl ID		ENSG00000135679	ENSG00000131467
Uniprot IDs		A7UKX7 A7UKX8 A7UKX9 G3XA89 Q00987 Q96DS0	P61289 Q6MZZ1
PDB IDs		1RV1 1T4E 1T4F 1YCR 1Z1M 2AXI 2C6A 2C6B 2F1Y 2FOP 2GV2 2HDP 2LZG 2M86 2VJE 2VJF 3EQS 3G03 3IUX 3IWY 3JZK 3JZR 3JZS 3LBK 3LBL 3LNJ 3LNZ 3TJ2 3TPX 3TU1 3V3B 3VBG 3VZV 3W69 4DIJ 4ERE 4ERF 4HBM 4HFZ 4JV7 4JV9 4JVE 4JVR 4JWR
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Cycle Negative Regulation Of Cellular Metabolic Process Cellular Response To Stress Viral Process Cell Cycle Process Cell Cycle Regulation Of Mitotic Cell Cycle Positive Regulation Of Cellular Metabolic Process Cell Death Death Programmed Cell Death Protein Modification By Small Protein Conjugation Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Positive Regulation Of Metabolic Process Response To Stress Regulation Of Protein Metabolic Process Apoptotic Process Regulation Of Apoptotic Process Cellular Response To DNA Damage Stimulus Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Cell Death Regulation Of Cell Cycle Phase Transition Protein Ubiquitination Regulation Of Metabolic Process Negative Regulation Of Gene Expression Regulation Of Protein Catabolic Process Cellular Macromolecule Catabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of RNA Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Transcription, DNA-templated Protein Polyubiquitination Positive Regulation Of Cell Cycle Cellular Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Mitotic Cell Cycle Positive Regulation Of Cell Cycle Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process	Response To Nutrient Levels Response To Extracellular Stimulus Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Metabolic Process Cellular Response To Nutrient Levels Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Gene Expression Negative Regulation Of Helicase Activity Cellular Response To Extracellular Stimulus Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Mitochondrion Organization Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Oxygen Levels Peptidyl-lysine Acetylation Peptidyl-lysine Modification Positive Regulation Of Cell Aging Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Signal Transduction Apoptotic Process Protein Acetylation Glial Cell Apoptotic Process Programmed Cell Death Regulation Of Gene Expression Anatomical Structure Development Response To Hypoxia Developmental Process Cell Death Death Mitochondrial Transport Response To Organic Substance Regulation Of Cellular Process Neuron Apoptotic Process Response To Antibiotic Regulation Of Signaling Cellular Component Disassembly Involved In Execution Phase Of Apoptosis ER Overload Response Apoptotic Signaling Pathway Neuron Death Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Organic Substance Intracellular Transport Proteolysis Multicellular Organismal Development Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Execution Phase Of Apoptosis Cellular Response To Oxidative Stress
Tagcloud ?		abundance bound cbp coactivator destabilizer directed e1a endogenous h1 implies implying interactions intimately naturally normally occurring operate overproducing p300 p53 regard serves stability stabilizing steps taken translates turnover underscored	11sgamma amplification balance basal bioinformatics biotinylated called cdna ends export feedback immunoprecipitation ligase loop luciferase maintains negatively p53 pa28gamma precipitation promoter promotes promoting race reggamma regulates rlm start utilizing
Tagcloud (Difference) ?		abundance bound cbp coactivator destabilizer directed e1a endogenous h1 implies implying interactions intimately naturally normally occurring operate overproducing p300 regard serves stability stabilizing steps taken translates turnover underscored	11sgamma amplification balance basal bioinformatics biotinylated called cdna ends export feedback immunoprecipitation ligase loop luciferase maintains negatively pa28gamma precipitation promoter promotes promoting race reggamma regulates rlm start utilizing
Tagcloud (Intersection) ?		p53