MDM2 and ATM

  • Number of citations of the paper that reports this interaction (PMID 11331603)
  • 134
  • Data Source:
  • BioGRID (enzymatic study)
  • HPRD (in vitro, in vivo)

MDM2

ATM

Gene Name MDM2 proto-oncogene, E3 ubiquitin protein ligase ATM serine/threonine kinase
Image No pdb structure
Gene Ontology Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions 185 interactors: ABL1 ADRB2 ADRBK1 AKT1 ANKRD17 APEX1 APP AR ARRB2 ATF3 ATF4 ATM ATP2A2 AURKA BAIAP2L1 BRINP1 BTRC CANX CASP2 CASP3 CCAR1 CCNG1 CDH1 CDKN2A CHEK2 CLSTN1 CLU COPS5 CREBBP CTBP2 CWC25 DAPK1 DAPK3 DAXX DHFR DLG4 DNAJB4 DYRK2 E2F1 EID1 EP300 ESR1 EZR FOXO1 G3BP2 GADD45A GCAT GLTSCR2 GNL3 GORAB GSK3B GTF2E1 GTF2E2 HDAC1 HIF1A HIPK2 HIST2H2BE HIST3H3 HLA-DMB HRSP12 HSP90B1 IGF1R IRF1 IRF2 JMY JUN JUND KAT2B KAT5 LMO7 MDM4 MED1 MKRN3 MS4A1 MTBP MYD88 MYDGF NACA NCL NOTCH1 NPM1 NR3C1 NUMB PAK6 PBX1 PDE4D PDIA3 PDLIM7 PGAM2 PHF7 PIAS1 PJA1 PKM PLK1 PML POLE POT1 PPIB PPM1D PSMA3 PSMC5 PSMD10 PSMD4 PSME3 PTK2 RAB8A RABL6 RAD23A RANBP1 RANBP2 RASSF1 RB1 RBM38 RCHY1 RNF10 RNF126 RNF8 RPL11 RPL26 RPL5 RPS23 RPS27A RPS3 RPS7 RRM2B RUVBL2 RYBP RYR2 S100A1 S100A2 S100A4 S100A6 S100B SDHC SENP3 SESN2 SET SETDB1 SHPK SMARCA2 SMARCA4 SMARCE1 SORBS2 SREK1 SRSF11 SUMO1 TAF1 TBP TCAP TERT TOP1 TP53 TP73 TPR TPT1 TRAF5 TRIM23 TRIM27 TRIM4 TRIM9 TSC22D3 TSG101 UBB UBE2A UBE2D1 UBE2D2 UBE2D3 UBE2E2 UBE2E3 UBE2G2 UBE2I UBE2K UBE2L3 UBE2M UBE2U UBE2Z UBE3A UBQLN4 UBTF USP2 USP7 WT1 XPC YY1AP1 ZNF133 76 interactors: AATF ABL1 AP1B1 AP2A2 AP2B1 AP3B2 ATR BCL10 BLM BRCA1 BRCA2 CDC6 CDKN2C CHD4 CHEK1 CHEK2 CREB1 CSNK1D CXXC5 DAXX DCLRE1C DDX1 DYRK2 E2F1 E4F1 EEF1E1 EIF3E EIF4EBP1 EXO1 FANCD2 FOXO3 H2AFX HIF1A KAT5 KAT8 LIG4 MCM2 MDC1 MDM2 MDM4 MRE11A NBN PARP1 PEX5 POLR2A PRKDC PTS RAD17 RAD51 RAD9A RBBP8 RHEB RNF20 RNF40 RPA1 RPA2 SMC1A SOCS1 SPSB1 STK11 TCL1A TELO2 TERF1 TERF2 TIPARP TOP1 TOPBP1 TP53 TP53BP1 TRAF6 TREX1 VPRBP WRN XPA XRCC5 ZEB1
Entrez ID 4193 472
HPRD ID 01272 06347
Ensembl ID ENSG00000135679 ENSG00000149311
Uniprot IDs A7UKX7 A7UKX8 A7UKX9 G3XA89 Q00987 Q96DS0 Q13315
PDB IDs 1RV1 1T4E 1T4F 1YCR 1Z1M 2AXI 2C6A 2C6B 2F1Y 2FOP 2GV2 2HDP 2LZG 2M86 2VJE 2VJF 3EQS 3G03 3IUX 3IWY 3JZK 3JZR 3JZS 3LBK 3LBL 3LNJ 3LNZ 3TJ2 3TPX 3TU1 3V3B 3VBG 3VZV 3W69 4DIJ 4ERE 4ERF 4HBM 4HFZ 4JV7 4JV9 4JVE 4JVR 4JWR
Enriched GO Terms of Interacting Partners?
Tagcloud ?
abundance  bound  cbp  coactivator  destabilizer  directed  e1a  endogenous  h1  implies  implying  interactions  intimately  naturally  normally  occurring  operate  overproducing  p300  p53  regard  serves  stability  stabilizing  steps  taken  translates  turnover  underscored 
absent  alpha  ataxia  basis  cytokines  defective  degradation  fibroblasts  fully  ikappab  immunoprecipitated  induces  ionizing  kappab  mediates  mitogens  nf  oxidants  oxidative  product  radiation  rapid  restores  stimuli  stresses  telangiectasia  tnf  transfected  understood 
Tagcloud (Difference) ?
abundance  bound  cbp  coactivator  destabilizer  directed  e1a  endogenous  h1  implies  implying  interactions  intimately  naturally  normally  occurring  operate  overproducing  p300  p53  regard  serves  stability  stabilizing  steps  taken  translates  turnover  underscored 
absent  alpha  ataxia  basis  cytokines  defective  degradation  fibroblasts  fully  ikappab  immunoprecipitated  induces  ionizing  kappab  mediates  mitogens  nf  oxidants  oxidative  product  radiation  rapid  restores  stimuli  stresses  telangiectasia  tnf  transfected  understood 
Tagcloud (Intersection) ?