MDM2 and DLG4

Number of citations of the paper that reports this interaction (PubMedID 23260144)
47

Data Source:
BioGRID (pull down)

		MDM2	DLG4
Description		MDM2 proto-oncogene	discs large MAGUK scaffold protein 4
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Nuclear Body Transcription Repressor Complex Endocytic Vesicle Membrane Protein-containing Complex Centriolar Satellite Glutamatergic Synapse	Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Adherens Junction Synaptic Vesicle Voltage-gated Potassium Channel Complex Postsynaptic Density Membrane Cell Junction Axon Dendrite Endocytic Vesicle Membrane Cortical Cytoskeleton Neuromuscular Junction AMPA Glutamate Receptor Complex Dendrite Cytoplasm Cell Projection Neuron Projection Dendritic Spine Organelle Juxtaparanode Region Of Axon Cerebellar Mossy Fiber Neuron Projection Terminus Neuron Spine Synapse Postsynaptic Membrane Excitatory Synapse Cell Periphery Synaptic Membrane Presynapse Postsynapse Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	P53 Binding Ubiquitin-protein Transferase Activity Protein Binding 5S RRNA Binding Zinc Ion Binding Transferase Activity Ligase Activity SUMO Transferase Activity Enzyme Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Receptor Serine/threonine Kinase Binding Identical Protein Binding Peroxisome Proliferator Activated Receptor Binding Ribonucleoprotein Complex Binding Ubiquitin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity NEDD8 Ligase Activity Disordered Domain Specific Binding	Protein Binding Kinase Binding Protein Kinase Binding Protein Phosphatase Binding PDZ Domain Binding Protein-macromolecule Adaptor Activity Beta-1 Adrenergic Receptor Binding D1 Dopamine Receptor Binding P2Y1 Nucleotide Receptor Binding Acetylcholine Receptor Binding Ionotropic Glutamate Receptor Binding Protein-containing Complex Binding Neuroligin Family Protein Binding Scaffold Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Blood Vessel Development Blood Vessel Remodeling Regulation Of Heart Rate Heart Valve Development Atrioventricular Valve Morphogenesis Endocardial Cushion Morphogenesis Ventricular Septum Development Atrial Septum Development Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Traversing Start Control Point Of Mitotic Cell Cycle Heart Development Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Response To Toxic Substance Response To Iron Ion Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Protein Processing Negative Regulation Of Neuron Projection Development Protein Ubiquitination Protein Sumoylation DNA Damage Response, Signal Transduction By P53 Class Mediator Protein Destabilization Response To Magnesium Ion Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Localization To Nucleus Regulation Of Protein Catabolic Process Response To Cocaine Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Protein-containing Complex Organization Establishment Of Protein Localization Response To Ether Positive Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Positive Regulation Of Mitotic Cell Cycle Response To Antibiotic Positive Regulation Of Protein Export From Nucleus Response To Steroid Hormone Positive Regulation Of Muscle Cell Differentiation Proteolysis Involved In Protein Catabolic Process Regulation Of Cell Cycle Protein Autoubiquitination Cardiac Septum Morphogenesis Protein-containing Complex Assembly Regulation Of Biological Quality Cellular Response To Hydrogen Peroxide Cellular Response To Antibiotic Cellular Response To Vitamin B1 Cellular Response To Alkaloid Cellular Response To Growth Factor Stimulus Cellular Response To Peptide Hormone Stimulus Cellular Response To Estrogen Stimulus Cellular Response To Hypoxia Cellular Response To Gamma Radiation Cellular Response To UV-C Signal Transduction By P53 Class Mediator Fibroblast Activation Cellular Response To Actinomycin D Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Response To Formaldehyde Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Amyloid Fibril Formation Response To Water-immersion Restraint Stress Negative Regulation Of Apoptotic Signaling Pathway	Negative Regulation Of Receptor Internalization Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Chemical Synaptic Transmission Nervous System Development Learning Synaptic Vesicle Maturation Social Behavior Protein Localization To Synapse Locomotory Exploration Behavior Cellular Response To Potassium Ion Establishment Of Protein Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Synaptic Transmission Neuromuscular Process Controlling Balance Dendritic Spine Morphogenesis Protein-containing Complex Assembly Vocalization Behavior AMPA Glutamate Receptor Clustering Receptor Localization To Synapse Cell-cell Adhesion NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Neuron Projection Arborization Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Grooming Behavior
Pathways		AKT phosphorylates targets in the cytosol Oxidative Stress Induced Senescence Oncogene Induced Senescence SUMOylation of transcription factors SUMOylation of ubiquitinylation proteins Trafficking of AMPA receptors Constitutive Signaling by AKT1 E17K in Cancer Ub-specific processing proteases Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Methylation Stabilization of p53 Regulation of RUNX3 expression and activity Signaling by ALK fusions and activated point mutants Degradation of CDH1 NPAS4 regulates expression of target genes	Signaling by ERBB4 Trafficking of AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor NrCAM interactions Activation of Ca-permeable Kainate Receptor RHO GTPases activate CIT RAF/MAP kinase cascade LGI-ADAM interactions Neurexins and neuroligins Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs		Zinc Cis-[4,5-Bis-(4-Bromophenyl)-2-(2-Ethoxy-4-Methoxyphenyl)-4,5-Dihydroimidazol-1-Yl]-[4-(2-Hydroxyethyl)Piperazin-1-Yl]Methanone Cis-[4,5-Bis-(4-Chlorophenyl)-2-(2-Isopropoxy-4-Methoxyphenyl)-4,5-Dihyd Roimidazol-1-Yl]-Piperazin-1-Yl-Methanone Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Guanidine Guanosine-5'-Monophosphate
Diseases		Penile cancer Alveolar rhabdomyosarcoma Choriocarcinoma Osteosarcoma Glioma
GWAS		Pneumoconiosis in silica exposure ( 24986923) Red blood cell count ( 32888494)	Cholesterol, total ( 24097068 25961943) Hematocrit ( 32888494) Hemoglobin ( 32888494) LDL cholesterol ( 24097068 25961943) LDL cholesterol levels ( 28334899) Liver enzyme levels (alkaline phosphatase) ( 22001757 33972514) Serum alkaline phosphatase levels ( 29403010 33547301)
Interacting Genes		271 interacting genes: ABL1 ABL2 ADRB2 AKAP5 AKT1 ANKRD17 APEX1 APOB APP AR ARRB1 ARRB2 ATF3 ATF4 ATM ATP2A2 ATRX AURKA BAIAP2L1 BRINP1 BTK BTRC CANX CASP2 CASP3 CCAR1 CCDC3 CCNG1 CDC34 CDKN2A CHEK2 CLSTN1 CLU COPS5 CREBBP CSNK2A1 CSNK2A2 CSNK2B CTBP2 CWC25 DAPK1 DAPK3 DAXX DDX24 DDX42 DHFR DLG4 DNAJB4 DYRK2 EGLN3 EID1 EP300 ESR1 EZR F3 FBXO31 FHL2 FKBP1A FOS FOXO1 FOXO3 FOXP3 G3BP2 GADD45A GCAT GLIS2 GNL3 GORAB GRK2 GSK3B GTF2E2 GYS2 H2BC21 H3-4 HCK HDAC1 HEY1 HIF1A HIPK2 HLA-DMB HMGA2 HMGN1 HNRNPK HSP90B1 IER3 IGF1R IL33 IRF1 IRF2 JMY JUN JUND KAT2B KAT5 KIAA1671 KPNA1 LMO7 MAGEA2 MAGEC2 MAP1LC3A MAP2 MAPKAPK2 MAPT MDM4 MED1 MKRN3 MS4A1 MTBP MYC MYD88 MYDGF NACA NAT10 NCL NDUFS1 NGFR NOLC1 NOTCH1 NPIPB3 NPM1 NR1I2 NR3C1 NRON NUCKS1 NUMB OVOL2 PADI4 PAK6 PBX1 PBXIP1 PDCD1 PDE4D PDIA3 PDLIM7 PDS5A PGAM2 PHF7 PHLDB3 PIAS1 PJA1 PKM PLK1 PML POLE POT1 PPIB PPM1D PPP1R10 PRDM2 PRKN PSMA3 PSMC5 PSMD10 PSMD4 PSME3 PTK2 RAB8A RAD23A RALY RANBP1 RANBP2 RARA RASSF1 RB1 RBBP6 RBM10 RBM38 RESF1 RIDA RLIM RNF10 RNF115 RNF126 RNF8 RPL11 RPL22 RPL26 RPL36A RPL4 RPL5 RPS23 RPS3 RPS5 RRM2B RRP1 RSL1D1 RUVBL2 RYBP RYR2 S100A1 S100A2 S100A4 S100A6 S100B SDHC SESN2 SET SETD7 SETDB1 SHPK SIRT2 SIRT3 SMARCA2 SMARCA4 SMARCE1 SMG7 SNCA SORBS2 SRC SREK1 SRSF11 SUMO1 TAF1 TBP TCAP TFIP11 TOP1 TP53 TP53I3 TP53RK TP73 TPR TPT1 TRAF5 TRIB3 TRIM13 TRIM23 TRIM27 TRIM4 TRIM9 TSG101 UBB UBC UBE2A UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G2 UBE2H UBE2I UBE2J2 UBE2K UBE2L3 UBE2N UBE2O UBE2Q1 UBE2Q2 UBE2R2 UBE2S UBE2U UBE2Z UBE3A UBQLN4 UBTF USP15 USP2 USP7 VCP VEGFA WRN WT1 XBP1 XIAP XPC YY1AP1 ZNF133 ZNF420	139 interacting genes: ABHD17A ACTN2 ADGRB1 ADGRB2 ADGRL1 ADRB1 AKAP5 ARHGAP32 ARRB2 ASIC3 ATP2B2 ATP2B4 BEGAIN CACNG2 CASK CD46 CIT CLU CNKSR2 CRHR1 CRIPT CYLD DLG2 DLG3 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DRD1 DSCAM DYNLL1 EEF1G EFNB2 ERBB2 ERBB4 ERBIN EXOC4 FTH1 FYN FZD1 FZD2 FZD4 FZD7 GDA GLS2 GNG13 GOLGA2 GPSM2 GRIK1 GRIK2 GRIK5 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D GRIN3A GRIN3B GUCY1A2 HGS HNRNPC HTR2A HTR2C HTT IL13RA1 KCNA1 KCNA2 KCNA3 KCNA4 KCNA5 KCND2 KCNJ10 KCNJ12 KCNJ2 KCNJ4 KHDRBS1 KIF13B KIF1B LIN7A LIN7B LRFN1 LRP1 LRP2 LRP8 LRRC1 LYN LZTS2 MAP1A MAP3K10 MAPK12 MDM2 MPND MPP1 MT-CO1 NCKIPSD NDOR1 NLGN1 NLGN2 NLGN3 NLGN4X NOMO1 NOS1 PCDH10 PCMT1 PEX19 PICK1 PRKCA PRR16 PTK2B PTPRG RALBP1 RASSF4 RPS6KA1 SCN5A SEMA4B SEMA4C SEMA4F SEMA4G SHANK1 SHANK2 SIPA1L1 SLC4A7 SPRR2A SRC SYNGAP1 TAMALIN TANC1 THOC3 TIAM1 TJAP1 TRAF6 TUBB2B UBE3A VANGL2 VMAC WDR74 WNT3A YES1 ZDHHC17
Entrez ID		4193	1742
HPRD ID		01272	04199
Ensembl ID		ENSG00000135679	ENSG00000132535
Uniprot IDs		A0A0A8KB75 A7UKX7 A7UKX8 A7UKX9 G3XA89 Q00987 Q96DS0	A0A3B3IS17 B7Z4H2 B7Z647 B9EGL1 P78352
PDB IDs		1RV1 1T4E 1T4F 1YCR 1Z1M 2AXI 2C6A 2C6B 2F1Y 2FOP 2GV2 2HDP 2LZG 2M86 2MPS 2RUH 2VJE 2VJF 3EQS 3G03 3IUX 3IWY 3JZK 3JZR 3JZS 3LBK 3LBL 3LNJ 3LNZ 3MQS 3TJ2 3TPX 3TU1 3V3B 3VBG 3VZV 3W69 4DIJ 4ERE 4ERF 4HBM 4HFZ 4HG7 4JV7 4JV9 4JVE 4JVR 4JWR 4MDN 4MDQ 4OAS 4OBA 4OCC 4ODE 4ODF 4OGN 4OGT 4OGV 4OQ3 4QO4 4QOC 4UD7 4UE1 4UMN 4WT2 4XXB 4ZFI 4ZGK 4ZYC 4ZYF 4ZYI 5AFG 5C5A 5HMH 5HMI 5HMK 5J7F 5J7G 5LAV 5LAW 5LAY 5LAZ 5LN2 5MNJ 5OAI 5OC8 5SWK 5TRF 5UMM 5VK0 5WTS 5XXK 5Z02 5ZXF 6AAW 6GGN 6H22 6HFA 6I29 6I3S 6IM9 6KZU 6Q96 6Q9H 6Q9L 6Q9O 6SQO 6T2D 6T2E 6T2F 6Y4Q 6YR6 7AD0 7AI0 7AI1 7AYE 7BIR 7BIT 7BIV 7BJ0 7BJ6 7BMG 7KJM 7NA1 7NA2 7NA3 7NA4 7NUS 7QDQ 8AEU 8BGU 8EI9 8EIA 8EIB 8EIC 8F0Z 8F10 8F12 8F13 8GCG 8J81 8P0D 8PWC 9GFC	1KEF 2MES 3I4W 3K82 3ZRT 5J7J 5JXB 6QJD 6QJF 6QJG 6QJI 6QJJ 6QJK 6QJL 6QJN 6SPV 6SPZ 8AH4 8AH5 8AH6 8AH7 8AH8
Enriched GO Terms of Interacting Partners?		Nucleus Nucleoplasm Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Ubiquitin Conjugating Enzyme Activity Positive Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Protein Modification Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Protein Metabolic Process Regulation Of Programmed Cell Death Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Apoptotic Process Post-translational Protein Modification Protein Modification By Small Protein Conjugation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Protein Metabolic Process Modification-dependent Protein Catabolic Process Regulation Of RNA Metabolic Process Protein Ubiquitination Regulation Of Signal Transduction Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Proteolysis Involved In Protein Catabolic Process Positive Regulation Of RNA Biosynthetic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Macromolecule Biosynthetic Process Macromolecule Catabolic Process DNA Damage Response Positive Regulation Of Biosynthetic Process Regulation Of Gene Expression Regulation Of Signal Transduction By P53 Class Mediator Cytosol Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of Signaling Regulation Of Cell Communication Response To Stress	Synapse Glutamatergic Synapse Postsynaptic Density Membrane Plasma Membrane Postsynaptic Membrane Modulation Of Chemical Synaptic Transmission Postsynaptic Density Regulation Of Membrane Potential Regulation Of Biological Quality Ionotropic Glutamate Receptor Signaling Pathway Membrane Regulation Of Signaling Regulation Of Cell Communication Scaffold Protein Binding Synaptic Signaling Chemical Synaptic Transmission Dendrite Regulation Of Synapse Organization Trans-synaptic Signaling Glutamate Receptor Signaling Pathway Regulation Of Postsynaptic Membrane Potential Signaling Ligand-gated Ion Channel Signaling Pathway Metal Ion Transport Cell Communication Presynaptic Membrane NMDA Selective Glutamate Receptor Complex PDZ Domain Binding Monoatomic Cation Transport Monoatomic Ion Transport Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Synaptic Transmission, Glutamatergic Regulation Of System Process Cell-cell Signaling NMDA Glutamate Receptor Activity Modulation Of Excitatory Postsynaptic Potential Regulation Of Synaptic Plasticity Dendritic Spine Signal Transduction Monoatomic Ion Channel Activity Protein Localization To Synapse Synaptic Transmission, Glutamatergic Positive Regulation Of Excitatory Postsynaptic Potential Ligand-gated Monoatomic Ion Channel Activity Monoatomic Ion Channel Complex Regulation Of Transport Cell Surface Receptor Signaling Pathway Regulation Of Monoatomic Ion Transmembrane Transport Monoatomic Ion Transmembrane Transport Regulation Of Synapse Assembly
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?