MDM2 and DYRK2

Number of citations of the paper that reports this interaction (PMID 19965871)
11

Data Source:
BioGRID (affinity chromatography technology, enzymatic study, affinity chromatography technology)

		MDM2	DYRK2
Gene Name		MDM2 proto-oncogene, E3 ubiquitin protein ligase	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Nuclear Body Endocytic Vesicle Membrane Protein Complex Synapse	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Ribonucleoprotein Complex
	Molecular Function	P53 Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Enzyme Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Peroxisome Proliferator Activated Receptor Binding Ubiquitin Protein Ligase Activity Scaffold Protein Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Manganese Ion Binding Ubiquitin Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Protein Complex Assembly DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Traversing Start Control Point Of Mitotic Cell Cycle Epidermal Growth Factor Receptor Signaling Pathway Synaptic Transmission Positive Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Response To Carbohydrate Response To Iron Ion Positive Regulation Of Gene Expression Viral Process Protein Ubiquitination Peptidyl-lysine Modification Protein Destabilization Response To Magnesium Ion Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Localization To Nucleus Fc-epsilon Receptor Signaling Pathway Regulation Of Protein Catabolic Process Response To Cocaine Response To Drug Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Morphine Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Innate Immune Response Establishment Of Protein Localization Response To Ether Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Mitotic Cell Cycle Response To Antibiotic Positive Regulation Of Protein Export From Nucleus Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Cellular Response To Hydrogen Peroxide Negative Regulation Of Cell Cycle Arrest Cellular Response To Acid Chemical Cellular Response To Antibiotic Cellular Response To Vitamin B1 Cellular Response To Alkaloid Cellular Response To Peptide Hormone Stimulus Cellular Response To Estrogen Stimulus Cellular Response To Hypoxia Cellular Response To UV-C	Protein Phosphorylation Cellular Response To DNA Damage Stimulus Smoothened Signaling Pathway Peptidyl-tyrosine Phosphorylation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Glycogen Biosynthetic Process Negative Regulation Of NFAT Protein Import Into Nucleus
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease Cellular Senescence p53-Dependent G1/S DNA damage checkpoint AKT phosphorylates targets in the cytosol Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade Stabilization of p53 Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Signaling by PDGF DAP12 interactions GAB1 signalosome Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling PI3K/AKT Signaling in Cancer Adaptive Immune System Transmission across Chemical Synapses PIP3 activates AKT signaling Oncogene Induced Senescence p53-Dependent G1 DNA Damage Response PI3K events in ERBB2 signaling Downstream signaling of activated FGFR G1/S DNA Damage Checkpoints Innate Immune System Signalling by NGF Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Trafficking of AMPA receptors Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR Oxidative Stress Induced Senescence Cell Cycle Checkpoints Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity
Drugs		Cis-[4,5-Bis-(4-Bromophenyl)-2-(2-Ethoxy-4-Methoxyphenyl)-4,5-Dihydroimidazol-1-Yl]-[4-(2-Hydroxyethyl)Piperazin-1-Yl]Methanone Cis-[4,5-Bis-(4-Chlorophenyl)-2-(2-Isopropoxy-4-Methoxyphenyl)-4,5-Dihyd Roimidazol-1-Yl]-Piperazin-1-Yl-Methanone
Diseases
GWAS
Protein-Protein Interactions		185 interactors: ABL1 ADRB2 ADRBK1 AKT1 ANKRD17 APEX1 APP AR ARRB2 ATF3 ATF4 ATM ATP2A2 AURKA BAIAP2L1 BRINP1 BTRC CANX CASP2 CASP3 CCAR1 CCNG1 CDH1 CDKN2A CHEK2 CLSTN1 CLU COPS5 CREBBP CTBP2 CWC25 DAPK1 DAPK3 DAXX DHFR DLG4 DNAJB4 DYRK2 E2F1 EID1 EP300 ESR1 EZR FOXO1 G3BP2 GADD45A GCAT GLTSCR2 GNL3 GORAB GSK3B GTF2E1 GTF2E2 HDAC1 HIF1A HIPK2 HIST2H2BE HIST3H3 HLA-DMB HRSP12 HSP90B1 IGF1R IRF1 IRF2 JMY JUN JUND KAT2B KAT5 LMO7 MDM4 MED1 MKRN3 MS4A1 MTBP MYD88 MYDGF NACA NCL NOTCH1 NPM1 NR3C1 NUMB PAK6 PBX1 PDE4D PDIA3 PDLIM7 PGAM2 PHF7 PIAS1 PJA1 PKM PLK1 PML POLE POT1 PPIB PPM1D PSMA3 PSMC5 PSMD10 PSMD4 PSME3 PTK2 RAB8A RABL6 RAD23A RANBP1 RANBP2 RASSF1 RB1 RBM38 RCHY1 RNF10 RNF126 RNF8 RPL11 RPL26 RPL5 RPS23 RPS27A RPS3 RPS7 RRM2B RUVBL2 RYBP RYR2 S100A1 S100A2 S100A4 S100A6 S100B SDHC SENP3 SESN2 SET SETDB1 SHPK SMARCA2 SMARCA4 SMARCE1 SORBS2 SREK1 SRSF11 SUMO1 TAF1 TBP TCAP TERT TOP1 TP53 TP73 TPR TPT1 TRAF5 TRIM23 TRIM27 TRIM4 TRIM9 TSC22D3 TSG101 UBB UBE2A UBE2D1 UBE2D2 UBE2D3 UBE2E2 UBE2E3 UBE2G2 UBE2I UBE2K UBE2L3 UBE2M UBE2U UBE2Z UBE3A UBQLN4 UBTF USP2 USP7 WT1 XPC YY1AP1 ZNF133	20 interactors: APP ATM DDB1 DYRK4 HIST2H2BE HIST3H3 IKZF1 KATNA1 KXD1 LZTS2 MDM2 NR1I2 RAD54B SIAH2 SP100 TERT UBC UBR5 WDR62 ZBTB9
Entrez ID		4193	8445
HPRD ID		01272	04606
Ensembl ID		ENSG00000135679
Uniprot IDs		A7UKX7 A7UKX8 A7UKX9 G3XA89 Q00987 Q96DS0	Q92630
PDB IDs		1RV1 1T4E 1T4F 1YCR 1Z1M 2AXI 2C6A 2C6B 2F1Y 2FOP 2GV2 2HDP 2LZG 2M86 2VJE 2VJF 3EQS 3G03 3IUX 3IWY 3JZK 3JZR 3JZS 3LBK 3LBL 3LNJ 3LNZ 3TJ2 3TPX 3TU1 3V3B 3VBG 3VZV 3W69 4DIJ 4ERE 4ERF 4HBM 4HFZ 4JV7 4JV9 4JVE 4JVR 4JWR	3K2L 3KVW 4AZF
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Cycle Negative Regulation Of Cellular Metabolic Process Cellular Response To Stress Viral Process Cell Cycle Process Cell Cycle Regulation Of Mitotic Cell Cycle Positive Regulation Of Cellular Metabolic Process Cell Death Death Programmed Cell Death Protein Modification By Small Protein Conjugation Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Positive Regulation Of Metabolic Process Response To Stress Regulation Of Protein Metabolic Process Apoptotic Process Regulation Of Apoptotic Process Cellular Response To DNA Damage Stimulus Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Cell Death Regulation Of Cell Cycle Phase Transition Protein Ubiquitination Regulation Of Metabolic Process Negative Regulation Of Gene Expression Regulation Of Protein Catabolic Process Cellular Macromolecule Catabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of RNA Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Transcription, DNA-templated Protein Polyubiquitination Positive Regulation Of Cell Cycle Cellular Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Mitotic Cell Cycle Positive Regulation Of Cell Cycle Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process	Telomere Maintenance Intracellular Receptor Signaling Pathway DNA Damage Response, Signal Transduction By P53 Class Mediator Chromosome Organization Regulation Of Mitotic Cell Cycle Phase Transition Signal Transduction In Response To DNA Damage DNA Metabolic Process Regulation Of Cell Cycle Phase Transition Negative Regulation Of Cellular Metabolic Process Signal Transduction By P53 Class Mediator Cellular Response To DNA Damage Stimulus Regulation Of Wnt Signaling Pathway Cell Cycle Protein Catabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of Mitotic Cell Cycle Chromatin Organization Mitotic G1 DNA Damage Checkpoint Replicative Senescence Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Arrest Microtubule Severing Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Cycle Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Arrest Mitotic DNA Damage Checkpoint Proteolysis Involved In Cellular Protein Catabolic Process Organelle Organization Positive Regulation Of Cell Cycle Cellular Protein Catabolic Process Protein Ubiquitination Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Repair Chromatin Modification Protein Modification By Small Protein Conjugation
Tagcloud ?		abundance bound cbp coactivator destabilizer directed e1a endogenous h1 implies implying interactions intimately naturally normally occurring operate overproducing p300 p53 regard serves stability stabilizing steps taken translates turnover underscored	better clinicopathological closely december dual free grade histological hormone hundred ihc immunohistochemical involvement january lymph metastasis node predict predictive prognosis recurrence seventy specificity stage status surgery ten underwent
Tagcloud (Difference) ?		abundance bound cbp coactivator destabilizer directed e1a endogenous h1 implies implying interactions intimately naturally normally occurring operate overproducing p300 p53 regard serves stability stabilizing steps taken translates turnover underscored	better clinicopathological closely december dual free grade histological hormone hundred ihc immunohistochemical involvement january lymph metastasis node predict predictive prognosis recurrence seventy specificity stage status surgery ten underwent
Tagcloud (Intersection) ?