LUC7L2 and APPBP2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		LUC7L2	APPBP2
Description		LUC7 like 2, pre-mRNA splicing factor	amyloid beta precursor protein binding protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm U1 SnRNP Nuclear Speck U2-type Prespliceosome	Nucleus Nucleoplasm Cytoplasm Cytoskeleton Microtubule Microtubule Associated Complex Membrane Cytoplasmic Vesicle Membrane Cul2-RING Ubiquitin Ligase Complex
	Molecular Function	RNA Binding MRNA Binding Protein Binding Enzyme Binding	Microtubule Motor Activity Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	MRNA Splice Site Recognition	Intracellular Protein Transport Protein Transport Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intracellular Transport
Pathways
Drugs
Diseases
GWAS		Diisocyanate-induced asthma ( 25918132) Left ventricular end-diastolic volume (MTAG) ( 33495596) Left ventricular end-systolic volume (MTAG) ( 33495596)	Interleukin-6 levels ( 33517400) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Waist-hip ratio ( 28552196)
Interacting Genes		67 interacting genes: AIMP2 ALB ANKHD1 ANTKMT AP2M1 APP APPBP2 ATF7IP ATRX C1orf35 CADPS CDC37 CDK4 CDK5RAP2 CEP126 CHD3 COXFA4L2 DHX8 DZIP1 EXOC1 FXR1 GADD45G GSK3B HAP1 HDHD2 HOXA1 IKBKG ITPRID2 KLHL20 LPL MAN2A2 MAP1LC3B MEOX2 NAP1L5 NASP NAT9 NDEL1 NEDD4 NFYA NKAP NSF NUTF2 OFD1 OGT PDPK1 PEA15 PIK3R3 PRPF38A PTCD3 PTN RHOA SAT1 SETDB1 SNRNP48 SRPK2 SRRM4 SRSF6 SRSF7 SRSF8 SVIL ULK2 UNC119 WASHC3 WEE2-AS1 YWHAG ZCCHC10 ZRSR2	122 interacting genes: - AADAC ACTN1 AHCY AIM2 AK3 ALDH1L1 ANKRD10 APP AR ARMCX5 ASCC3 ATP13A1 BCL7A BIN2 C1orf50 CALM3 CCDC167 CCDC85C CCNL1 CDK16 CHMP5 CIBAR1 CLCN1 CNTFR COL24A1 CORO2B CREB3 CSNK1G2 CST2 CTC1 CYBA DCD DHRS2 DHX16 DOLK DPEP1 DPYS EID3 ERO1A FAM107A FSTL1 FXYD7 GALNT3 GCSAM GP9 GPRC5C GSTP1 H2AC15 HGFAC HIPK4 HSD3B7 HSPA4 ITGB4 ITGB5 KHK KIF6 KLF11 KLHL35 LANCL2 LONRF3 LUC7L2 LUZP4 MAN2B2 MCOLN1 MGAT4B MLLT3 MMP28 MRPL28 MSH2 MSLN MUL1 MYLK NFYA NHERF1 NPRL3 PCSK5 PEX39 PI4KAP2 PNPLA5 PPIL6 PPP1R8 PRKAA2 PRKACB PSAP PTCH1 PYROXD2 RAB7B RASSF5 RHEB RILPL1 RNF128 RNF34 RNGTT RRS1 SELENOI SELENOV SLC22A6 SLC25A23 SLC33A2 SLC7A10 SNX5 SPDYE2 SPDYE2B ST8SIA5 SYNRG SYT11 TAF11 TAFA4 TBL3 TCF25 TNP2 TRMT2A UBE2R2 UGGT2 WAS WDR24 WFIKKN1 WNT5B ZC3H10 ZCCHC12 ZNF747
Entrez ID		51631	10513
HPRD ID		17456	05616
Ensembl ID		ENSG00000146963	ENSG00000062725
Uniprot IDs		Q9Y383	Q92624
PDB IDs			8JAL 8JAQ 8JAR 8JAS 8JAU 8JAV
Enriched GO Terms of Interacting Partners?		Protein Binding Negative Regulation Of Long-term Synaptic Potentiation Cytosol RNA Splicing Protein-containing Complex Organization Regulation Of Long-term Synaptic Potentiation Presynapse MRNA Processing Nucleus Cellular Component Assembly Low-density Lipoprotein Particle Mediated Signaling Regulation Of MRNA Splicing, Via Spliceosome Establishment Of Protein Localization Positive Regulation Of Neuron Apoptotic Process Microtubule Cytoskeleton Organization Involved In Mitosis Intracellular Protein Localization Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing RNA Binding Positive Regulation Of Protein Localization To Cilium Insulin Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Protein-containing Complex Assembly Microtubule Organizing Center Organization Positive Regulation Of Cilium Assembly Regulation Of MRNA Metabolic Process Nucleic Acid Binding Microtubule Associated Complex Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Spindle Organization Organelle Assembly MRNA Binding MRNA Metabolic Process Positive Regulation Of Organelle Assembly Regulation Of Protein Localization To Cilium Membraneless Organelle Assembly Regulation Of RNA Splicing Establishment Of Vesicle Localization	Protein Binding
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