LUC7L2 and NFYA

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		LUC7L2	NFYA
Description		LUC7 like 2, pre-mRNA splicing factor	nuclear transcription factor Y subunit alpha
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm U1 SnRNP Nuclear Speck U2-type Prespliceosome	Chromatin Nucleus Nucleoplasm CCAAT-binding Factor Complex Protein-DNA Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Binding MRNA Binding Protein Binding Enzyme Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	MRNA Splice Site Recognition	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process
Pathways			PPARA activates gene expression Activation of gene expression by SREBF (SREBP) Activation of gene expression by SREBF (SREBP) ATF4 activates genes in response to endoplasmic reticulum stress ATF6 (ATF6-alpha) activates chaperone genes ATF6 (ATF6-alpha) activates chaperone genes FOXO-mediated transcription of cell death genes
Drugs
Diseases
GWAS		Diisocyanate-induced asthma ( 25918132) Left ventricular end-diastolic volume (MTAG) ( 33495596) Left ventricular end-systolic volume (MTAG) ( 33495596)	Mean spheric corpuscular volume ( 32888494) White blood cell count ( 27863252)
Interacting Genes		67 interacting genes: AIMP2 ALB ANKHD1 ANTKMT AP2M1 APP APPBP2 ATF7IP ATRX C1orf35 CADPS CDC37 CDK4 CDK5RAP2 CEP126 CHD3 COXFA4L2 DHX8 DZIP1 EXOC1 FXR1 GADD45G GSK3B HAP1 HDHD2 HOXA1 IKBKG ITPRID2 KLHL20 LPL MAN2A2 MAP1LC3B MEOX2 NAP1L5 NASP NAT9 NDEL1 NEDD4 NFYA NKAP NSF NUTF2 OFD1 OGT PDPK1 PEA15 PIK3R3 PRPF38A PTCD3 PTN RHOA SAT1 SETDB1 SNRNP48 SRPK2 SRRM4 SRSF6 SRSF7 SRSF8 SVIL ULK2 UNC119 WASHC3 WEE2-AS1 YWHAG ZCCHC10 ZRSR2	50 interacting genes: APP APPBP2 ATF6 ATF6B ATXN1 BANP BRCA1 CCNA2 CDC25A CDK2 CDKN1A CEBPA CSNK2A1 DVL3 E2F6 ELF1 EP300 GTF2A1 HMGA1 JUN KPNB1 LUC7L2 NFYB NFYC NR5A1 PAPOLG POGZ POU2F1 POU3F2 PWP1 QRICH1 SP1 SPI1 SREBF2 SRF SRSF1 TAF11 TAF12 TAF6 TCAF1 TOPBP1 TP53 UBL5 USF1 USF2 VEZF1 ZC3H10 ZHX1 ZHX2 ZHX3
Entrez ID		51631	4800
HPRD ID		17456	01793
Ensembl ID		ENSG00000146963	ENSG00000001167
Uniprot IDs		Q9Y383	P23511
PDB IDs			4AWL 6QMP 6QMQ 6QMS 8QU2 8QU3 8QU4
Enriched GO Terms of Interacting Partners?		Protein Binding Negative Regulation Of Long-term Synaptic Potentiation Cytosol RNA Splicing Protein-containing Complex Organization Regulation Of Long-term Synaptic Potentiation Presynapse MRNA Processing Nucleus Cellular Component Assembly Low-density Lipoprotein Particle Mediated Signaling Regulation Of MRNA Splicing, Via Spliceosome Establishment Of Protein Localization Positive Regulation Of Neuron Apoptotic Process Microtubule Cytoskeleton Organization Involved In Mitosis Intracellular Protein Localization Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing RNA Binding Positive Regulation Of Protein Localization To Cilium Insulin Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Protein-containing Complex Assembly Microtubule Organizing Center Organization Positive Regulation Of Cilium Assembly Regulation Of MRNA Metabolic Process Nucleic Acid Binding Microtubule Associated Complex Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Spindle Organization Organelle Assembly MRNA Binding MRNA Metabolic Process Positive Regulation Of Organelle Assembly Regulation Of Protein Localization To Cilium Membraneless Organelle Assembly Regulation Of RNA Splicing Establishment Of Vesicle Localization	Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Nucleoplasm Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process DNA Binding Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Nucleus Regulation Of Primary Metabolic Process Chromatin Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Regulation Of Macromolecule Metabolic Process Protein Heterodimerization Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Metabolic Process Transcription Regulator Complex RNA Polymerase II Transcription Regulator Complex RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of DNA-templated Transcription Initiation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Initiation Transcription Cis-regulatory Region Binding DNA-templated Transcription Sequence-specific DNA Binding Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Positive Regulation Of MiRNA Transcription Negative Regulation Of Macromolecule Biosynthetic Process Nucleic Acid Metabolic Process Cellular Senescence Positive Regulation Of MiRNA Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Transcription Initiation By RNA Polymerase II RNA Metabolic Process ER-nucleus Signaling Pathway
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