LUC7L2 and PDPK1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		LUC7L2	PDPK1
Description		LUC7 like 2, pre-mRNA splicing factor	3-phosphoinositide dependent protein kinase 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm U1 SnRNP Nuclear Speck U2-type Prespliceosome	Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Postsynaptic Density Membrane Cytoplasmic Vesicle Cell Projection Anchoring Junction
	Molecular Function	RNA Binding MRNA Binding Protein Binding Enzyme Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity 3-phosphoinositide-dependent Protein Kinase Activity Protein Binding ATP Binding Phospholipase Activator Activity Kinase Activity Transferase Activity Phospholipase Binding Protein Serine Kinase Activity
	Biological Process	MRNA Splice Site Recognition	Type B Pancreatic Cell Development Protein Phosphorylation Hyperosmotic Response Epidermal Growth Factor Receptor Signaling Pathway Insulin Receptor Signaling Pathway Regulation Of Endothelial Cell Migration Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Cell Migration Calcium-mediated Signaling Actin Cytoskeleton Organization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway T Cell Costimulation Cellular Response To Insulin Stimulus Negative Regulation Of Toll-like Receptor Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Mast Cell Degranulation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Protein Autophosphorylation Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Epidermal Growth Factor Stimulus Extrinsic Apoptotic Signaling Pathway Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Intracellular Signaling Cassette Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Vascular Endothelial Cell Proliferation Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways			GPVI-mediated activation cascade GPVI-mediated activation cascade PIP3 activates AKT signaling Activation of AKT2 Downstream TCR signaling Role of LAT2/NTAL/LAB on calcium mobilization FCERI mediated NF-kB activation Integrin signaling CD28 dependent PI3K/Akt signaling G beta:gamma signalling through PI3Kgamma RSK activation VEGFR2 mediated vascular permeability VEGFR2 mediated cell proliferation CLEC7A (Dectin-1) signaling RHO GTPases activate PKNs Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation Estrogen-stimulated signaling through PRKCZ Estrogen-stimulated signaling through PRKCZ SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs			Celecoxib Inositol 1,3,4,5-Tetrakisphosphate 7-Hydroxystaurosporine Bisindolylmaleimide VIII Staurosporine Bisindolylmaleimide I Dexfosfoserine 10,11-dimethoxy-4-methyldibenzo[c,f]-2,7-naphthyridine-3,6-diamine 5-HYDROXY-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-2-ONE 1-{2-OXO-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-5-YL}UREA 2-(1H-imidazol-1-yl)-9-methoxy-8-(2-methoxyethoxy)benzo[c][2,7]naphthyridin-4-amine 3-(1H-indol-3-yl)-4-(1-{2-[(2S)-1-methylpyrrolidinyl]ethyl}-1H-indol-3-yl)-1H-pyrrole-2,5-dione 3-[1-(3-AMINOPROPYL)-1H-INDOL-3-YL]-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE Fostamatinib
Diseases
GWAS		Diisocyanate-induced asthma ( 25918132) Left ventricular end-diastolic volume (MTAG) ( 33495596) Left ventricular end-systolic volume (MTAG) ( 33495596)	Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		67 interacting genes: AIMP2 ALB ANKHD1 ANTKMT AP2M1 APP APPBP2 ATF7IP ATRX C1orf35 CADPS CDC37 CDK4 CDK5RAP2 CEP126 CHD3 COXFA4L2 DHX8 DZIP1 EXOC1 FXR1 GADD45G GSK3B HAP1 HDHD2 HOXA1 IKBKG ITPRID2 KLHL20 LPL MAN2A2 MAP1LC3B MEOX2 NAP1L5 NASP NAT9 NDEL1 NEDD4 NFYA NKAP NSF NUTF2 OFD1 OGT PDPK1 PEA15 PIK3R3 PRPF38A PTCD3 PTN RHOA SAT1 SETDB1 SNRNP48 SRPK2 SRRM4 SRSF6 SRSF7 SRSF8 SVIL ULK2 UNC119 WASHC3 WEE2-AS1 YWHAG ZCCHC10 ZRSR2	68 interacting genes: AKT1 AKT2 AKT3 AKTIP APBB3 APP BLMH CARD11 CDAN1 CSK CSNK1D CUL3 DDIT4 GIT1 GSK3B HSP90AA1 ILK IRS1 ITGB3 KATNBL1 KLHL20 LUC7L2 MAPK8 MTOR NHERF2 PAK1 PEA15 PHAX PIK3C3 PKN1 PKN2 PNO1 POLDIP2 PRKACA PRKCB PRKCD PRKCE PRKCI PRKCZ PRSS23 PRXL2B PTK2B PXN RALGDS RPS6KA1 RPS6KA3 RPS6KB1 RPS6KB2 SBF1 SGK1 SGK2 SGK3 SMARCB1 SOCS3 SPOP SRC SRPK1 STRAP TCAP UBC UBE2I WDCP XPO7 XRCC6 YWHAH YWHAQ ZC3HC1 ZNF133
Entrez ID		51631	5170
HPRD ID		17456	05556
Ensembl ID		ENSG00000146963	ENSG00000140992
Uniprot IDs		Q9Y383	E9PER6 O15530
PDB IDs			1H1W 1OKY 1OKZ 1UU3 1UU7 1UU8 1UU9 1UVR 1W1D 1W1G 1W1H 1Z5M 2BIY 2PE0 2PE1 2PE2 2R7B 2VKI 2XCH 2XCK 3H9O 3HRC 3HRF 3ION 3IOP 3NAX 3NAY 3NUN 3NUS 3NUU 3NUY 3ORX 3ORZ 3OTU 3PWY 3QC4 3QCQ 3QCS 3QCX 3QCY 3QD0 3QD3 3QD4 3RCJ 3RWP 3RWQ 3SC1 4A06 4A07 4AW0 4AW1 4CT1 4CT2 4RQK 4RQV 4RRV 4XX9 5ACK 5HKM 5HNG 5HO7 5HO8 5LVL 5LVM 5LVN 5LVO 5LVP 5MRD 6WJQ 8DQT
Enriched GO Terms of Interacting Partners?		Protein Binding Negative Regulation Of Long-term Synaptic Potentiation Cytosol RNA Splicing Protein-containing Complex Organization Regulation Of Long-term Synaptic Potentiation Presynapse MRNA Processing Nucleus Cellular Component Assembly Low-density Lipoprotein Particle Mediated Signaling Regulation Of MRNA Splicing, Via Spliceosome Establishment Of Protein Localization Positive Regulation Of Neuron Apoptotic Process Microtubule Cytoskeleton Organization Involved In Mitosis Intracellular Protein Localization Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing RNA Binding Positive Regulation Of Protein Localization To Cilium Insulin Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Protein-containing Complex Assembly Microtubule Organizing Center Organization Positive Regulation Of Cilium Assembly Regulation Of MRNA Metabolic Process Nucleic Acid Binding Microtubule Associated Complex Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Spindle Organization Organelle Assembly MRNA Binding MRNA Metabolic Process Positive Regulation Of Organelle Assembly Regulation Of Protein Localization To Cilium Membraneless Organelle Assembly Regulation Of RNA Splicing Establishment Of Vesicle Localization	Protein Kinase Activity Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Kinase Activity Protein Phosphorylation Phosphorylation Intracellular Signal Transduction ATP Binding Protein Modification Process Cytosol Cellular Response To Peptide Hormone Stimulus Nucleotide Binding Cellular Response To Oxygen-containing Compound Protein Metabolic Process Cellular Response To Hormone Stimulus Cytoplasm Diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Cellular Response To Insulin Stimulus Nucleus TOR Signaling Transferase Activity TORC1 Signaling Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Insulin Receptor Signaling Pathway Response To Peptide Hormone Negative Regulation Of Cellular Response To Insulin Stimulus Response To Hormone Phosphate-containing Compound Metabolic Process Signal Transduction Regulation Of Signal Transduction Negative Regulation Of TOR Signaling Regulation Of Generation Of Precursor Metabolites And Energy Cellular Response To Insulin Stimulus Peptidyl-serine Phosphorylation Response To Fluid Shear Stress Regulation Of TOR Signaling Regulation Of Signaling Negative Regulation Of Apoptotic Process Regulation Of Cell Communication Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Programmed Cell Death Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Signal Transduction Cellular Response To Fluid Shear Stress Regulation Of Apoptotic Process Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Catabolic Process Positive Regulation Of Signal Transduction
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