LUC7L2 and NSF

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		LUC7L2	NSF
Gene Name		LUC7-like 2 (S. cerevisiae)	N-ethylmaleimide-sensitive factor
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	U1 SnRNP Nuclear Speck	Cytoplasm Lysosomal Membrane Golgi Stack Cytosol Plasma Membrane Postsynaptic Density Dendritic Shaft Extracellular Vesicular Exosome
	Molecular Function	MRNA Binding Protein Binding Enzyme Binding Poly(A) RNA Binding	Protein Binding ATP Binding ATPase Activity Syntaxin-1 Binding Rab GTPase Binding Protein Kinase Binding PDZ Domain Binding Protein Complex Binding ATPase Activity, Coupled Metal Ion Binding
	Biological Process	MRNA Splice Site Selection	Positive Regulation Of Receptor Recycling Potassium Ion Transport Exocytosis Intra-Golgi Vesicle-mediated Transport Synaptic Transmission Vesicle-mediated Transport Regulation Of Exocytosis Golgi To Plasma Membrane Protein Transport Plasma Membrane Fusion Golgi Vesicle Docking
Pathways			Trafficking of GluR2-containing AMPA receptors Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Trafficking of AMPA receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Transmission across Chemical Synapses
Drugs
Diseases
GWAS			Parkinson's disease ( 19915575 21812969)
Protein-Protein Interactions		54 interactors: AIMP2 ALB APP APPBP2 ATF7IP ATRX CADPS CCDC53 CDC37 CDK4 CDK5RAP2 CHD3 EXOC1 FAM173A FXR1 GADD45G GSK3B HAP1 HDHD2 IKBKG KIAA1377 KLHL20 LINC00341 LPL MAN2A2 MAP1LC3B NAP1L5 NASP NAT9 NDEL1 NDUFA4L2 NEDD4 NFYA NKAP NSF NUTF2 OFD1 PDPK1 PEA15 PIK3R3 PTCD3 PTN SAT1 SETDB1 SRPK1 SRPK2 SRSF6 SRSF7 SSFA2 SVIL ULK2 UNC119 YWHAG ZCCHC10	25 interactors: ARRB1 C14orf1 CD28 DRD2 EIF3E FUNDC2 GABARAP GABARAPL2 GABBR1 GABBR2 GOSR1 GRIA2 GRIA3 KIAA1377 LUC7L2 NAPA NAPG PTPN9 RAMP3 RPLP1 STX1A STX4 STX8 USO1 VAPA
Entrez ID		51631	4905
HPRD ID		17456	03380
Ensembl ID		ENSG00000146963	ENSG00000073969
Uniprot IDs		Q9Y383	P46459
PDB IDs
Enriched GO Terms of Interacting Partners?		Organelle Organization Establishment Of Localization In Cell Cellular Localization Protein Transport Regulation Of Kinase Activity Establishment Of Protein Localization Cell Cycle Process Anatomical Structure Development Intracellular Transport Cell Cycle Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Metabolic Process Developmental Process Regulation Of Protein Kinase Activity Cellular Component Assembly Positive Regulation Of Cell Cycle Regulation Of MRNA Processing Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Development Regulation Of Cell Differentiation Multicellular Organismal Development Regulation Of RNA Splicing Exocytosis Regulation Of Protein Metabolic Process Regulation Of Neurogenesis Establishment Of Cell Polarity Protein Localization Chromatin Organization Retrograde Axon Cargo Transport Regulation Of Cell Cycle Positive Regulation Of Cell Cycle Process Regulation Of Neuron Differentiation Nuclear Export Mitotic Cell Cycle Regulation Of Cell Size Apoptotic Process Axon Cargo Transport Programmed Cell Death Chromosome Organization Organelle Localization Regulation Of Cellular Process Regulation Of Cell Death Positive Regulation Of Mitotic Cell Cycle Phase Transition Cell Death Positive Regulation Of Metabolic Process Death Regulation Of Phosphorylation Positive Regulation Of Cell Cycle Phase Transition Regulation Of Protein Phosphorylation Regulation Of Gene Expression	Membrane Fusion Membrane Organization Intracellular Transport Golgi Vesicle Transport Protein Localization Establishment Of Localization In Cell Protein Transport Synaptic Transmission Vesicle-mediated Transport Establishment Of Protein Localization Cellular Localization Cell-cell Signaling Intracellular Protein Transport Vesicle Fusion Intra-Golgi Vesicle-mediated Transport Cellular Protein Localization Neuron-neuron Synaptic Transmission Organelle Fusion Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Vesicle Organization Negative Regulation Of CAMP Biosynthetic Process Transport Mitochondrion Degradation Negative Regulation Of CAMP Metabolic Process Negative Regulation Of Nucleotide Metabolic Process Organelle Disassembly Synaptic Transmission, Glutamatergic Receptor Internalization Regulation Of Synaptic Vesicle Priming Regulation Of Protein Localization To Plasma Membrane Regulation Of Adenylate Cyclase Activity Regulation Of Vesicle-mediated Transport Regulation Of Cyclase Activity Regulation Of Insulin Secretion Synaptic Vesicle Fusion To Presynaptic Membrane Cytoplasmic Transport Regulation Of Cellular Localization G-protein Coupled Receptor Internalization Regulation Of Peptide Hormone Secretion Cellular Component Assembly Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Receptor Metabolic Process Vesicle Docking Post-Golgi Vesicle-mediated Transport Regulation Of CAMP Biosynthetic Process Membrane Docking Regulation Of Protein Localization Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway
Tagcloud ?		add african alleles americans ankrd17 antihypertensive caucasian caucasians connections cox18 displaying diuretics elevations fto grin3a hctz heterozygotes hydrochlorothiazide hyperuricaemia padi4 pard3b pear pharmacogenomic replicated rs4784333 suggestive thiazide ua uric	acetate alkylating amount apical associate attachment bound caco cellubrevin coimmunoprecipitation colocalizes connection define docking epithelium ethylmaleimide munc myristate phorbol predominantly quantity sec1 snap snare snares syntaxin thought verified vesicles
Tagcloud (Difference) ?		add african alleles americans ankrd17 antihypertensive caucasian caucasians connections cox18 displaying diuretics elevations fto grin3a hctz heterozygotes hydrochlorothiazide hyperuricaemia padi4 pard3b pear pharmacogenomic replicated rs4784333 suggestive thiazide ua uric	acetate alkylating amount apical associate attachment bound caco cellubrevin coimmunoprecipitation colocalizes connection define docking epithelium ethylmaleimide munc myristate phorbol predominantly quantity sec1 snap snare snares syntaxin thought verified vesicles
Tagcloud (Intersection) ?