PIAS4 and IRF3

Number of citations of the paper that reports this interaction (PMID 15251447)
10

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		PIAS4	IRF3
Gene Name		protein inhibitor of activated STAT, 4	interferon regulatory factor 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Matrix PML Body	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding Ligase Activity SUMO Transferase Activity Ubiquitin Protein Ligase Binding SUMO Ligase Activity	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Cofactor Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity Transcription Regulatory Region DNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Wnt Signaling Pathway Protein Sumoylation Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Sumoylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Keratinocyte Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage	Negative Regulation Of Transcription From RNA Polymerase II Promoter Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription From RNA Polymerase II Promoter Apoptotic Process Cellular Response To DNA Damage Stimulus Viral Process Cytokine-mediated Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MDA-5 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Exogenous DsRNA Innate Immune Response Type I Interferon Biosynthetic Process Negative Regulation Of Interferon-beta Biosynthetic Process Negative Regulation Of Defense Response To Virus By Host Positive Regulation Of Cytokine Secretion Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Positive Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To DsRNA Macrophage Apoptotic Process Programmed Necrotic Cell Death
Pathways			Negative regulators of RIG-I/MDA5 signaling Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon Interferon gamma signaling Activated TLR4 signalling TRAF3-dependent IRF activation pathway ZBP1(DAI) mediated induction of type I IFNs IRF3 mediated activation of type 1 IFN STING mediated induction of host immune responses Interferon alpha/beta signaling Innate Immune System ISG15 antiviral mechanism TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA Interferon Signaling Cytokine Signaling in Immune system MyD88-independent cascade Factors involved in megakaryocyte development and platelet production Antiviral mechanism by IFN-stimulated genes Toll-Like Receptors Cascades RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Regulation of innate immune responses to cytosolic DNA Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production TRAF6 mediated IRF7 activation IRF3-mediated induction of type I IFN
Drugs
Diseases
GWAS
Protein-Protein Interactions		75 interactors: ACTN1 ALDOA AR BARD1 BRCA1 BTAF1 CALCOCO2 CEBPD CHD3 CLK1 COIL ESRRA FTH1 GADD45G HDAC1 HDAC2 HNF4A HNRNPUL1 HTT IL15RA IMMT IMPDH2 IRF3 IRF7 KPNB1 KRT18 LAMP2 LEF1 LRIF1 MAGEH1 MAP1LC3A MDC1 MPRIP NEFL NR4A2 OAZ1 OPTN PARP1 PDE4A PDE4D PDE4DIP PHF11 PHGDH PIAS1 PIAS2 PLAG1 PRPF40A PTN RIF1 SATB1 SERBP1 SERPINA5 SETDB1 SH3GL3 SKIL SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 SNIP1 SUMO1 SUMO2 SUMO3 TADA3 TCERG1 TICAM1 TP53 TRIM27 TRIM32 UBE2I UBE2K VIM ZHX1 ZNF512B	25 interactors: CREBBP EP300 EWSR1 GRIP1 HSP90AA1 IKBKE IRF5 IRF7 MAPK8 MAVS PEX19 PIAS4 PPIB PRDX1 RB1 RBL1 RELA SERPINB2 SGTA SMURF2 SYT1 TBK1 TICAM1 TICAM2 TOMM70A
Entrez ID		51588	3661
HPRD ID		06910	04769
Ensembl ID			ENSG00000126456
Uniprot IDs		Q8N2W9	E2GIM5 E2GIM6 E2GIM7 E2GIM8 E2GIM9 M0QYT9 Q14653
PDB IDs			1J2F 1QWT 1T2K 1ZOQ 2O61 2O6G 2PI0 3A77 3QU6
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Heterocycle Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Cellular Response To Organic Substance Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Transcription From RNA Polymerase II Promoter RNA Metabolic Process Regulation Of Transcription, DNA-templated Response To Organic Substance Regulation Of Cellular Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Gene Expression Response To Stimulus Positive Regulation Of Gene Expression Protein Sumoylation DNA-templated Transcription, Initiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Cellular Response To Organic Cyclic Compound Positive Regulation Of Transcription, DNA-templated Transforming Growth Factor Beta Receptor Signaling Pathway Response To Stress Macromolecule Biosynthetic Process Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Intracellular Receptor Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Cellular Metabolic Process Response To Transforming Growth Factor Beta Regulation Of Cell Death	Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Innate Immune Response TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Innate Immune Response Toll-like Receptor Signaling Pathway Positive Regulation Of Interferon-beta Production Positive Regulation Of Cytokine Production Regulation Of Cytokine Production Immune Response Regulation Of Innate Immune Response Defense Response Regulation Of Interferon-beta Production Immune Response-regulating Signaling Pathway Viral Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immune System Process Positive Regulation Of Interferon-alpha Production Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Defense Response To Virus Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Immune Response Positive Regulation Of Gene Expression Response To Virus Positive Regulation Of Signal Transduction Regulation Of Immune System Process Regulation Of Gene Expression I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Response To Other Organism Signaling Response To Bacterium Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Biotic Stimulus Cell Communication Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter
Tagcloud ?		acceptor acetyltransferase alignment consensus consequently deacetylase dgcr8 e195a e3 ing ing1 ing1b ing2 ing3 ings isg15 k193 ligase marks mislocalized pdsm phosphomimic preferred reveals s199d stoichiometric sumo sumoylation suppressors	antiviral called cif coactivator composed contain creb cytomegalovirus defense establishes foreskin hcmv immediate interacts interferon interferons intrinsic isg54 latent numerous participate possess responsive shortcut stat stat1 stat2 stimulated tentatively
Tagcloud (Difference) ?		acceptor acetyltransferase alignment consensus consequently deacetylase dgcr8 e195a e3 ing ing1 ing1b ing2 ing3 ings isg15 k193 ligase marks mislocalized pdsm phosphomimic preferred reveals s199d stoichiometric sumo sumoylation suppressors	antiviral called cif coactivator composed contain creb cytomegalovirus defense establishes foreskin hcmv immediate interacts interferon interferons intrinsic isg54 latent numerous participate possess responsive shortcut stat stat1 stat2 stimulated tentatively
Tagcloud (Intersection) ?