PIAS4 and PDE4D

Number of citations of the paper that reports this interaction (PubMedID 20196770)
0

Data Source:
BioGRID (enzymatic study)

		PIAS4	PDE4D
Description		protein inhibitor of activated STAT 4	phosphodiesterase 4D
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Nuclear Matrix PML Body Transferase Complex	Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Voltage-gated Calcium Channel Complex Cilium Membrane Apical Plasma Membrane Nuclear Membrane Calcium Channel Complex
	Molecular Function	DNA Binding Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Transferase Activity SUMO Transferase Activity Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity SUMO Ligase Activity	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Calcium Channel Regulator Activity Protein Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity Enzyme Binding Signaling Receptor Regulator Activity CAMP Binding Beta-2 Adrenergic Receptor Binding Transmembrane Transporter Binding Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity ATPase Binding Scaffold Protein Binding Heterocyclic Compound Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Hair Follicle Development Double-strand Break Repair Regulation Of Transcription By RNA Polymerase II DNA Damage Response Central Nervous System Development Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Wnt Signaling Pathway Protein Sumoylation Positive Regulation Of Protein Sumoylation Vitamin D Metabolic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of MRNA Stability Negative Regulation Of DNA-templated Transcription Limb Epidermis Development MRNA Destabilization Regulation Of Cellular Response To Stress Negative Regulation Of Protein Localization To Chromatin Positive Regulation Of Keratinocyte Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Double-strand Break Repair Via Homologous Recombination	Regulation Of Heart Rate CAMP Catabolic Process Signal Transduction Positive Regulation Of Heart Rate Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-5 Production Negative Regulation Of Heart Contraction T Cell Receptor Signaling Pathway Establishment Of Endothelial Barrier Cellular Response To CAMP Cellular Response To Epinephrine Stimulus Adrenergic Receptor Signaling Pathway Regulation Of Cardiac Muscle Cell Contraction Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of CAMP/PKA Signal Transduction Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Negative Regulation Of Relaxation Of Cardiac Muscle Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel
Pathways		Vitamin D (calciferol) metabolism SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors SUMOylation of ubiquitinylation proteins SUMOylation of transcription cofactors SUMOylation of SUMOylation proteins SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of DNA replication proteins SUMOylation of immune response proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint	DARPP-32 events G alpha (s) signalling events
Drugs			Adenosine phosphate Caffeine Caffeine Dyphylline Iloprost Papaverine Amrinone Roflumilast Piclamilast Rolipram Rolipram 3,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester 2-[3-(2-Hydroxy-1,1-Dihydroxymethyl-Ethylamino)-Propylamino]-2-Hydroxymethyl-Propane-1,3-Diol Zardaverine 1-(4-Aminophenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester (S)-Rolipram Cilomilast (R)-Rolipram 3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester 1-(4-Methoxyphenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester Crisaborole Ibudilast Tetomilast Exisulind (4R)-4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one 3,5-DIMETHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER 3-isobutyl-1-methyl-7H-xanthine 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid Trapidil
Diseases
GWAS		Chronic lymphocytic leukemia ( 28165464) HDL cholesterol levels ( 32203549) Refractive error ( 32231278)	Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) ( 23648065) Amygdala volume ( 31530798) Asthma ( 19426955) Brain morphology (MOSTest) ( 32665545) Breast cancer ( 29059683 23535729) Chronotype ( 30696823) Cognitive function ( 28808816) Cortical surface area (MOSTest) ( 32665545) Esophageal cancer ( 21642993) Esophageal squamous cell carcinoma ( 25129146) Forced expiratory volume in 1 second (occupational environmental exposures interaction) ( 25979521) General cognitive ability ( 29844566) HDL cholesterol levels ( 32203549) Immune response to smallpox vaccine (IL-6) ( 22610502) Intelligence (MTAG) ( 29326435) Mitochondrial DNA levels ( 30326835) Neuroticism ( 17667963) Obesity-related traits ( 23251661) Obsessive-compulsive disorder ( 30456828) Plasma parathyroid hormone levels ( 30134803) Post bronchodilator FEV1/FVC ratio ( 26634245) Response to antipsychotic treatment ( 23241943) Shigella-associated diarrhea ( 33649051) Sleep duration (long sleep) ( 30846698) Sleep-related phenotypes ( 17903308) Subcortical volume (MOSTest) ( 32665545) Thyroid stimulating hormone levels ( 32769997)
Interacting Genes		91 interacting genes: ACTN1 ALDOA AR AREL1 BARD1 BRCA1 BTAF1 CALCOCO2 CEBPD CHD3 CLK1 COIL ESRRA FTH1 GADD45G GATA1 HDAC1 HDAC2 HNF4A HNRNPUL1 HTT IL15RA IMMT IMPDH2 IRF3 IRF7 KNTC1 KPNB1 KRT18 LAMP2 LCE1D LEF1 LRIF1 MAGEH1 MAP1LC3A MDC1 MPRIP NEFL NR4A2 OAZ1 OPTN PARP1 PDE4A PDE4D PDE4DIP PHF11 PHGDH PIAS1 PIAS2 PLAG1 PRKCZ PRPF40A PTN RBBP8 RIF1 RPA2 SATB1 SERBP1 SERPINA5 SETDB1 SH3GL3 SKIL SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 SNAI2 SNIP1 STIP1 SUMO1 SUMO2 SUMO3 TADA3 TCERG1 TICAM1 TOP1 TOP2A TP53 TRIM27 TRIM32 TRIM38 UBE2I UBE2K VHL VIM YY1 ZBTB34 ZHX1 ZNF512B ZW10	28 interacting genes: ABL1 AKAP6 APP ARRB1 ARRB2 COIL CSNK1A1 FBXO7 FYN GOLGA8EP GOLGA8F GRB2 GSK3B HRAS LYN MAGEA6 MAPK1 MDM2 PAFAH1B1 PDE4DIP PIAS4 PIK3R1 PRKACA RACK1 SPTAN1 SRC TRAF1 TRIM23
Entrez ID		51588	5144
HPRD ID		06910	02530
Ensembl ID		ENSG00000105229	ENSG00000113448
Uniprot IDs		B3KMR4 Q8N2W9	A0A140VJR0 A0A1B0GW84 Q08499
PDB IDs			1E9K 1MKD 1OYN 1PTW 1Q9M 1TB7 1TBB 1XOM 1XON 1XOQ 1XOR 1Y2B 1Y2C 1Y2D 1Y2E 1Y2K 1ZKN 2FM0 2FM5 2PW3 2QYN 3G4G 3G4I 3G4K 3G4L 3G58 3IAD 3IAK 3K4S 3SL3 3SL4 3SL5 3SL6 3SL8 3V9B 4OGB 4W1O 4WCU 5K1I 5K32 5LBO 5TKB 5WH5 5WH6 5WQA 6AKR 6BOJ 6F6U 6F8R 6F8T 6F8U 6F8V 6F8W 6F8X 6FDC 6FDI 6FE7 6FEB 6FET 6FT0 6FTA 6FTW 6FW3 6HWO 6IAG 6IBF 6IM6 6IMB 6IMD 6IMI 6IMO 6IMR 6IMT 6IND 6INK 6INM 6KJZ 6KK0 6LRM 6NJH 6NJI 6NJJ 6RCW 6ZBA 7A8Q 7A9V 7AAG 7AB9 7ABD 7ABE 7ABJ 7AY6 7B9H 7CBJ 7CBQ 7F2K 7F2L 7F2M 7W4X 7W4Y 7XAA 7XAB 7XBB 7YQF 7YSX 8K4C 8K4H 8W4Q 8W4R 8WDN 8WDO 8XXS 8YLC 8ZQ1 8ZQ2 8ZQU 8ZQW
Enriched GO Terms of Interacting Partners?		Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Nucleus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process PML Body Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Chromatin Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Transcription Cis-regulatory Region Binding Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Enzyme Binding Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process SMAD Protein Signal Transduction Chromatin Binding Positive Regulation Of Cell Differentiation DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Heteromeric SMAD Protein Complex Positive Regulation Of Macromolecule Metabolic Process Protein Sumoylation Positive Regulation Of RNA Metabolic Process Transcription Regulator Complex Ubiquitin Protein Ligase Binding Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Apoptotic Process Transforming Growth Factor Beta Receptor Signaling Pathway RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Programmed Cell Death Positive Regulation Of Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Positive Regulation Of Developmental Process	Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Ephrin Receptor Binding Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Cell Communication Positive Regulation Of Signaling Enzyme Binding Positive Regulation Of Signal Transduction Regulation Of Biological Quality Ubiquitin Protein Ligase Binding Negative Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Protein Metabolic Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Enzyme-linked Receptor Protein Signaling Pathway Modulation Of Chemical Synaptic Transmission Regulation Of Cell Projection Organization Regulation Of Transport Regulation Of Cellular Localization Perinuclear Region Of Cytoplasm Protein Modification Process Regulation Of Multicellular Organismal Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Apoptotic Signaling Pathway Regulation Of Vesicle-mediated Transport Positive Regulation Of Cell Migration Positive Regulation Of Catabolic Process Positive Regulation Of Cell Motility Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Locomotion Positive Regulation Of Protein Localization Intracellular Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Endocytosis Positive Regulation Of Proteolysis Positive Regulation Of Protein Metabolic Process Positive Regulation Of Establishment Of Protein Localization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Protein Modification Process Proteasomal Protein Catabolic Process Regulation Of Locomotion Regulation Of MAPK Cascade Fc Receptor Mediated Stimulatory Signaling Pathway
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