PIAS4 and IRF7

Number of citations of the paper that reports this interaction (PubMedID 15251447)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		PIAS4	IRF7
Description		protein inhibitor of activated STAT 4	interferon regulatory factor 7
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Nuclear Matrix PML Body Transferase Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Endosome Membrane
	Molecular Function	DNA Binding Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Transferase Activity SUMO Transferase Activity Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity SUMO Ligase Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Hair Follicle Development Double-strand Break Repair Regulation Of Transcription By RNA Polymerase II DNA Damage Response Central Nervous System Development Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Wnt Signaling Pathway Protein Sumoylation Positive Regulation Of Protein Sumoylation Vitamin D Metabolic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of MRNA Stability Negative Regulation Of DNA-templated Transcription Limb Epidermis Development MRNA Destabilization Regulation Of Cellular Response To Stress Negative Regulation Of Protein Localization To Chromatin Positive Regulation Of Keratinocyte Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Double-strand Break Repair Via Homologous Recombination	Negative Regulation Of Transcription By RNA Polymerase II Immune System Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Adaptive Immune Response Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II DNA Damage Response Signal Transduction Response To Virus Regulation Of Gene Expression Immunoglobulin Mediated Immune Response Establishment Of Viral Latency Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Regulation Of MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway MDA-5 Signaling Pathway Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Monocyte Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Immune Response Defense Response To Virus Type I Interferon-mediated Signaling Pathway Positive Regulation Of Type I Interferon-mediated Signaling Pathway Negative Regulation Of Macrophage Apoptotic Process
Pathways		Vitamin D (calciferol) metabolism SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors SUMOylation of ubiquitinylation proteins SUMOylation of transcription cofactors SUMOylation of SUMOylation proteins SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of DNA replication proteins SUMOylation of immune response proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint	DEx/H-box helicases activate type I IFN and inflammatory cytokines production Interferon gamma signaling TICAM1-dependent activation of IRF3/IRF7 Interferon alpha/beta signaling TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) SARS-CoV-2 activates/modulates innate and adaptive immune responses TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
Drugs
Diseases
GWAS		Chronic lymphocytic leukemia ( 28165464) HDL cholesterol levels ( 32203549) Refractive error ( 32231278)	Systemic lupus erythematosus ( 26502338 27399966 28714469) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 31672989)
Interacting Genes		91 interacting genes: ACTN1 ALDOA AR AREL1 BARD1 BRCA1 BTAF1 CALCOCO2 CEBPD CHD3 CLK1 COIL ESRRA FTH1 GADD45G GATA1 HDAC1 HDAC2 HNF4A HNRNPUL1 HTT IL15RA IMMT IMPDH2 IRF3 IRF7 KNTC1 KPNB1 KRT18 LAMP2 LCE1D LEF1 LRIF1 MAGEH1 MAP1LC3A MDC1 MPRIP NEFL NR4A2 OAZ1 OPTN PARP1 PDE4A PDE4D PDE4DIP PHF11 PHGDH PIAS1 PIAS2 PLAG1 PRKCZ PRPF40A PTN RBBP8 RIF1 RPA2 SATB1 SERBP1 SERPINA5 SETDB1 SH3GL3 SKIL SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 SNAI2 SNIP1 STIP1 SUMO1 SUMO2 SUMO3 TADA3 TCERG1 TICAM1 TOP1 TOP2A TP53 TRIM27 TRIM32 TRIM38 UBE2I UBE2K VHL VIM YY1 ZBTB34 ZHX1 ZNF512B ZW10	27 interacting genes: ACADS AIP ARAF CCDC47 CREBBP EP300 GCLM INSR IRAK1 IRF3 KAT2A KAT2B LTN1 MAVS MYD88 PALD1 PIAS4 SOCS1 SOCS3 TBK1 TICAM1 TICAM2 TLK2 TP53 TRAF6 TRIM28 TRMT61B
Entrez ID		51588	3665
HPRD ID		06910	05441
Ensembl ID		ENSG00000105229	ENSG00000185507
Uniprot IDs		B3KMR4 Q8N2W9	B4E1B1 M9RSF4 Q92985
PDB IDs			2O61
Enriched GO Terms of Interacting Partners?		Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Nucleus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process PML Body Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Chromatin Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Transcription Cis-regulatory Region Binding Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Enzyme Binding Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process SMAD Protein Signal Transduction Chromatin Binding Positive Regulation Of Cell Differentiation DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Heteromeric SMAD Protein Complex Positive Regulation Of Macromolecule Metabolic Process Protein Sumoylation Positive Regulation Of RNA Metabolic Process Transcription Regulator Complex Ubiquitin Protein Ligase Binding Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Apoptotic Process Transforming Growth Factor Beta Receptor Signaling Pathway RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Programmed Cell Death Positive Regulation Of Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Positive Regulation Of Developmental Process	Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Toll-like Receptor 4 Signaling Pathway Activation Of Innate Immune Response Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Type I Interferon Production Cell Surface Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Innate Immune Response Regulation Of Type I Interferon Production Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Immune Response-activating Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Cytoplasmic Pattern Recognition Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Innate Immune Response Interferon-mediated Signaling Pathway Positive Regulation Of Defense Response TRIF-dependent Toll-like Receptor Signaling Pathway Cellular Response To Oxygen-containing Compound Peptidyl-lysine Acetylation Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Lipopolysaccharide-mediated Signaling Pathway Protein Modification Process MyD88-independent Toll-like Receptor Signaling Pathway Cellular Response To Lipopolysaccharide Transferase Activity Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Cellular Response To Molecule Of Bacterial Origin Acetyltransferase Activity Type I Interferon-mediated Signaling Pathway Regulation Of Defense Response Canonical NF-kappaB Signal Transduction MRNA Transcription Macromolecule Metabolic Process Transcription Coregulator Activity Positive Regulation Of Immune Response Histone Acetyltransferase Complex Intracellular Receptor Signaling Pathway Protein-lysine-acetyltransferase Activity Positive Regulation Of Cytokine Production Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Endolysosomal Toll-like Receptor Signaling Pathway
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