PIAS4 and PLAG1

Number of citations of the paper that reports this interaction (PMID 15208321)
6

Data Source:
BioGRID (pull down)

		PIAS4	PLAG1
Gene Name		protein inhibitor of activated STAT, 4	pleiomorphic adenoma gene 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Matrix PML Body	Nucleus
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding Ligase Activity SUMO Transferase Activity Ubiquitin Protein Ligase Binding SUMO Ligase Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Wnt Signaling Pathway Protein Sumoylation Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Sumoylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Keratinocyte Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage	Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Gland Morphogenesis Multicellular Organism Growth Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Glial Cell Proliferation Prostate Gland Growth
Pathways
Drugs
Diseases
GWAS			Height ( 19396169 19343178 19893584 18391951 20189936)
Protein-Protein Interactions		75 interactors: ACTN1 ALDOA AR BARD1 BRCA1 BTAF1 CALCOCO2 CEBPD CHD3 CLK1 COIL ESRRA FTH1 GADD45G HDAC1 HDAC2 HNF4A HNRNPUL1 HTT IL15RA IMMT IMPDH2 IRF3 IRF7 KPNB1 KRT18 LAMP2 LEF1 LRIF1 MAGEH1 MAP1LC3A MDC1 MPRIP NEFL NR4A2 OAZ1 OPTN PARP1 PDE4A PDE4D PDE4DIP PHF11 PHGDH PIAS1 PIAS2 PLAG1 PRPF40A PTN RIF1 SATB1 SERBP1 SERPINA5 SETDB1 SH3GL3 SKIL SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 SNIP1 SUMO1 SUMO2 SUMO3 TADA3 TCERG1 TICAM1 TP53 TRIM27 TRIM32 UBE2I UBE2K VIM ZHX1 ZNF512B	5 interactors: KPNA2 PIAS1 PIAS2 PIAS4 SMAD3
Entrez ID		51588	5324
HPRD ID		06910	04321
Ensembl ID			ENSG00000181690
Uniprot IDs		Q8N2W9	Q6DJT9
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Heterocycle Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Cellular Response To Organic Substance Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Transcription From RNA Polymerase II Promoter RNA Metabolic Process Regulation Of Transcription, DNA-templated Response To Organic Substance Regulation Of Cellular Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Gene Expression Response To Stimulus Positive Regulation Of Gene Expression Protein Sumoylation DNA-templated Transcription, Initiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Cellular Response To Organic Cyclic Compound Positive Regulation Of Transcription, DNA-templated Transforming Growth Factor Beta Receptor Signaling Pathway Response To Stress Macromolecule Biosynthetic Process Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Intracellular Receptor Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Cellular Metabolic Process Response To Transforming Growth Factor Beta Regulation Of Cell Death	Protein Sumoylation Positive Regulation Of Protein Sumoylation Regulation Of Protein Sumoylation Peptidyl-lysine Modification Androgen Receptor Signaling Pathway Intracellular Steroid Hormone Receptor Signaling Pathway Protein Modification By Small Protein Conjugation Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transforming Growth Factor Beta3 Production Regulation Of Osteoblast Differentiation Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Keratinocyte Apoptotic Process Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process RNA Biosynthetic Process Signal Transduction Evasion Or Tolerance Of Host Defenses By Virus Peptidyl-amino Acid Modification Positive Regulation Of Cellular Metabolic Process Regulation Of Ossification Positive Regulation Of Apoptotic Signaling Pathway Intracellular Receptor Signaling Pathway Nitrogen Compound Metabolic Process Signaling Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Positive Regulation Of Extracellular Matrix Assembly Regulation Of Signal Transduction Cell Communication Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Extracellular Matrix Assembly Positive Regulation Of Smooth Muscle Cell Differentiation Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Primary MiRNA Processing Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Proteolysis RNA Metabolic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage SMAD Protein Complex Assembly Negative Regulation Of Osteoblast Proliferation Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated
Tagcloud ?		acceptor acetyltransferase alignment consensus consequently deacetylase dgcr8 e195a e3 ing ing1 ing1b ing2 ing3 ings isg15 k193 ligase marks mislocalized pdsm phosphomimic preferred reveals s199d stoichiometric sumo sumoylation suppressors	batch calling classify cooperative driver exome fer filtering fusions h3f3a indels leukemias lmo1 mllt10 nkx2 normalization normalizations obtaining perturbations pipelines ptk2b seq skipping snv snvs ssbp2 stat5b tlx1 tpm3
Tagcloud (Difference) ?		acceptor acetyltransferase alignment consensus consequently deacetylase dgcr8 e195a e3 ing ing1 ing1b ing2 ing3 ings isg15 k193 ligase marks mislocalized pdsm phosphomimic preferred reveals s199d stoichiometric sumo sumoylation suppressors	batch calling classify cooperative driver exome fer filtering fusions h3f3a indels leukemias lmo1 mllt10 nkx2 normalization normalizations obtaining perturbations pipelines ptk2b seq skipping snv snvs ssbp2 stat5b tlx1 tpm3
Tagcloud (Intersection) ?